Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats
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| Názov: | Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats |
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| Autori: | Adam Hermanowicz, Wlodzimierz Buczko, Piotr Buczko, Justyna Magdalena Hermanowicz, Anna Tankiewicz-Kwedlo |
| Zdroj: | Pharmacological Reports. 67:173-178 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2015. |
| Rok vydania: | 2015 |
| Predmety: | Male, Platelet Aggregation, Blood Pressure, Thrombosis - complications, Disease models, Hemostasis - drug effects, Hypertension - complications, Amides - pharmacology, 03 medical and health sciences, Hypertension - drug therapy, 0302 clinical medicine, Fumarates, Plasminogen Activator Inhibitor 1, Blood coagulation - drug effects, Animals, animal, Plasminogen activator inhibitor 1 - blood, Antihypertensive agents - therapeutic use, Blood Coagulation, Antihypertensive Agents, Blood coagulation factors - drug effects, Thrombosis - blood, Amides - therapeutic use, Hemostasis, Tissue plasminogen activator - blood, Blood pressure - drug effects, Thrombosis, Thrombosis - drug therapy, Amides, Blood Coagulation Factors, Rats, 3. Good health, Disease Models, Animal, Platelet aggregation - drug effects, Antihypertensive agents - pharmacology, Tissue Plasminogen Activator, Fumarates - pharmacology, Hypertension, Fumarates - therapeutic use |
| Popis: | Aliskiren is the first orally active inhibitor of renin to be approved for clinical use as an antihypertensive agent. A number of studies show a link between aliskiren and intravascular thrombosis.The goal of the present study was to investigate the impact of aliskiren on arterial thrombosis in normotensive and renovascular hypertensive rats. The contribution of each coagulation and fibrinolytic parameters in the mode of aliskiren action was determined. Six weeks after clipping of the left renal artery rats developed hypertension which was confirmed by the "tail cuff" method. Animals were treated with aliskiren (10, 30 and 100mg/kg/day) per os for 10 days. Arterial thrombosis was induced by electrical stimulation of the common carotid artery.It was found that aliskiren in a dose-dependent manner decreased weight of the arterial thrombus in normotensive and hypertensive rats. It has been shown that this result was not associated with the effects on blood pressure, TF, PT, APTT, fibrinogen and hematological parameters. It was found that aliskiren caused increase of t-PA activity and decrease of its inhibitor activity.The presented results indicate that aliskiren inhibits hemostasis in the arterial thrombosis in rats. The antithrombotic effect is related with improvement of the fibrinolytic balance, and also depends on antiplatelet action. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/j.pharep.2014.08.021 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/25712636 https://www.sciencedirect.com/science/article/pii/S1734114014002825#! https://pubmed.ncbi.nlm.nih.gov/25712636/ https://www.ncbi.nlm.nih.gov/pubmed/25712636 https://www.sciencedirect.com/science/article/pii/S1734114014002825 https://europepmc.org/article/MED/25712636 https://link.springer.com/article/10.1016/j.pharep.2014.08.021 |
| Rights: | Elsevier TDM |
| Prístupové číslo: | edsair.doi.dedup.....6378ad4a27934e3150d5b7390bd576a4 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Aliskiren is the first orally active inhibitor of renin to be approved for clinical use as an antihypertensive agent. A number of studies show a link between aliskiren and intravascular thrombosis.The goal of the present study was to investigate the impact of aliskiren on arterial thrombosis in normotensive and renovascular hypertensive rats. The contribution of each coagulation and fibrinolytic parameters in the mode of aliskiren action was determined. Six weeks after clipping of the left renal artery rats developed hypertension which was confirmed by the "tail cuff" method. Animals were treated with aliskiren (10, 30 and 100mg/kg/day) per os for 10 days. Arterial thrombosis was induced by electrical stimulation of the common carotid artery.It was found that aliskiren in a dose-dependent manner decreased weight of the arterial thrombus in normotensive and hypertensive rats. It has been shown that this result was not associated with the effects on blood pressure, TF, PT, APTT, fibrinogen and hematological parameters. It was found that aliskiren caused increase of t-PA activity and decrease of its inhibitor activity.The presented results indicate that aliskiren inhibits hemostasis in the arterial thrombosis in rats. The antithrombotic effect is related with improvement of the fibrinolytic balance, and also depends on antiplatelet action. |
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| ISSN: | 17341140 |
| DOI: | 10.1016/j.pharep.2014.08.021 |