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Longitudinal study on 3D ultrasound-based rupture risk assessment of abdominal aortic aneurysms

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Název: Longitudinal study on 3D ultrasound-based rupture risk assessment of abdominal aortic aneurysms
Autoři: Arjet Nievergeld, Judith Fonken, Mirunalini Thirugnanasambandam, Esther Maas, Marc van Sambeek, Richard Lopata
Zdroj: European Heart Journal - Cardiovascular Imaging. 26:741-752
Informace o vydavateli: Oxford University Press (OUP), 2025.
Rok vydání: 2025
Témata: Male, abdominal aortic aneurysms, ultrasound, Aortic Rupture, longitudinal study, Ultrasonography/methods, Abdominal/diagnostic imaging, Middle Aged, peak wall rupture index, Risk Assessment, Aortic Aneurysm, Imaging, Aortic Rupture/diagnostic imaging, Imaging, Three-Dimensional, patient-specific modelling, Three-Dimensional, Humans, Female, Longitudinal Studies, rupture risk prediction, Aortic Aneurysm, Abdominal, Aged, Ultrasonography
Popis: Aims Image-based, patient-specific rupture risk analysis of abdominal aortic aneurysms (AAAs) is promising but it is limited by invasive and costly imaging modalities. Ultrasound (US) offers a safe, more affordable alternative, allowing multiple assessments during follow-up and enabling longitudinal studies on AAA rupture risk. Methods and results This study used time-resolved 3D US to assess AAA rupture risk parameters over time, based on vessel and intraluminal thrombus (ILT) geometry. The locations and magnitude of peak wall rupture index (PWRI), peak wall stress (PWS), and maximum ILT thickness for varying AAA growth rates, and the correlation between PWRI, PWS, and geometric parameters were investigated. This study demonstrated that US-based biomechanical analysis is suitable for assessing rupture potential, providing insights into the evolution through various phases in AAA development. For the fast-growing AAAs, the location of PWRI moved closer to the locations of maximum ILT thickness, whereas the location of PWS moved further away. The newly introduced parameter, i.e. percentage of ILT expected for an aneurysm with a healthy lumen, showed a stronger correlation with PWS and PWRI and was less dependent on AAA size, indicating the potential for further research on ILT's impact on AAA rupture risk. Conclusion This study represents a step towards clinical introduction of US-based AAA rupture risk analysis. Further research and randomized trials are required to directly correlate PWRI with rupture risk. Further improvement of ILT visibility and personalization of the US-based models will be required to achieve clinical acceptance of model-based rupture risk predictions.
Druh dokumentu: Article
Jazyk: English
ISSN: 2047-2412
2047-2404
DOI: 10.1093/ehjci/jeaf030
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39882970
https://research.tue.nl/en/publications/96c70228-83a3-4f4e-8569-cbd61230598b
https://doi.org/10.1093/ehjci/jeaf030
Rights: OUP Standard Publication Reuse
Přístupové číslo: edsair.doi.dedup.....6b4098c004553d45b0a89152fb197802
Databáze: OpenAIRE
Popis
Abstrakt:Aims Image-based, patient-specific rupture risk analysis of abdominal aortic aneurysms (AAAs) is promising but it is limited by invasive and costly imaging modalities. Ultrasound (US) offers a safe, more affordable alternative, allowing multiple assessments during follow-up and enabling longitudinal studies on AAA rupture risk. Methods and results This study used time-resolved 3D US to assess AAA rupture risk parameters over time, based on vessel and intraluminal thrombus (ILT) geometry. The locations and magnitude of peak wall rupture index (PWRI), peak wall stress (PWS), and maximum ILT thickness for varying AAA growth rates, and the correlation between PWRI, PWS, and geometric parameters were investigated. This study demonstrated that US-based biomechanical analysis is suitable for assessing rupture potential, providing insights into the evolution through various phases in AAA development. For the fast-growing AAAs, the location of PWRI moved closer to the locations of maximum ILT thickness, whereas the location of PWS moved further away. The newly introduced parameter, i.e. percentage of ILT expected for an aneurysm with a healthy lumen, showed a stronger correlation with PWS and PWRI and was less dependent on AAA size, indicating the potential for further research on ILT's impact on AAA rupture risk. Conclusion This study represents a step towards clinical introduction of US-based AAA rupture risk analysis. Further research and randomized trials are required to directly correlate PWRI with rupture risk. Further improvement of ILT visibility and personalization of the US-based models will be required to achieve clinical acceptance of model-based rupture risk predictions.
ISSN:20472412
20472404
DOI:10.1093/ehjci/jeaf030