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Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database

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Title: Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database
Authors: Begoña Campos‐Balea, Javier de Castro Carpeño, Bartomeu Massutí, David Vicente‐Baz, Diego Pérez Parente, Pedro Ruiz‐Gracia, Leonardo Crama, Manuel Cobo Dols
Contributors: [Campos-Balea,B] Oncology, Hospital Universitario Lucus Augusti (HULA), Lugo, Spain. [de Castro Carpeño,J] Oncology, Hospital Universitario La Paz, Madrid, Spain. [Massutí,B] Oncology, Hospital Universitario Alicante (ISABIAL), Alicante, Spain. [Vicente-Baz,D] Oncology, Hospital Universitario Virgen Macarena, Seville, Spain. [Pérez Parente, Ruiz-Gracia,P, Crama,L] Lung Cancer. Medical Affairs Department, Roche Farma S.A, Madrid, Spain. [Cobo Dols,M] Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica. Hospitales Universitarios Regional y Virgen de la Victoria. IBIMA, Málaga, Spain.
Source: Thorac Cancer
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
Thoracic Cancer
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Thoracic Cancer, Vol 11, Iss 11, Pp 3357-3364 (2020)
Publisher Information: Wiley, 2020.
Publication Year: 2020
Subject Terms: non‐small cell lung cancer, Lung adenocarcinoma, Male, Lung Neoplasms, overall survival, Adenocarcinoma of Lung, Adenocarcinoma, Carcinoma de pulmón de células no pequeñas, Metastasis, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, metastasis, 03 medical and health sciences, 0302 clinical medicine, Non-small cell lung cancer, Adenocarcinoma del pulmón, Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma, Humans, Overall survival, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms, Neoplasm Metastasis, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, prognostic factor, Lung, RC254-282, non-small cell lung cancer, Metástasis neoplásica, Aged, Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries::SEER Program, Prognostic factor, Liver Neoplasms, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms, Pronóstico, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Medical Subject Headings::Check Tags::Female, Original Articles, Medical Subject Headings::Anatomy::Respiratory System::Lung, Prognosis, 3. Good health, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged, Female, SEER Program
Description: BackgroundLung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real‐world clinical practice.MethodsPatients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi‐square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS.ResultsA total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P P ConclusionsThe presence of liver metastases was the worst prognostic factor for patients with metastatic lung ADC. This factor should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy.Key pointsSignificant findings of the study Regression analysis identified poor prognostic factors for overall survival. Factors were male sex, age ≥ 65 years, lack of family support and presence of liver, bone and brain metastases. Patients with liver metastasis showed the highest HR (HR = 1.45 95% CI: 1.40–1.50). This study included the highest number of adenocarcinoma patients analyzed so far (N = 46 030). What this study adds The presence of liver metastases should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy.
Document Type: Article
Other literature type
File Description: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document
Language: English
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.13681
Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13681
https://pubmed.ncbi.nlm.nih.gov/32986309
https://hdl.handle.net/20.500.12530/67427
http://hdl.handle.net/10668/3848
http://hdl.handle.net/20.500.12105/17983
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6884
https://doaj.org/article/4bf6361d299944fa992649aabb369d44
https://europepmc.org/article/MED/32986309
https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13681
https://pubmed.ncbi.nlm.nih.gov/32986309/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606019
https://hdl.handle.net/20.500.12105/17983
Rights: CC BY
Accession Number: edsair.doi.dedup.....6a93e514ffb8d138b51a3e8db263986f
Database: OpenAIRE
Description
Abstract:BackgroundLung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real‐world clinical practice.MethodsPatients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi‐square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS.ResultsA total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P P ConclusionsThe presence of liver metastases was the worst prognostic factor for patients with metastatic lung ADC. This factor should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy.Key pointsSignificant findings of the study Regression analysis identified poor prognostic factors for overall survival. Factors were male sex, age ≥ 65 years, lack of family support and presence of liver, bone and brain metastases. Patients with liver metastasis showed the highest HR (HR = 1.45 95% CI: 1.40–1.50). This study included the highest number of adenocarcinoma patients analyzed so far (N = 46 030). What this study adds The presence of liver metastases should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy.
ISSN:17597714
17597706
DOI:10.1111/1759-7714.13681