Tumor-infiltrating lymphocytes are associated with poor prognosis in invasive lobular breast carcinoma
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| Název: | Tumor-infiltrating lymphocytes are associated with poor prognosis in invasive lobular breast carcinoma |
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| Autoři: | Anne Tardivon, Anne Vincent-Salomon, Caroline Saint-Martin, Lounes Djerroudi, Matthieu Carton, F Reyal, François-Clément Bidard, André Filipe Vieira, Youlia Kirova, Jean-Christophe Tille, Laëtitia Furhmann |
| Přispěvatelé: | HAL UVSQ, Équipe, Hôpitaux Universitaires de Genève (HUG), Institut Curie Paris, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Universidade do Porto = University of Porto, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Fundo Regional para a Ciência e Tecnologia, FRCT, Funding AFV received support from a Mayent-Rothschild fellowship from Institut Curie, France and IPATIMUP/Fundação para a Ciência e Tecnologia, Portugal. |
| Zdroj: | Modern pathology, Vol. 33, No 11 (2020) pp. 2198-2207 |
| Informace o vydavateli: | Elsevier BV, 2020. |
| Rok vydání: | 2020 |
| Témata: | Receptor, ErbB-2, [SDV]Life Sciences [q-bio], Carcinoma, Lobular / immunology, Breast Neoplasms, ddc:616.07, 616.07, Receptor, ErbB-2 / metabolism, Breast Neoplasms / metabolism, Breast Neoplasms / immunology, Carcinoma, Lobular / mortality, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Lymphocytes, Tumor-Infiltrating / immunology, Humans, Carcinoma, Lobular / metabolism, Retrospective Studies, Breast Neoplasms / mortality, Carcinoma, Lobular / pathology, Age Factors, Middle Aged, Prognosis, Receptors, Estrogen / metabolism, 3. Good health, [SDV] Life Sciences [q-bio], Survival Rate, Carcinoma, Lobular, Receptors, Progesterone / metabolism, Receptors, Estrogen, Breast Neoplasms / pathology, Female, Receptors, Progesterone, Lymphocytes, Tumor-Infiltrating / pathology |
| Popis: | The prognostic impact of tumor-infiltrating lymphocytes (TILs) within invasive lobular carcinoma (ILC) remains to be better characterized. In estrogen receptor (ER)-negative invasive ductal carcinomas of no special type (IDC-NST), TILs are associated with good prognosis. The aim of this study was to examine TILs in ILC, with particular focus on prognostic and clinicopathologic features. A cohort comprising 459 consecutive ILCs diagnosed in a single institution from 2005 to 2008 met the eligibility criteria for this study. The percentage of tumor area occupied by TILs was quantified by two breast pathologists and categorized into three groups: no TILs, ≤5%, >5%. Clinicopathologic features were tested by Fisher's exact tests or Chi2 tests. Overall survival (OS) and invasive disease-free survival (iDFS) were estimated by Kaplan-Meier and Cox proportional hazard statistics. There were 239 TIL-negative cases, 185 cases with ≤5% TILs, and 35 cases with >5% TILs. TILs were associated with younger age, larger tumors, lymph node involvement, poor Nottingham prognostic index, HER2 amplification, multinucleation, and prominent nucleoli (p 5% TILs, respectively, vs. absence of TILs). Prominent nucleoli was the only nuclear feature associated with poor OS (p = 0.05) and iDFS (p = 0.05) in univariate Cox survival analysis. TILs represent a promising new morphologic biomarker associated with poor outcome of ILC, in contrast with that observed in ER-negative IDC-NST. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/s41379-020-0561-9 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/32404955 https://hal.archives-ouvertes.fr/hal-03032297 https://www.nature.com/articles/s41379-020-0561-9.pdf https://www.ncbi.nlm.nih.gov/pubmed/32404955 https://archive-ouverte.unige.ch/unige:155787 https://www.nature.com/articles/s41379-020-0561-9 https://pubmed.ncbi.nlm.nih.gov/32404955/ https://archive-ouverte.unige.ch/unige:155787 |
| Rights: | Elsevier Non-Commercial |
| Přístupové číslo: | edsair.doi.dedup.....6e706a06496cec3a93a064f39656fada |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The prognostic impact of tumor-infiltrating lymphocytes (TILs) within invasive lobular carcinoma (ILC) remains to be better characterized. In estrogen receptor (ER)-negative invasive ductal carcinomas of no special type (IDC-NST), TILs are associated with good prognosis. The aim of this study was to examine TILs in ILC, with particular focus on prognostic and clinicopathologic features. A cohort comprising 459 consecutive ILCs diagnosed in a single institution from 2005 to 2008 met the eligibility criteria for this study. The percentage of tumor area occupied by TILs was quantified by two breast pathologists and categorized into three groups: no TILs, ≤5%, >5%. Clinicopathologic features were tested by Fisher's exact tests or Chi2 tests. Overall survival (OS) and invasive disease-free survival (iDFS) were estimated by Kaplan-Meier and Cox proportional hazard statistics. There were 239 TIL-negative cases, 185 cases with ≤5% TILs, and 35 cases with >5% TILs. TILs were associated with younger age, larger tumors, lymph node involvement, poor Nottingham prognostic index, HER2 amplification, multinucleation, and prominent nucleoli (p 5% TILs, respectively, vs. absence of TILs). Prominent nucleoli was the only nuclear feature associated with poor OS (p = 0.05) and iDFS (p = 0.05) in univariate Cox survival analysis. TILs represent a promising new morphologic biomarker associated with poor outcome of ILC, in contrast with that observed in ER-negative IDC-NST. |
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| ISSN: | 08933952 |
| DOI: | 10.1038/s41379-020-0561-9 |