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Hypocaloric Diet Initiated Post-Ischemia Provides Long-Term Neuroprotection and Promotes Peri-Infarct Brain Remodeling by Regulating Metabolic and Survival-Promoting Proteins

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Title: Hypocaloric Diet Initiated Post-Ischemia Provides Long-Term Neuroprotection and Promotes Peri-Infarct Brain Remodeling by Regulating Metabolic and Survival-Promoting Proteins
Authors: Tayana Silva de Carvalho, Eduardo H. Sanchez-Mendoza, Adriana R. Schultz Moreira, Luiza M. Nascentes Melo, Chen Wang, Maryam Sardari, Nina Hagemann, Thorsten R. Doeppner, Christoph Kleinschnitz, Dirk M. Hermann
Contributors: de Carvalho, Tayana Silva, Sanchez-Mendoza, Eduardo H., Schultz Moreira, Adriana R., Nascentes Melo, Luiza M., Wang, Chen, Sardari, Maryam, Hagemann, Nina, Doeppner, Thorsten R., Kleinschnitz, Christoph, Hermann, Dirk M.
Source: Mol Neurobiol
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: Male, 0301 basic medicine, Time Factors, Diet, Reducing, Medizin, Nerve Tissue Proteins, Article, Antioxidants, Brain Ischemia, Mice, 03 medical and health sciences, 0302 clinical medicine, Sirtuin 1, Brain Ischemia/blood [MeSH], Atrophy [MeSH], Mice, Inbred C57BL [MeSH], Brain Ischemia/metabolism [MeSH], Liver/metabolism [MeSH], Nerve Tissue Proteins/metabolism [MeSH], NAD/metabolism [MeSH], Cerebral Infarction/metabolism [MeSH], Sirtuin 1/metabolism [MeSH], Male [MeSH], Neuroprotection [MeSH], Stroke/blood [MeSH], Capillaries/pathology [MeSH], Antioxidants/metabolism [MeSH], Cerebral Infarction/blood [MeSH], Brain/pathology [MeSH], Sirtuin-1, Stroke/pathology [MeSH], Survival Analysis [MeSH], Animals [MeSH], Brain Ischemia/complications [MeSH], Glutathione Peroxidase/metabolism [MeSH], Time Factors [MeSH], Neurological recovery, Neuroprotection, Cerebral Infarction/pathology [MeSH], Calorie restriction, Brain Ischemia/pathology [MeSH], Diet, Reducing [MeSH], Ischemic stroke, Cerebral Infarction/complications [MeSH], Animals, 10. No inequality, Glutathione Peroxidase, Brain, Cerebral Infarction, NAD, Survival Analysis, Capillaries, Mice, Inbred C57BL, Stroke, Liver, Atrophy
Description: Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How a hypocaloric diet influences stroke recovery when initiated after stroke has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately post-ischemia, mice were randomized to two groups receiving moderately hypocaloric (2286 kcal/kg food) or normocaloric (3518 kcal/kg) diets ad libitum. Animals were sacrificed at 3 or 56 days post-ischemia (dpi). Besides increased low density lipoprotein at 3 days and reduced alanine aminotransferase and increased urea at 56 days, no alterations of plasma markers were found in ischemic mice on hypocaloric diet. Body weight mildly decreased over 56 dpi by 7.4%. Hypocaloric diet reduced infarct volume in the acute stroke phase at 3 dpi and decreased brain atrophy, increased neuronal survival and brain capillary density in peri-infarct striatum and reduced motor coordination impairment in tight rope tests in the post-acute stroke phase over up to 56 dpi. The abundance of brain-derived neurotrophic factor, the NAD-dependent deacetylase and longevity protein sirtuin-1, the anti-oxidant glutathione peroxidase-3, and the ammonium detoxifier glutamine synthetase in the peri-infarct brain tissue was increased by hypocaloric diet. This study shows that a moderately hypocaloric diet that is initiated after stroke confers long-term neuroprotection and promotes peri-infarct brain remodeling.
Document Type: Article
Other literature type
Language: English
ISSN: 1559-1182
0893-7648
DOI: 10.1007/s12035-020-02207-7
Access URL: https://link.springer.com/content/pdf/10.1007/s12035-020-02207-7.pdf
https://pubmed.ncbi.nlm.nih.gov/33200399
https://link.springer.com/content/pdf/10.1007/s12035-020-02207-7.pdf
https://europepmc.org/article/MED/33200399
https://link.springer.com/article/10.1007/s12035-020-02207-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932971
https://resolver.sub.uni-goettingen.de/purl?gro-2/83253
https://repository.publisso.de/resource/frl:6471736
Rights: CC BY
Accession Number: edsair.doi.dedup.....6a36b5164d3e9fedd9ce7b460a2d52a7
Database: OpenAIRE
Description
Abstract:Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How a hypocaloric diet influences stroke recovery when initiated after stroke has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately post-ischemia, mice were randomized to two groups receiving moderately hypocaloric (2286 kcal/kg food) or normocaloric (3518 kcal/kg) diets ad libitum. Animals were sacrificed at 3 or 56 days post-ischemia (dpi). Besides increased low density lipoprotein at 3 days and reduced alanine aminotransferase and increased urea at 56 days, no alterations of plasma markers were found in ischemic mice on hypocaloric diet. Body weight mildly decreased over 56 dpi by 7.4%. Hypocaloric diet reduced infarct volume in the acute stroke phase at 3 dpi and decreased brain atrophy, increased neuronal survival and brain capillary density in peri-infarct striatum and reduced motor coordination impairment in tight rope tests in the post-acute stroke phase over up to 56 dpi. The abundance of brain-derived neurotrophic factor, the NAD-dependent deacetylase and longevity protein sirtuin-1, the anti-oxidant glutathione peroxidase-3, and the ammonium detoxifier glutamine synthetase in the peri-infarct brain tissue was increased by hypocaloric diet. This study shows that a moderately hypocaloric diet that is initiated after stroke confers long-term neuroprotection and promotes peri-infarct brain remodeling.
ISSN:15591182
08937648
DOI:10.1007/s12035-020-02207-7