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Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children

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Title: Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children
Authors: Tülay Becerir, Selcuk Yüksel, Havva Evrengül, Ahmet Ergin, Yaşar Enli
Source: International Urology and Nephrology. 51:571-577
Publisher Information: Springer Science and Business Media LLC, 2019.
Publication Year: 2019
Subject Terms: Male, 0301 basic medicine, clinical evaluation, acute pyelonephritis, Pentraxin 3, preschool child, kidney parenchyma, 0302 clinical medicine, pentraxin 3, Child, Children, acute disease, child, C reactive protein, Pyelonephritis, adult, Vesicoureteral reflux, creatinine, correlational study, biological marker, kidney scar, medical history, urine, 3. Good health, Serum Amyloid P-Component, female, C-Reactive Protein, Child, Preschool, Creatinine, Acute Disease, pyelonephritis, Female, Adolescent, Renal scar, urinary excretion, complication, protein urine level, scar, Article, Cicatrix, 03 medical and health sciences, male, Biomarkers/blood/urine, C-Reactive Protein/metabolism/*urine, Case-Control Studies, Cicatrix/etiology/*urine, Creatinine/urine, Humans, Infant, Pyelonephritis/*complications, Serum Amyloid P-Component/metabolism/*urine, Vesico-Ureteral Reflux/complications/*urine, blood, serum amyloid P, human, Preschool, Vesico-Ureteral Reflux, disease association, vesicoureteral reflux, case control study, infant, major clinical study, adolescent, metabolism, Biomarkers
Description: Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR).The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4).We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min-max 0.0022-12.3668) vs. 2.2 pg/ml (min-max 0.0022-18.5868) and uPTX3/creatinine, 10.5 pg/mg (min-max 0.0035-51.1) vs. 5.8 pg/mg (min-max 0.0004-78.7), p
Document Type: Article
Language: English
ISSN: 1573-2584
0301-1623
DOI: 10.1007/s11255-019-02102-8
Access URL: https://pubmed.ncbi.nlm.nih.gov/30796728
https://link.springer.com/article/10.1007/s11255-019-02102-8
https://europepmc.org/article/MED/30796728
https://www.ncbi.nlm.nih.gov/pubmed/30796728
https://pubmed.ncbi.nlm.nih.gov/30796728/
https://avesis.comu.edu.tr/publication/details/86546e57-02e7-459d-9e81-a0c1106fee93/oai
Rights: Springer TDM
Accession Number: edsair.doi.dedup.....67f33e773892298d5cda86c206db48dc
Database: OpenAIRE
Description
Abstract:Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR).The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4).We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min-max 0.0022-12.3668) vs. 2.2 pg/ml (min-max 0.0022-18.5868) and uPTX3/creatinine, 10.5 pg/mg (min-max 0.0035-51.1) vs. 5.8 pg/mg (min-max 0.0004-78.7), p
ISSN:15732584
03011623
DOI:10.1007/s11255-019-02102-8