Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens
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| Názov: | Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens |
|---|---|
| Autori: | George F. Mayhew, Bart Bryant, Sang Woon Shin, Kristin Michel, Janet Hemingway, Lyric C. Bartholomay, Vladimir A. Kokoza, Sinéad B. Chapman, Patricia Pignatelli, Corey L. Campbell, S. H. P. Parakrama Karunaratne, Peter W. Atkinson, Suchismita Das, Karyn Megy, Rollie J. Clem, Stephen Higgs, Yuemei Dong, Alexander S. Raikhel, Sara M. Erickson, Bruce W. Birren, Bruce M. Christensen, Evgeny M. Zdobnov, Chinnappa D. Kodira, George Dimopoulos, Marc A. T. Muskavitch, Jose Luis Ramirez, Dana L. Vanlandingham, Hilary Ranson, Zhen Zou, Robert M. Waterhouse, George K. Christophides, Peter Arensburger, Kanwal S. Alvarez |
| Prispievatelia: | Entomology |
| Zdroj: | Science (New York N.Y.) |
| Informácie o vydavateľovi: | American Association for the Advancement of Science (AAAS), 2010. |
| Rok vydania: | 2010 |
| Predmety: | 576.5, 0301 basic medicine, Transcription, Genetic, Host-Pathogen Interactions, Infectious Disease, Genes, Insect, Medical Biochemistry, Immunity, Innate/*genetics, 03 medical and health sciences, Aedes, Aedes/genetics/immunology/microbiology/parasitology, Anopheles, 11. Sustainability, Animals, Anopheles gambiae/genetics/metabolism/microbiology/parasitology, Ecosystem, Filarioidea, Phylogeny, Oligonucleotide Array Sequence Analysis, 0303 health sciences, Bacteria, Culex/*genetics/*immunology/microbiology/parasitology, West Nile virus/immunology/pathogenicity/physiology, Gene Expression Profiling, Bacteria/immunology/pathogenicity, Biological Evolution, Immunity, Innate, Insect Vectors, 3. Good health, Culex, Gene Expression Regulation, Virus Diseases, Filarioidea/immunology/pathogenicity/physiology, RNA Interference, Entomology, Arboviruses/immunology/pathogenicity/physiology, Insect Vectors/*genetics/*immunology/microbiology/parasitology, West Nile virus, Arboviruses |
| Popis: | Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major international effort, Arensburger et al. (p. 86 ) uncovered divergences in the C. quinquefasciatus genome compared with the representatives of the other two genera Aedes aegypti and Anopheles gambiae . The main difference noted is the expansion of numbers of genes, particularly for immunity, oxidoreductive functions, and digestive enzymes, which may reflect specific aspects of the Culex life cycle. Bartholomay et al. (p. 88 ) explored infection-response genes in Culex in more depth and uncovered 500 immune response-related genes, similar to the numbers seen in Aedes , but fewer than seen in Anopheles or the fruit fly Drosophila melanogaster . The higher numbers of genes were attributed partly to expansions in those encoding serpins, C-type lectins, and fibrinogen-related proteins, consistent with greater immune surveillance and associated signaling needed to monitor the dangers of breeding in polluted, urbanized environments. Transcriptome analysis confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex . The worm and virus pathogens that the mosquitoes transmit naturally provoked little immune activation, however, suggesting that tolerance has evolved to any damage caused by replication of the pathogens in the insects. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1193162 |
| Prístupová URL adresa: | https://europepmc.org/articles/pmc3104938?pdf=render https://pubmed.ncbi.nlm.nih.gov/20929811 https://jhu.pure.elsevier.com/en/publications/pathogenomics-of-culex-quinquefasciatus-and-meta-analysis-of-infe-4 https://www.cabdirect.org/cabdirect/abstract/20103313436 http://science.sciencemag.org/content/330/6000/88.abstract https://augusta.pure.elsevier.com/en/publications/pathogenomics-of-culex-quinquefasciatus-and-meta-analysis-of-infe https://core.ac.uk/display/29015122 https://science.sciencemag.org/content/sci/330/6000/88.full.pdf |
| Prístupové číslo: | edsair.doi.dedup.....68b28d09964d64bca2833469fd0166a5 |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major international effort, Arensburger et al. (p. 86 ) uncovered divergences in the C. quinquefasciatus genome compared with the representatives of the other two genera Aedes aegypti and Anopheles gambiae . The main difference noted is the expansion of numbers of genes, particularly for immunity, oxidoreductive functions, and digestive enzymes, which may reflect specific aspects of the Culex life cycle. Bartholomay et al. (p. 88 ) explored infection-response genes in Culex in more depth and uncovered 500 immune response-related genes, similar to the numbers seen in Aedes , but fewer than seen in Anopheles or the fruit fly Drosophila melanogaster . The higher numbers of genes were attributed partly to expansions in those encoding serpins, C-type lectins, and fibrinogen-related proteins, consistent with greater immune surveillance and associated signaling needed to monitor the dangers of breeding in polluted, urbanized environments. Transcriptome analysis confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex . The worm and virus pathogens that the mosquitoes transmit naturally provoked little immune activation, however, suggesting that tolerance has evolved to any damage caused by replication of the pathogens in the insects. |
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| ISSN: | 10959203 00368075 |
| DOI: | 10.1126/science.1193162 |