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Aquaporin 1 and 3 as local vitality markers in mechanical and thermal skin injuries

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Title: Aquaporin 1 and 3 as local vitality markers in mechanical and thermal skin injuries
Authors: Julian Prangenberg, E. Doberentz, A. -L. Witte, B. Madea
Source: Int J Legal Med
Publisher Information: Springer Science and Business Media LLC, 2021.
Publication Year: 2021
Subject Terms: Adult, Aged, 80 and over, Keratinocytes, Male, 0301 basic medicine, 2. Zero hunger, Aquaporin 3, Aquaporin 1, Middle Aged, Female [MeSH], Skin/injuries [MeSH], Immunohistochemistry, Aged, 80 and over [MeSH], Forensics, Wound vitality, Aged [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Immunohistochemistry [MeSH], Original Article, Wounds and Injuries/classification [MeSH], Keratinocytes/metabolism [MeSH], Male [MeSH], Aquaporin 3/metabolism [MeSH], Biomarkers/metabolism [MeSH], Aquaporin 1/metabolism [MeSH], 03 medical and health sciences, 0302 clinical medicine, Humans, Wounds and Injuries, Female, Biomarkers, Aged, Skin
Description: Assessment of the vitality of an injury is one of to the main tasks in daily forensic casework. Aquaporins belong to the family of water channels. They enable the transport of water and of small molecules like glycerol through biological channels. So far, 13 classes of aquaporins are identified in vertebrates. The classical aquaporin channels 1, 2 and 4 are only permeable for water. The aquaporin channels 3, 7, 9 and 10 are also called aquaglycerolporins since they can also transport glycerol. Aquaporin 3 is expressed in epidermal keratinocytes. In the present investigation, the aquaporin 1 and 3 expression in mechanically and thermally damaged skin is investigated by immunohistochemistry. The study collective comprises 30 cases (63.3% male and 36.7% female) with an age range between 19 and 95 years (mean value 54.6 years). The skin injury comprises different kinds of blunt force, sharp force, strangulation marks, thermal injury, gunshot wounds and frost erythema. In all kinds of mechanical and trauma injury, an increased expression of aquaporin 3 in the keratinocytes of the epidermis was found. There is no correlation of the aquaporin 3 expression with age, sex, body mass index, duration of agonal period and postmortem interval. Concerning aquaporin 1, there were no differences between injured and uninjured skin. Aquaporin 3 is independently from the kind of skin injury and appears to be a valuable immunohistochemical parameter of vitality.
Document Type: Article
Other literature type
Language: English
ISSN: 1437-1596
0937-9827
DOI: 10.1007/s00414-021-02588-x
Access URL: https://link.springer.com/content/pdf/10.1007/s00414-021-02588-x.pdf
https://pubmed.ncbi.nlm.nih.gov/33855630
https://link.springer.com/article/10.1007/s00414-021-02588-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354899
https://pubmed.ncbi.nlm.nih.gov/33855630/
https://link.springer.com/content/pdf/10.1007/s00414-021-02588-x.pdf
https://repository.publisso.de/resource/frl:6447160
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Accession Number: edsair.doi.dedup.....6a8dd09acef746d2613df7da8d14f0c4
Database: OpenAIRE
Description
Abstract:Assessment of the vitality of an injury is one of to the main tasks in daily forensic casework. Aquaporins belong to the family of water channels. They enable the transport of water and of small molecules like glycerol through biological channels. So far, 13 classes of aquaporins are identified in vertebrates. The classical aquaporin channels 1, 2 and 4 are only permeable for water. The aquaporin channels 3, 7, 9 and 10 are also called aquaglycerolporins since they can also transport glycerol. Aquaporin 3 is expressed in epidermal keratinocytes. In the present investigation, the aquaporin 1 and 3 expression in mechanically and thermally damaged skin is investigated by immunohistochemistry. The study collective comprises 30 cases (63.3% male and 36.7% female) with an age range between 19 and 95 years (mean value 54.6 years). The skin injury comprises different kinds of blunt force, sharp force, strangulation marks, thermal injury, gunshot wounds and frost erythema. In all kinds of mechanical and trauma injury, an increased expression of aquaporin 3 in the keratinocytes of the epidermis was found. There is no correlation of the aquaporin 3 expression with age, sex, body mass index, duration of agonal period and postmortem interval. Concerning aquaporin 1, there were no differences between injured and uninjured skin. Aquaporin 3 is independently from the kind of skin injury and appears to be a valuable immunohistochemical parameter of vitality.
ISSN:14371596
09379827
DOI:10.1007/s00414-021-02588-x