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From body mass index to body composition in female infertility

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Titel: From body mass index to body composition in female infertility
Autoren: Ezgi Darıcı, Francisca Pais, Lynn Leemans, Laurence Strypstein, Herman Tournaye, Michel De Vos, Elisabeth De Waele, Christophe Blockeel
Weitere Verfasser: Centre for Reproductive Medicine - Gynaecology, Physiotherapy, Human Physiology and Anatomy, Pain in Motion, Rehabilitation Research, Clinical sciences, Genetics Reproduction and Development, Vitality Research Group, Intensive Care
Quelle: Reproductive BioMedicine Online. 51:104941
Verlagsinformationen: Elsevier BV, 2025.
Publikationsjahr: 2025
Schlagwörter: adiposity, Body Composition/physiology, Infertility, Female/etiology, Humans, Female, pregnancy, Obesity/complications, Body mass index
Beschreibung: Obesity - a global epidemic that the World Obesity Federation expects will affect one in five women by 2030 - is an important factor influencing reproductive health. Its impact extends beyond subfertility, encompassing menstrual irregularities, oligo-anovulation, early pregnancy loss, and complications during pregnancy and delivery. The interplay between excess adiposity, metabolic health and reproductive function is complex, as adipose tissue secretes several adipokines, such as adiponectin and leptin, targeting reproductive and endocrine tissues. However, investigating the role of obesity on fertility and choosing how to define and quantify obesity remains a major challenge. Traditional reliance on body mass index (BMI) may oversimplify this relationship, as individuals with similar BMI can exhibit differing levels of metabolic health and fertility outcomes depending on their body composition and fat distribution. This narrative review examines the relationship between body composition, adiposity and abnormal body weight in reproductive health outcomes, with a focus on fertility and treatment success in women. The analysis evaluates the impact of body composition on fertility treatments, particularly IVF, and discusses implications for clinical practice. By synthesizing current evidence, this review aims to inform future research and guide the development of personalized clinical strategies in reproductive medicine.
Publikationsart: Article
Sprache: English
ISSN: 1472-6483
DOI: 10.1016/j.rbmo.2025.104941
Zugangs-URL: https://biblio.vub.ac.be/vubir/from-body-mass-index-to-body-composition-in-female-infertility(25baa40a-9ad4-47d9-9686-4bf43d7a9f65).html
Rights: Elsevier TDM
Dokumentencode: edsair.doi.dedup.....6ae959cc54733c4bccc72a6373e0c31d
Datenbank: OpenAIRE
Beschreibung
Abstract:Obesity - a global epidemic that the World Obesity Federation expects will affect one in five women by 2030 - is an important factor influencing reproductive health. Its impact extends beyond subfertility, encompassing menstrual irregularities, oligo-anovulation, early pregnancy loss, and complications during pregnancy and delivery. The interplay between excess adiposity, metabolic health and reproductive function is complex, as adipose tissue secretes several adipokines, such as adiponectin and leptin, targeting reproductive and endocrine tissues. However, investigating the role of obesity on fertility and choosing how to define and quantify obesity remains a major challenge. Traditional reliance on body mass index (BMI) may oversimplify this relationship, as individuals with similar BMI can exhibit differing levels of metabolic health and fertility outcomes depending on their body composition and fat distribution. This narrative review examines the relationship between body composition, adiposity and abnormal body weight in reproductive health outcomes, with a focus on fertility and treatment success in women. The analysis evaluates the impact of body composition on fertility treatments, particularly IVF, and discusses implications for clinical practice. By synthesizing current evidence, this review aims to inform future research and guide the development of personalized clinical strategies in reproductive medicine.
ISSN:14726483
DOI:10.1016/j.rbmo.2025.104941