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Performance of Diabetes and Kidney Disease Screening Scores in Contemporary United States and Korean Populations

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Titel: Performance of Diabetes and Kidney Disease Screening Scores in Contemporary United States and Korean Populations
Autoren: Liela Meng, Keun-Sang Kwon, Dae Jung Kim, Yong-ho Lee, Jeehyoung Kim, Abhijit V. Kshirsagar, Heejung Bang
Weitere Verfasser: Liela Meng, Keun-Sang Kwon, Dae Jung Kim, Yong-Ho Lee, Jeehyoung Kim, Abhijit V Kshirsagar, Heejung Bang, Lee, Yong Ho
Quelle: Diabetes Metab J
Diabetes & Metabolism Journal, Vol 46, Iss 2, Pp 273-285 (2022)
Diabetes & Metabolism Journal, vol 46, iss 2
Verlagsinformationen: Korean Diabetes Association, 2022.
Publikationsjahr: 2022
Schlagwörter: Kidney Disease, Type 2* / epidemiology, Diseases of the endocrine glands. Clinical endocrinology, Prediabetic State, 03 medical and health sciences, Diabetes mellitus, prediabetic state, 0302 clinical medicine, Health Sciences, Republic of Korea, Diabetes Mellitus, risk factors, Humans, Prediabetic State* / epidemiology, Renal Insufficiency, Chronic, Renal insufficiency, renal insufficiency, chronic, Renal Insufficiency, Chronic, Republic of Korea / epidemiology, United States / epidemiology, Prevention, Diabetes, Chronic* / epidemiology, Middle Aged, self-assessment, RC648-665, Nutrition Surveys, United States, 3. Good health, chronic, Good Health and Well Being, type 2, Risk factors, Self-assessment, diabetes mellitus, type 2, Diabetes Mellitus, Type 2, Prediabetic state, Chronic* / diagnosis, Original Article, Type 2* / diagnosis, Public Health, Prediabetic State* / diagnosis, Type 2
Beschreibung: Background: Risk assessment tools have been actively studied, and they summarize key predictors with relative weights/importance for a disease. Currently, standardized screening scores for type 2 diabetes mellitus (DM) and chronic kidney disease (CKD)—two key global health problems—are available in United States and Korea. We aimed to compare and evaluate screening scores for DM (or combined with prediabetes) and CKD, and assess the risk in contemporary United States and Korean populations.Methods: Four (2×2) models were evaluated in the United States-National Health and Nutrition Examination Survey (NHANES 2015–2018) and Korea-NHANES (2016–2018)—8,928 and 16,209 adults. Weighted statistics were used to describe population characteristics. We used logistic regression for predictors in the models to assess associations with study outcomes (undiagnosed DM and CKD) and diagnostic measures for temporal and cross-validation.Results: Korean adult population (mean age 47.5 years) appeared to be healthier than United States counterpart, in terms of DM and CKD risks and associated factors, with exceptions of undiagnosed DM, prediabetes and prehypertension. Models performed well in own country and external populations regarding predictor-outcome association and discrimination. Risk tests (high vs. low) showed area under the curve >0.75, sensitivity >84%, specificity >45%, positive predictive value >8%, and negative predictive value >99%. Discrimination was better for DM, compared to the combined outcome of DM and prediabetes, and excellent for CKD due to age.Conclusion: Four easy-to-use screening scores for DM and CKD are well-validated in contemporary United States and Korean populations. Prevention of DM and CKD may serve as first-step in public health, with these self-assessment tools as basic tools to help health education and disparity.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 2233-6087
2233-6079
DOI: 10.4093/dmj.2021.0054
Zugangs-URL: https://www.e-dmj.org/upload/pdf/dmj-2021-0054.pdf
https://pubmed.ncbi.nlm.nih.gov/34503311
https://doaj.org/article/520dd3987fa14822bb67f60bd6832ddb
https://pubmed.ncbi.nlm.nih.gov/34503311/
http://e-dmj.org/journal/view.php?doi=10.4093/dmj.2021.0054
https://escholarship.org/uc/item/29068947
https://escholarship.org/content/qt29068947/qt29068947.pdf
Rights: CC BY NC
CC BY NC ND
Dokumentencode: edsair.doi.dedup.....68eec38b74714a52e805ebf69afb48f1
Datenbank: OpenAIRE
Beschreibung
Abstract:Background: Risk assessment tools have been actively studied, and they summarize key predictors with relative weights/importance for a disease. Currently, standardized screening scores for type 2 diabetes mellitus (DM) and chronic kidney disease (CKD)—two key global health problems—are available in United States and Korea. We aimed to compare and evaluate screening scores for DM (or combined with prediabetes) and CKD, and assess the risk in contemporary United States and Korean populations.Methods: Four (2×2) models were evaluated in the United States-National Health and Nutrition Examination Survey (NHANES 2015–2018) and Korea-NHANES (2016–2018)—8,928 and 16,209 adults. Weighted statistics were used to describe population characteristics. We used logistic regression for predictors in the models to assess associations with study outcomes (undiagnosed DM and CKD) and diagnostic measures for temporal and cross-validation.Results: Korean adult population (mean age 47.5 years) appeared to be healthier than United States counterpart, in terms of DM and CKD risks and associated factors, with exceptions of undiagnosed DM, prediabetes and prehypertension. Models performed well in own country and external populations regarding predictor-outcome association and discrimination. Risk tests (high vs. low) showed area under the curve >0.75, sensitivity >84%, specificity >45%, positive predictive value >8%, and negative predictive value >99%. Discrimination was better for DM, compared to the combined outcome of DM and prediabetes, and excellent for CKD due to age.Conclusion: Four easy-to-use screening scores for DM and CKD are well-validated in contemporary United States and Korean populations. Prevention of DM and CKD may serve as first-step in public health, with these self-assessment tools as basic tools to help health education and disparity.
ISSN:22336087
22336079
DOI:10.4093/dmj.2021.0054