Chronic vagus nerve stimulation for treatment-resistant depression increases regional cerebral blood flow in the dorsolateral prefrontal cortex
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| Název: | Chronic vagus nerve stimulation for treatment-resistant depression increases regional cerebral blood flow in the dorsolateral prefrontal cortex |
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| Autoři: | Markus Kosel, C. Frick, Holger Brockmann, Thomas E. Schlaepfer, A. Zobel |
| Zdroj: | Psychiatry Research, Vol. 191, No 3 (2011) pp. 153-9 |
| Informace o vydavateli: | Elsevier BV, 2011. |
| Rok vydání: | 2011 |
| Témata: | Adult, Male, Time Factors, Adolescent, Vagus Nerve Stimulation, Cerebrovascular Circulation/physiology, ddc:616.89, Young Adult, 03 medical and health sciences, Technetium Tc 99m Exametazime, 0302 clinical medicine, Humans, Vagus Nerve Stimulation/methods, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon, Brain Mapping, Depression, Depression/physiopathology/radionuclide imaging/therapy, Middle Aged, Tomography, Emission-Computed, Single-Photon/methods, Regional Blood Flow, 616.89, Cerebrovascular Circulation, Female, Technetium Tc 99m Exametazime/diagnostic use |
| Popis: | The purpose of the present study was to assess the effects of vagus nerve stimulation (VNS) therapy on regional cerebral blood flow (rCBF) in depressed patients. Regional cerebral blood flow (rCBF) was assessed by [(99m)Tc]-HMPAO-single photon emission computed tomography (SPECT) before and after 10weeks of VNS in patients participating in an open, uncontrolled European multi-center study investigating efficacy and safety of VNS. Patients suffered from major depression, with a baseline score of≥20 on the 24-item Hamilton Depression Rating Scale (HDRS) and had been unsuccessfully treated with at least two adequately prescribed antidepressant drugs. Data of 15 patients could be analyzed using SPM 2. After 10weeks of VNS (20Hz, 500μs pulse width, stimulation during 30s every 5min at the maximal comfortable level) rCBF was increased in the left dorsolateral/ventrolateral prefrontal cortex (Brodmann areas 46 and 47) and decreased in the right posterior cingulate area, the lingual gyrus and the left insula. Our findings are in line with earlier results which showed that VNS increases rCBF in the left dorsolateral prefrontal cortex. The modulation of the activity in this region could be associated with the antidepressant efficacy of VNS. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2010.11.004 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/21306877 https://core.ac.uk/display/60842817 https://www.sciencedirect.com/science/article/pii/S0925492710003859 https://www.biomed-data.eu/article/chronic-vagus-nerve-stimulation-treatment-resistant-depression-increases-regional-cerebral http://www.sciencedirect.com/science/article/pii/S0925492710003859 https://www.ncbi.nlm.nih.gov/pubmed/21306877 https://archive-ouverte.unige.ch/unige:24046 https://archive-ouverte.unige.ch/unige:24046 https://doi.org/10.1016/j.pscychresns.2010.11.004 https://archive-ouverte.unige.ch/unige:24046 |
| Rights: | Elsevier TDM |
| Přístupové číslo: | edsair.doi.dedup.....6e47ba15bfd0447aec6462fc1e3ce68b |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The purpose of the present study was to assess the effects of vagus nerve stimulation (VNS) therapy on regional cerebral blood flow (rCBF) in depressed patients. Regional cerebral blood flow (rCBF) was assessed by [(99m)Tc]-HMPAO-single photon emission computed tomography (SPECT) before and after 10weeks of VNS in patients participating in an open, uncontrolled European multi-center study investigating efficacy and safety of VNS. Patients suffered from major depression, with a baseline score of≥20 on the 24-item Hamilton Depression Rating Scale (HDRS) and had been unsuccessfully treated with at least two adequately prescribed antidepressant drugs. Data of 15 patients could be analyzed using SPM 2. After 10weeks of VNS (20Hz, 500μs pulse width, stimulation during 30s every 5min at the maximal comfortable level) rCBF was increased in the left dorsolateral/ventrolateral prefrontal cortex (Brodmann areas 46 and 47) and decreased in the right posterior cingulate area, the lingual gyrus and the left insula. Our findings are in line with earlier results which showed that VNS increases rCBF in the left dorsolateral prefrontal cortex. The modulation of the activity in this region could be associated with the antidepressant efficacy of VNS. |
|---|---|
| ISSN: | 09254927 |
| DOI: | 10.1016/j.pscychresns.2010.11.004 |