Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods
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| Titel: | Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods |
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| Autoren: | Yong Taek Jeong, Haein Kim, Min Sung Choi, Jaekyun Choi, Seok Jun Moon, Jae Young Kwon |
| Weitere Verfasser: | College of Dentistry, Dept. of Oral Biology, Haein Kim, Yong Taek Jeong, Min Sung Choi, Jaekyun Choi, Seok Jun Moon, Jae Young Kwon, Moon, Seok Jun, Jeong, Yong Taek |
| Quelle: | Mol Cells |
| Verlagsinformationen: | Elsevier BV, 2017. |
| Publikationsjahr: | 2017 |
| Schlagwörter: | 0301 basic medicine, Drosophila Proteins/metabolism, Taste Buds/drug effects, Sensory Receptor Cells, Cell Surface/metabolism, Genetically Modified, Receptors, Cell Surface, Sodium Chloride, Article, Animals, Genetically Modified, 03 medical and health sciences, Drosophila Proteins/genetics, Pharynx/cytology, Receptors, Sensory Receptor Cells/physiology, Animals, Drosophila Proteins, Feeding Behavior/drug effects, 2. Zero hunger, 0303 health sciences, pharyngeal sense organ, Feeding Behavior, Taste Buds, gustatory receptor, Drosophila melanogaster, Gene Expression Regulation, Drosophila melanogaster/physiology, Cell Surface/genetics, Sensory Receptor Cells/cytology, Pharynx, RNA Interference, Sensory Receptor Cells/drug effects, feeding, Sodium Chloride/pharmacology |
| Beschreibung: | Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1016-8478 |
| DOI: | 10.14348/molcells.2017.0028 |
| Zugangs-URL: | http://www.molcells.org/journal/download_pdf.php?doi=10.14348/molcells.2017.0028 https://pubmed.ncbi.nlm.nih.gov/28535667 https://europepmc.org/abstract/MED/28535667 https://ir.ymlib.yonsei.ac.kr/handle/22282913/154257 https://www.e-sciencecentral.org/articles/SC000024893 https://pubmed.ncbi.nlm.nih.gov/28535667/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463041 https://www.ncbi.nlm.nih.gov/pubmed/28535667 |
| Rights: | CC BY NC SA CC BY NC ND |
| Dokumentencode: | edsair.doi.dedup.....639ff0fcebac35a5cbd737761b81484c |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner. |
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| ISSN: | 10168478 |
| DOI: | 10.14348/molcells.2017.0028 |