An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers
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| Titel: | An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers |
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| Autoren: | Stephanie Marciniak, Christina M. Bergey, Ana Maria Silva, Agata Hałuszko, Mirosław Furmanek, Barbara Veselka, Petr Velemínský, Giuseppe Vercellotti, Joachim Wahl, Gunita Zariņa, Cristina Longhi, Jan Kolář, Rafael Garrido-Pena, Raúl Flores-Fernández, Ana M. Herrero-Corral, Angela Simalcsik, Werner Müller, Alison Sheridan, Žydrūnė Miliauskienė, Rimantas Jankauskas, Vyacheslav Moiseyev, Kitti Köhler, Ágnes Király, Beatriz Gamarra, Olivia Cheronet, Vajk Szeverényi, Viktória Kiss, Tamás Szeniczey, Krisztián Kiss, Zsuzsanna K. Zoffmann, Judit Koós, Magdolna Hellebrandt, Robert M. Maier, László Domboróczki, Cristian Virag, Mario Novak, David Reich, Tamás Hajdu, Noreen von Cramon-Taubadel, Ron Pinhasi, George H. Perry |
| Weitere Verfasser: | Repositório da Universidade de Lisboa, Archaeology, Environmental changes & Geo-Chemistry, History, Archeology, Arts, Philosophy and Ethics |
| Quelle: | Proc Natl Acad Sci U S A Proceedings of the National Academy of Sciences of the United States of America., Washington : National Academy of Sciences, 2022, vol. 119, no. 15, art. no. e2106743119, p. [1-12]. |
| Verlagsinformationen: | Proceedings of the National Academy of Sciences, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | 0301 basic medicine, History, REGRESSION EQUATIONS, WHOLE-GENOME ASSOCIATION, HISTORY, Skeleton/anatomy & histology, POROTIC HYPEROSTOSIS, Child, History, Ancient, 2. Zero hunger, 0303 health sciences, Farmers, stature variation, Body Height/genetics, Agriculture transition, health, Agriculture, Genomics, Biological Sciences, 106018 Humanbiologie, Europe, Health, SDG 3 – Gesundheit und Wohlergehen, Agriculture/history, CRIBRA-ORBITALIA, Adult, Paleopathology, agriculture transition, Ancient, PREHISTORIC POPULATIONS, Health/history, 03 medical and health sciences, AGE, SDG 3 - Good Health and Well-being, Farmers/history, Humans, DNA, Ancient, paleogenomics, stature variation, agriculture transition, health, Skeleton, AGRICULTURAL TRANSITION, 106018 Human biology, Genetic Variation, DNA, Body Height, paleogenomics, Paleogenomics, ORIGINS, PATTERNS, Stature variation |
| Beschreibung: | SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological–genetic model has exciting potential for studies of past human health and expansion into various other contexts. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.2106743119 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/35389750 https://www.pnas.org/doi/10.1073/pnas.2106743119 https://doi.org/10.1073/pnas.2106743119 https://hdl.handle.net/10451/56891 http://hdl.handle.net/10831/114417 https://biblio.vub.ac.be/vubir/an-integrative-skeletal-and-paleogenomic-analysis-of-stature-variation-suggests-relatively-reduced-health-for-early-european-farmers(8bbd871f-6ebd-476a-bd99-21118a54ff53).html https://repository.vu.lt/VU:ELABAPDB126115449&prefLang=en_US |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) . |
| Dokumentencode: | edsair.doi.dedup.....67ab1cf3948019e1ba3e8b533248c5f3 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological–genetic model has exciting potential for studies of past human health and expansion into various other contexts. |
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| ISSN: | 10916490 00278424 |
| DOI: | 10.1073/pnas.2106743119 |