In EDS ansehen

Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey

Gespeichert in:
Bibliographische Detailangaben
Titel: Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey
Autoren: Faulhaber, Liv, Herget-Rosenthal, Stefan, Jacobs, Hannes, Hoffmann, Falk
Quelle: Kidney & Blood Pressure Research, Pp 1-10 (2021)
Verlagsinformationen: S. Karger AG, 2021.
Publikationsjahr: 2021
Schlagwörter: Surveys and Questionnaires [MeSH], Female [MeSH], Renal Insufficiency, Chronic/physiopathology [MeSH], Renal Insufficiency, Chronic/diagnosis [MeSH], Glomerular filtration rate, Health-related quality of life, Aged [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Germany/epidemiology [MeSH], Short form health Survey-36, Glomerular Filtration Rate [MeSH], Kidney/physiopathology [MeSH], Male [MeSH], Quality of Life [MeSH], Chronic kidney disease, Renal Insufficiency, Chronic/epidemiology [MeSH], Research Article, Adult, Male, short form health survey-36, Dermatology, Kidney, 03 medical and health sciences, 0302 clinical medicine, Germany, Surveys and Questionnaires, Diseases of the circulatory (Cardiovascular) system, Humans, Renal Insufficiency, Chronic, 10. No inequality, Aged, 2. Zero hunger, glomerular filtration rate, Middle Aged, 16. Peace & justice, Diseases of the genitourinary system. Urology, 3. Good health, health-related quality of life, RL1-803, RC666-701, Quality of Life, Female, RC870-923, chronic kidney disease, Glomerular Filtration Rate
Beschreibung: Background: Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a population-based sample of adults living in Germany. Methods: Data from the German health interview and examination survey conducted from 2008 to 2011 were used. Participants with valid interview and examination data aged 40–79 years were included (n = 5,159). Serum creatinine levels were used to calculate estimated GFR via the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We classified kidney function in GFR categories according to the Kidney Disease Improving Global Outcomes Initiative (KDIGO) guidelines on CKD: G1 (high): ≥90 mL/min/1.73 m2, G2 (normal): 60–89 mL/min/1.73 m2, G3a (mildly decreased): 45–59 mL/min/1.73 m2, G3b (moderately decreased): 30–44 mL/min/1.73 m2, G4/5 (severely decreased/end-stage kidney disease): 2. HRQoL was evaluated with the Short Form Health Survey (SF-36). Different multivariate linear and logistic regression models were used to analyze the association of HRQoL with GFR categories. Results: Overall, 5.9% had a GFR 2 (corresponding to categories G3a, G3b, and G4/5). Compared to category G2 linear regression showed a decline in physical HRQoL in categories G3a (−2.34, p = 0.004), G3b (−5.37, p = 0.009), and G4/5 (−4.82, p = 0.117). No decline in mental HRQoL was detected with increasing GFR categories. Categories G3a to G4/5 were significantly associated with a low perceived general state of health (G3a: odds ratio [OR] = 2.03, p = 0.001; G3b: OR = 3.01, p = 0.009; G4/5: OR = 8.70, p = 0.016) when compared to category G2. Conclusion: In a representative sample of adults living in Germany, both physical HRQoL and the perceived general state of health are already significantly reduced in category G3a.
Publikationsart: Article
Conference object
Sprache: English
ISSN: 1423-0143
1420-4096
DOI: 10.1159/000518668
Zugangs-URL: https://www.karger.com/Article/Pdf/518668
https://pubmed.ncbi.nlm.nih.gov/34818245
https://doaj.org/article/d86702cf2b9f4667b5a69893fbc5d3b7
https://repository.publisso.de/resource/frl:6439839
Rights: CC BY NC
Dokumentencode: edsair.doi.dedup.....639f3596999b5adf9489ac5e32c1cda6
Datenbank: OpenAIRE
Beschreibung
Abstract:Background: Most studies on health-related quality of life (HRQoL) in chronic kidney disease (CKD) focus on patients with end-stage kidney disease although they represent a small proportion of patients with CKD. We aimed to analyze HRQoL according to glomerular filtration rate (GFR) categories in a population-based sample of adults living in Germany. Methods: Data from the German health interview and examination survey conducted from 2008 to 2011 were used. Participants with valid interview and examination data aged 40–79 years were included (n = 5,159). Serum creatinine levels were used to calculate estimated GFR via the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We classified kidney function in GFR categories according to the Kidney Disease Improving Global Outcomes Initiative (KDIGO) guidelines on CKD: G1 (high): ≥90 mL/min/1.73 m2, G2 (normal): 60–89 mL/min/1.73 m2, G3a (mildly decreased): 45–59 mL/min/1.73 m2, G3b (moderately decreased): 30–44 mL/min/1.73 m2, G4/5 (severely decreased/end-stage kidney disease): 2. HRQoL was evaluated with the Short Form Health Survey (SF-36). Different multivariate linear and logistic regression models were used to analyze the association of HRQoL with GFR categories. Results: Overall, 5.9% had a GFR 2 (corresponding to categories G3a, G3b, and G4/5). Compared to category G2 linear regression showed a decline in physical HRQoL in categories G3a (−2.34, p = 0.004), G3b (−5.37, p = 0.009), and G4/5 (−4.82, p = 0.117). No decline in mental HRQoL was detected with increasing GFR categories. Categories G3a to G4/5 were significantly associated with a low perceived general state of health (G3a: odds ratio [OR] = 2.03, p = 0.001; G3b: OR = 3.01, p = 0.009; G4/5: OR = 8.70, p = 0.016) when compared to category G2. Conclusion: In a representative sample of adults living in Germany, both physical HRQoL and the perceived general state of health are already significantly reduced in category G3a.
ISSN:14230143
14204096
DOI:10.1159/000518668