Electrophysiological effects of intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells
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| Title: | Electrophysiological effects of intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells |
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| Authors: | Katritsis, Demosthenes G, Sotiropoulou, Panagiota, Giazitzoglou, Eleftherios, Karvouni, Evangelia, Papamichail, Michael |
| Source: | EP Europace. 9:167-171 |
| Publisher Information: | Oxford University Press (OUP), 2007. |
| Publication Year: | 2007 |
| Subject Terms: | Adult, Male, Myocardial Infarction, Mesenchymal Stem Cell Transplantation -- adverse effects -- methods, Cardiac -- etiology, Arrhythmias, Mesenchymal Stem Cell Transplantation, Left -- physiology, Transplantation, Autologous, Ventricular Function, Left, 12. Responsible consumption, 03 medical and health sciences, 0302 clinical medicine, Ventricular Function, Humans, Transplantation, Arrhythmias, Cardiac, Sciences bio-médicales et agricoles, Middle Aged, Defibrillators, Implantable, 3. Good health, Treatment Outcome, Implantable, Myocardial Infarction -- pathology -- physiopathology -- therapy, Autologous, Defibrillators, Follow-Up Studies |
| Description: | Autologous stem cell transplantation has been successfully used for repair of infarcted myocardium, but concerns have been raised regarding its pro-arrhythmic potential. This study aimed at using electrophysiological assessment, and the monitoring and data storage capacity of implanted cardioverter defibrillators (ICDs), in order to evaluate the possible proarrhythmic potential of stem cell transplantation.Five patients with a history of previous anteroseptal myocardial infarction and an implanted ICD for ventricular arrhythmias underwent intracoronary transplantation of autologous bone marrow-derived and culture-expanded mesenchymal stem cells in combination with endothelial progenitors.There was evidence of myocardial repair in three patients in whom segmental left ventricular wall motion improvement was detected on stress echocardiography. Before stem cell transplantation, clinical non-sustained ventricular tachycardia and inducible monomorphic ventricular tachycardia, or ventricular flutter at electrophysiology study were demonstrated in all patients. At 16-36 months follow-up, interrogation of the ICD failed to detect sustained or non-sustained ventricular arrhythmia in any patient. At repeat electrophysiology study, sustained ventricular arrhythmia was induced in two patients.Intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells does not appear to be arrhythmogenic in humans. Further studies are needed on this important clinical issue. |
| Document Type: | Article |
| File Description: | No full-text files |
| Language: | English |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/eul184 |
| Access URL: | https://academic.oup.com/europace/article-pdf/9/3/167/1702832/eul184.pdf https://pubmed.ncbi.nlm.nih.gov/17272327 https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/142134/Details http://academic.oup.com/europace/article/9/3/167/616982/Electrophysiological-effects-of-intracoronary http://europepmc.org/abstract/MED/17272327 https://pubmed.ncbi.nlm.nih.gov/17272327/ https://academic.oup.com/europace/article/9/3/167/616982 https://core.ac.uk/display/17344433 |
| Accession Number: | edsair.doi.dedup.....6c0b5c4cebb81a84a088714f6bb6dae0 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Autologous stem cell transplantation has been successfully used for repair of infarcted myocardium, but concerns have been raised regarding its pro-arrhythmic potential. This study aimed at using electrophysiological assessment, and the monitoring and data storage capacity of implanted cardioverter defibrillators (ICDs), in order to evaluate the possible proarrhythmic potential of stem cell transplantation.Five patients with a history of previous anteroseptal myocardial infarction and an implanted ICD for ventricular arrhythmias underwent intracoronary transplantation of autologous bone marrow-derived and culture-expanded mesenchymal stem cells in combination with endothelial progenitors.There was evidence of myocardial repair in three patients in whom segmental left ventricular wall motion improvement was detected on stress echocardiography. Before stem cell transplantation, clinical non-sustained ventricular tachycardia and inducible monomorphic ventricular tachycardia, or ventricular flutter at electrophysiology study were demonstrated in all patients. At 16-36 months follow-up, interrogation of the ICD failed to detect sustained or non-sustained ventricular arrhythmia in any patient. At repeat electrophysiology study, sustained ventricular arrhythmia was induced in two patients.Intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells does not appear to be arrhythmogenic in humans. Further studies are needed on this important clinical issue. |
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| ISSN: | 15322092 10995129 |
| DOI: | 10.1093/europace/eul184 |