Sealing effectiveness of a novel NHS-POx based patch: experiments in a dynamic ex vivo porcine lung
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| Title: | Sealing effectiveness of a novel NHS-POx based patch: experiments in a dynamic ex vivo porcine lung |
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| Authors: | Hermans, B.P., Li, W.W.L., Roozen, E.A., Dort, D.I.M. van, Evers, Jort, Heijden, E. van der, Heide, S.M. van der, Goor, H. van, Verhagen, A.F.T.M. |
| Source: | J Thorac Dis Journal of Thoracic Disease, 15, 7, pp. 3580-3592 |
| Publisher Information: | AME Publishing Company, 2023. |
| Publication Year: | 2023 |
| Subject Terms: | All institutes and research themes of the Radboud University Medical Center, Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences, Original Article, Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences, Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences |
| Description: | Sealants are used to prevent prolonged pulmonary air leakage (PAL) after lung resections (incidence 5.6-30%). However, clinical evidence to support sealant use is insufficient, with an unmet need for a more effective product. We compared a novel gelatin patch impregnated with functionalized polyoxazolines (NHS-POx) (GATT-Patch) to commercially available sealant products.GATT-Patch Single/Double layers were compared to Progel®, Coseal®, Hemopatch® and TachoSil® in an ex vivo porcine lung model (first experiment). Based on these results, a second head-to-head comparison between GATT-Patch Single and Hemopatch® was performed. Air leakage (AL) was assessed in three settings using increasing ventilatory pressures (max =70 cmH2O): (I) baseline, (II) with 25 mm × 25 mm superficial pleural defect, and (III) after sealant application. Lungs floating on saline (37 ℃) were video recorded for visual AL assessment. Pressure and tidal volumes were collected from the ventilator, and bursting pressure (BP), AL and AL-reduction were determined.Per sealant 10 measurements were performed (both experiments). In the first experiment, BP was superior for GATT-Patch Double (60±24 cmH2O) compared to TachoSil® (30±11 cmH2O, P |
| Document Type: | Article Other literature type |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd-22-1821 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/37559645 https://repository.ubn.ru.nl//bitstream/handle/2066/296053/296053.pdf https://repository.ubn.ru.nl/handle/2066/296053 |
| Rights: | CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....68a2bcebd0f10e2fb2797f94c52baf58 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Sealants are used to prevent prolonged pulmonary air leakage (PAL) after lung resections (incidence 5.6-30%). However, clinical evidence to support sealant use is insufficient, with an unmet need for a more effective product. We compared a novel gelatin patch impregnated with functionalized polyoxazolines (NHS-POx) (GATT-Patch) to commercially available sealant products.GATT-Patch Single/Double layers were compared to Progel®, Coseal®, Hemopatch® and TachoSil® in an ex vivo porcine lung model (first experiment). Based on these results, a second head-to-head comparison between GATT-Patch Single and Hemopatch® was performed. Air leakage (AL) was assessed in three settings using increasing ventilatory pressures (max =70 cmH2O): (I) baseline, (II) with 25 mm × 25 mm superficial pleural defect, and (III) after sealant application. Lungs floating on saline (37 ℃) were video recorded for visual AL assessment. Pressure and tidal volumes were collected from the ventilator, and bursting pressure (BP), AL and AL-reduction were determined.Per sealant 10 measurements were performed (both experiments). In the first experiment, BP was superior for GATT-Patch Double (60±24 cmH2O) compared to TachoSil® (30±11 cmH2O, P |
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| ISSN: | 20776624 20721439 |
| DOI: | 10.21037/jtd-22-1821 |