Visual search in neurodevelopmental disorders: evidence towards a continuum of impairment
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| Název: | Visual search in neurodevelopmental disorders: evidence towards a continuum of impairment |
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| Autoři: | Christoph Klein, Ludger Tebartz van Elst, André Beauducel, Katarina Müller, Nikolaos Smyrnis, Christian Fleischhaker, Chara Ioannou, Berthold Martin, Monica Biscaldi, Daniela Canu |
| Zdroj: | Eur Child Adolesc Psychiatry |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2021. |
| Rok vydání: | 2021 |
| Témata: | 2. Zero hunger, Adolescent, Autism Spectrum Disorder, 05 social sciences, Original Contribution, Adolescent [MeSH], Attention Deficit Disorder with Hyperactivity/psychology [MeSH], Humans [MeSH], Cognitive Dysfunction [MeSH], Schizophrenia [MeSH], Schizophrenia, Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder/psychology [MeSH], Eye movement, Serial visual search, Cognition [MeSH], Autism Spectrum Disorder (ASD), 03 medical and health sciences, Cognition, 0302 clinical medicine, Attention Deficit Disorder with Hyperactivity, Humans, Cognitive Dysfunction, 0501 psychology and cognitive sciences, 10. No inequality |
| Popis: | Disorders with neurodevelopmental aetiology such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) and Schizophrenia share commonalities at many levels of investigation despite phenotypic differences. Evidence of genetic overlap has led to the concept of a continuum of neurodevelopmental impairment along which these disorders can be positioned in aetiological, pathophysiological and developmental features. This concept requires their simultaneous comparison at different levels, which has not been accomplished so far. Given that cognitive impairments are core to the pathophysiology of these disorders, we provide for the first time differentiated head-to-head comparisons in a complex cognitive function, visual search, decomposing the task with eye movement-based process analyses. N = 103 late-adolescents with schizophrenia, ADHD, ASD and healthy controls took a serial visual search task, while their eye movements were recorded. Patients with schizophrenia presented the greatest level of impairment across different phases of search, followed by patients with ADHD, who shared with patients with schizophrenia elevated intra-subject variability in the pre-search stage. ASD was the least impaired group, but similar to schizophrenia in post-search processes and to schizophrenia and ADHD in pre-search processes and fixation duration while scanning the items. Importantly, the profiles of deviancy from controls were highly correlated between all three clinical groups, in line with the continuum idea. Findings suggest the existence of one common neurodevelopmental continuum of performance for the three disorders, while quantitative differences appear in the level of impairment. Given the relevance of cognitive impairments in these three disorders, we argue in favour of overlapping pathophysiological mechanisms. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | |
| Jazyk: | English |
| ISSN: | 1435-165X 1018-8827 |
| DOI: | 10.1007/s00787-021-01756-z |
| Přístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s00787-021-01756-z.pdf https://pubmed.ncbi.nlm.nih.gov/33751240 https://link.springer.com/content/pdf/10.1007/s00787-021-01756-z.pdf https://link.springer.com/article/10.1007/s00787-021-01756-z https://pubmed.ncbi.nlm.nih.gov/33751240/ https://europepmc.org/article/MED/33751240 https://pergamos.lib.uoa.gr/uoa/dl/object/2982708 https://repository.publisso.de/resource/frl:6449100 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....6eafa8b912f71dde32e9db3f1f445120 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Disorders with neurodevelopmental aetiology such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) and Schizophrenia share commonalities at many levels of investigation despite phenotypic differences. Evidence of genetic overlap has led to the concept of a continuum of neurodevelopmental impairment along which these disorders can be positioned in aetiological, pathophysiological and developmental features. This concept requires their simultaneous comparison at different levels, which has not been accomplished so far. Given that cognitive impairments are core to the pathophysiology of these disorders, we provide for the first time differentiated head-to-head comparisons in a complex cognitive function, visual search, decomposing the task with eye movement-based process analyses. N = 103 late-adolescents with schizophrenia, ADHD, ASD and healthy controls took a serial visual search task, while their eye movements were recorded. Patients with schizophrenia presented the greatest level of impairment across different phases of search, followed by patients with ADHD, who shared with patients with schizophrenia elevated intra-subject variability in the pre-search stage. ASD was the least impaired group, but similar to schizophrenia in post-search processes and to schizophrenia and ADHD in pre-search processes and fixation duration while scanning the items. Importantly, the profiles of deviancy from controls were highly correlated between all three clinical groups, in line with the continuum idea. Findings suggest the existence of one common neurodevelopmental continuum of performance for the three disorders, while quantitative differences appear in the level of impairment. Given the relevance of cognitive impairments in these three disorders, we argue in favour of overlapping pathophysiological mechanisms. |
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| ISSN: | 1435165X 10188827 |
| DOI: | 10.1007/s00787-021-01756-z |