View in EDS

Concentration of soluble urokinase plasminogen activator receptor (suPAR) in the pre-ovulatory follicular fluid is associated with development of ovarian hyperstimulation syndrome during ovarian stimulation

Saved in:
Bibliographic Details
Title: Concentration of soluble urokinase plasminogen activator receptor (suPAR) in the pre-ovulatory follicular fluid is associated with development of ovarian hyperstimulation syndrome during ovarian stimulation
Authors: Grynnerup, A. G., Toftager, M., Zedeler, A, Bogstad, J W, Prætorius, L, Grøndahl, M. L., Yding Andersen, C, Sørensen, S., Pinborg, A., Løssl, K.
Source: Journal of Assisted Reproduction and Genetics. 35:2187-2193
Publisher Information: Springer Science and Business Media LLC, 2018.
Publication Year: 2018
Subject Terms: Adult, Ovulation, Ovulation/genetics, Urokinase Plasminogen Activator/genetics, Fertilization in Vitro, Follicular Fluid, Receptors, Urokinase Plasminogen Activator, 3. Good health, Ovarian Hyperstimulation Syndrome/enzymology, Ovarian Hyperstimulation Syndrome, 03 medical and health sciences, 0302 clinical medicine, Ovulation Induction, Solubility, Receptors, Oocytes, Ovulation Induction/adverse effects, Humans, Female, Oocytes/enzymology, Follicular Fluid/enzymology
Description: Investigating whether pre-ovulatory follicular fluid (FF) levels of selected proteins differ between women who do or do not develop severe ovarian hyperstimulation syndrome (OHSS) and evaluate whether they potentially could guide a "freeze-all" strategy.FF was collected during a randomized controlled trial comparing OHSS in antagonist versus agonist protocol including 1050 women in their first assisted reproductive technology (ART) cycle during year 2009-2013. The present sub-study is a matched case-control study comparing FF levels of soluble urokinase plasminogen activator receptor (suPAR), C-reactive protein, placental growth factor, vascular endothelial growth factor, and angiopoietins 1 and 2 in OHSS cases (n = 25, severe OHSS, and ≥ 15 oocytes), high-risk controls (n = 25, no OHSS, and ≥ 15 oocytes), and low-risk controls (n = 25, no OHSS, and 5-8 oocytes).FF level of suPAR differed significantly between the three groups (p = 0.018) with mean (SD) levels of 2.3 (0.4) μg/L, 2.6 (0.8) μg/L, and 2.8 (0.6) μg/L in OHSS cases, high-risk controls, and low-risk controls, respectively. Receiver operating characteristic curve analysis demonstrated that suPAR levels could predict severe OHSS (AUC 0.678; 95% CI 0.553-0.803) with a sensitivity of 64% and a specificity of 66%. None of the other investigated proteins differed between the three groups or between OHSS cases and combined controls.The pre-ovulatory FF level of suPAR was significantly lower in women developing severe OHSS, indicating that the plasminogen activator system could be involved in the pathophysiology of OHSS. However, suPAR did not provide a satisfying predictive value for the prediction of OHSS.
Document Type: Article
Language: English
ISSN: 1573-7330
1058-0468
DOI: 10.1007/s10815-018-1314-2
Access URL: https://europepmc.org/articles/pmc6289922?pdf=render
https://pubmed.ncbi.nlm.nih.gov/30232642
https://europepmc.org/article/MED/30232642
https://link.springer.com/content/pdf/10.1007%2Fs10815-018-1314-2.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289922
https://link.springer.com/article/10.1007/s10815-018-1314-2
https://pubmed.ncbi.nlm.nih.gov/30232642/
https://www.ncbi.nlm.nih.gov/pubmed/30232642
Rights: Springer TDM
Accession Number: edsair.doi.dedup.....69d72244b97c1e7282a39d37a186f803
Database: OpenAIRE
Description
Abstract:Investigating whether pre-ovulatory follicular fluid (FF) levels of selected proteins differ between women who do or do not develop severe ovarian hyperstimulation syndrome (OHSS) and evaluate whether they potentially could guide a "freeze-all" strategy.FF was collected during a randomized controlled trial comparing OHSS in antagonist versus agonist protocol including 1050 women in their first assisted reproductive technology (ART) cycle during year 2009-2013. The present sub-study is a matched case-control study comparing FF levels of soluble urokinase plasminogen activator receptor (suPAR), C-reactive protein, placental growth factor, vascular endothelial growth factor, and angiopoietins 1 and 2 in OHSS cases (n = 25, severe OHSS, and ≥ 15 oocytes), high-risk controls (n = 25, no OHSS, and ≥ 15 oocytes), and low-risk controls (n = 25, no OHSS, and 5-8 oocytes).FF level of suPAR differed significantly between the three groups (p = 0.018) with mean (SD) levels of 2.3 (0.4) μg/L, 2.6 (0.8) μg/L, and 2.8 (0.6) μg/L in OHSS cases, high-risk controls, and low-risk controls, respectively. Receiver operating characteristic curve analysis demonstrated that suPAR levels could predict severe OHSS (AUC 0.678; 95% CI 0.553-0.803) with a sensitivity of 64% and a specificity of 66%. None of the other investigated proteins differed between the three groups or between OHSS cases and combined controls.The pre-ovulatory FF level of suPAR was significantly lower in women developing severe OHSS, indicating that the plasminogen activator system could be involved in the pathophysiology of OHSS. However, suPAR did not provide a satisfying predictive value for the prediction of OHSS.
ISSN:15737330
10580468
DOI:10.1007/s10815-018-1314-2