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Are the determinants of the progression to type 2 diabetes and regression to normoglycemia in the populations with pre-diabetes the same?

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Název: Are the determinants of the progression to type 2 diabetes and regression to normoglycemia in the populations with pre-diabetes the same?
Autoři: Zeinab Alizadeh, Hamid Reza Baradaran, Karim Kohansal, Farzad Hadaegh, Fereidoun Azizi, Davood Khalili
Přispěvatelé: University of Aberdeen.Other Applied Health Sciences, University of Aberdeen.Institute of Applied Health Sciences, University of Aberdeen.Medicine, Medical Sciences & Nutrition
Zdroj: Front Endocrinol (Lausanne)
Frontiers in Endocrinology, Vol 13 (2022)
Informace o vydavateli: Frontiers Media SA, 2022.
Rok vydání: 2022
Témata: Blood Glucose, Supplementary Information, Glucose Intolerance/epidemiology, R Medicine, normoglycemia, Iran, Diseases of the endocrine glands. Clinical endocrinology, Prediabetic State, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, SDG 3 - Good Health and Well-being, pre-diabetes, Glucose Intolerance, Diabetes Mellitus, Cardiometabolic disorders, Humans, Hypoglycemic Agents, Type 2/epidemiology, Prediabetic State/epidemiology, 2. Zero hunger, RC648-665, 16. Peace & justice, Lipids, 3. Good health, Iran/epidemiology, Diabetes Mellitus, Type 2, Disease Progression, regression, Female, type 2 diabetes, progression
Popis: BackgroundWe aimed to determine the predictors of regression to normoglycemia and progression to diabetes among subjects with pre-diabetes in a single model concurrently.MethodsThe present study included 1329 participants aged 20 to 70 years with prediabetes from the population-based cohort of the Tehran Lipid and Glucose Study, with a 10-year follow-up. Glycemic status at follow-up was categorized as regression to normoglycemia: fasting plasma glucose [FPG] of ResultsApproximately 40% of participants returned to normoglycemia (n = 578), and similar percentage of participants progressed to diabetes (n = 518). Based on the multivariable multinomial model, regression to normoglycemia was associated with age (relative risk ratio [RRR] = 0.97; 95% CI, 0.95-0.99), female sex (RRR = 1.72; 95% CI, 1.18-2.50), high education level of ≥12 years (RRR = 2.10; 95% CI, 1.19-3.70), and combined IFG/impaired glucose tolerance (IGT) versus IFG (RRR = 0.45; 95% CI, 0.29-0.70). The risk of progression to diabetes increased with body mass index (RRR = 1.10; 95% CI, 1.05-1.15), waist circumference (RRR = 0.97; 95% CI, 0.96-0.99), positive familial history of diabetes (RRR = 1.62; 95% CI, 1.07-2.45), and combined IFG/IGT versus IFG (RRR = 2.54; 95% CI, 1.71-3.77).ConclusionA small percentage of patients with prediabetes remain in this condition, but the majority go on to develop diabetes or regress to normoglycemia. Both directions had distinct predictors.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
ISSN: 1664-2392
DOI: 10.3389/fendo.2022.1041808
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36277718
https://doaj.org/article/f751f33754b947a68fa613e01674dc3d
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....6f6f024adac8b86f07680c300e81b54d
Databáze: OpenAIRE
Popis
Abstrakt:BackgroundWe aimed to determine the predictors of regression to normoglycemia and progression to diabetes among subjects with pre-diabetes in a single model concurrently.MethodsThe present study included 1329 participants aged 20 to 70 years with prediabetes from the population-based cohort of the Tehran Lipid and Glucose Study, with a 10-year follow-up. Glycemic status at follow-up was categorized as regression to normoglycemia: fasting plasma glucose [FPG] of ResultsApproximately 40% of participants returned to normoglycemia (n = 578), and similar percentage of participants progressed to diabetes (n = 518). Based on the multivariable multinomial model, regression to normoglycemia was associated with age (relative risk ratio [RRR] = 0.97; 95% CI, 0.95-0.99), female sex (RRR = 1.72; 95% CI, 1.18-2.50), high education level of ≥12 years (RRR = 2.10; 95% CI, 1.19-3.70), and combined IFG/impaired glucose tolerance (IGT) versus IFG (RRR = 0.45; 95% CI, 0.29-0.70). The risk of progression to diabetes increased with body mass index (RRR = 1.10; 95% CI, 1.05-1.15), waist circumference (RRR = 0.97; 95% CI, 0.96-0.99), positive familial history of diabetes (RRR = 1.62; 95% CI, 1.07-2.45), and combined IFG/IGT versus IFG (RRR = 2.54; 95% CI, 1.71-3.77).ConclusionA small percentage of patients with prediabetes remain in this condition, but the majority go on to develop diabetes or regress to normoglycemia. Both directions had distinct predictors.
ISSN:16642392
DOI:10.3389/fendo.2022.1041808