Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark
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| Názov: | Polypharmacy in antipsychotic pharmacological treatment among patients with dual diagnosis in Denmark |
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| Autori: | Lei Blandin Jobe, Solvej Mårtensson, Signe Wegmann Düring |
| Zdroj: | Nordic Journal of Psychiatry. 78:112-119 |
| Informácie o vydavateľovi: | Informa UK Limited, 2023. |
| Rok vydania: | 2023 |
| Predmety: | Dual (Psychiatry), Adult, Adolescent, Substance-Related Disorders, Denmark, Substance-Related Disorders/drug therapy, Middle Aged, Denmark/epidemiology, 3. Good health, Hospitalization, Young Adult, Diagnosis, Dual (Psychiatry), Diagnosis, Polypharmacy, Humans, Antipsychotic Agents/therapeutic use, Antipsychotic Agents |
| Popis: | Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations. Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions. The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013–2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41–50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18–30 years old. Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1502-4725 0803-9488 |
| DOI: | 10.1080/08039488.2023.2277820 |
| DOI: | 10.6084/m9.figshare.24525511 |
| DOI: | 10.6084/m9.figshare.24525511.v1 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37938028 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....643a6c1cd272f4713238d48c94b67902 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Antipsychotic polypharmacy is prevalent, however literature on antipsychotic polypharmacy during treatment among patients with dual diagnosis is largely non-existent. This study aims to investigating the extent of antipsychotic polypharmacy dual diagnosis patients during hospitalisations. Utilizing cohort data from an integrated dual diagnosis in-patient facility from patients hospitalized between 1 March 2012, to 31 December 2016, we compared the mean antipsychotic medication administered at admission and discharge and examined covariate associations with logistic regressions. The study identified 907 hospital admissions, of which 641 were the first for each patient during the period. At admission, 74.1% received antipsychotics; polypharmacy spanned psychiatric disorders. categories. Patients with affective or personality spectrum disorders were less likely to have antipsychotic polypharmacy upon admission compared to those with psychosis spectrum disorders. 2013–2016 admissions presented less polypharmacy than 2012. Mean antipsychotic numbers remained unchanged for >30-day hospitalizations. Patients admitted without antipsychotic polypharmacy with an affective spectrum disorder or aged 41–50 or over 51 years old were less likely to be discharged with antipsychotic polypharmacy when compared to patients with psychosis spectrum disorder or aged 18–30 years old. Approximately three-quarters of admitted patients were treated with antipsychotic medication. Antipsychotic polypharmacy was observed across all psychiatric disorder categories, indicating potential off-label use. Addressing antipsychotic polypharmacy during treatment is challenging, even for specialised facilities. Rational antipsychotic prescribing, deprescribing protocols, and further prescription pattern research are needed. |
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| ISSN: | 15024725 08039488 |
| DOI: | 10.1080/08039488.2023.2277820 |