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The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair

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Názov:	The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
Autori:	Danka Grčević, Marina Sironi, Sonia Valentino, Livija Deban, Hrvoje Cvija, Antonio Inforzato, Nataša Kovačić, Vedran Katavić, Tomislav Kelava, Ivo Kalajzić, Alberto Mantovani, Barbara Bottazzi
Zdroj:	Front Immunol Frontiers in Immunology, Vol 9 (2018) Frontiers in Immunology
Informácie o vydavateľovi:	Frontiers Media SA, 2018.
Rok vydania:	2018
Predmety:	Male, 0301 basic medicine, bone turnover, Bone Remodeling/genetics, Immunology, Fractures, Bone/metabolism, bone healing, fibroblast growth factor 2, inflammation, osteoblast, osteoclast, pentraxin 3, Fractures, Bone, Mice, 03 medical and health sciences, Osteoblasts/physiology, Tibia/surgery, Animals, Humans, Cells, Cultured, Mice, Knockout, Serum Amyloid P-Component/metabolism, Wound Healing, 0303 health sciences, Osteoblasts, Tibia, C-Reactive Protein/metabolism, Cell Differentiation, X-Ray Microtomography, Wound Healing/genetics, RC581-607, Fibroblast Growth Factor 2/metabolism, Mice, Inbred C57BL, Disease Models, Animal, Serum Amyloid P-Component, C-Reactive Protein, Serum Amyloid P-Component/genetics, Female, Fibroblast Growth Factor 2, Bone Remodeling, Immunologic diseases. Allergy, C-Reactive Protein/genetics
Popis:	Pentraxin 3 (PTX3) is an inflammatory mediator acting as a fluid-phase pattern recognition molecule and playing an essential role in innate immunity and matrix remodeling. Inflammatory mediators also contribute to skeletal homeostasis, operating at multiple levels in physiological and pathological conditions. This study was designed to investigate the role of PTX3 in physiological skeletal remodeling and bone healing. Micro-computed tomography (μCT) and bone histomorphometry of distal femur showed that PTX3 gene-targeted female and male mice (ptx3-/- ) had lower trabecular bone volume than their wild-type (ptx3+/+ ) littermates (BV/TV by μCT: 3.50 ± 1.31 vs 6.09 ± 1.17 for females, p
Druh dokumentu:	Article Other literature type
Popis súboru:	application/pdf
ISSN:	1664-3224
DOI:	10.3389/fimmu.2018.00417
Prístupová URL adresa:	https://www.frontiersin.org/articles/10.3389/fimmu.2018.00417/pdf https://pubmed.ncbi.nlm.nih.gov/29556234 https://www.bib.irb.hr/1100742 https://doi.org/10.3389/fimmu.2018.00417 https://doaj.org/article/f48ea8027f78452d9923f6f0c2efd391 https://www.frontiersin.org/articles/10.3389/fimmu.2018.00417/full https://doi.org/10.3389/fimmu.2018.00417 http://europepmc.org/articles/PMC5845433 https://pubmed.ncbi.nlm.nih.gov/29556234/ https://www.frontiersin.org/articles/10.3389/fimmu.2018.00417/full https://core.ac.uk/display/153664310 http://journal.frontiersin.org/article/10.3389/fimmu.2018.00417/full https://www.frontiersin.org/articles/10.3389/fimmu.2018.00417/pdf https://urn.nsk.hr/urn:nbn:hr:105:636402 https://doi.org/10.3389/fimmu.2018.00417
Rights:	CC BY URL: http://rightsstatements.org/vocab/InC/1.0/
Prístupové číslo:	edsair.doi.dedup.....6db1805fd753291da71a03b611a53ab5
Databáza:	OpenAIRE

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Abstrakt:	Pentraxin 3 (PTX3) is an inflammatory mediator acting as a fluid-phase pattern recognition molecule and playing an essential role in innate immunity and matrix remodeling. Inflammatory mediators also contribute to skeletal homeostasis, operating at multiple levels in physiological and pathological conditions. This study was designed to investigate the role of PTX3 in physiological skeletal remodeling and bone healing. Micro-computed tomography (μCT) and bone histomorphometry of distal femur showed that PTX3 gene-targeted female and male mice (ptx3-/- ) had lower trabecular bone volume than their wild-type (ptx3+/+ ) littermates (BV/TV by μCT: 3.50 ± 1.31 vs 6.09 ± 1.17 for females, p
ISSN:	16643224
DOI:	10.3389/fimmu.2018.00417