Diagnostic and prognostic value of inflammatory indices in patients with prediabetes and type 2 diabetes mellitus
Uloženo v:
| Název: | Diagnostic and prognostic value of inflammatory indices in patients with prediabetes and type 2 diabetes mellitus |
|---|---|
| Autoři: | Z.O. Shaienko, H.Yu. Morokhovets |
| Zdroj: | Mìžnarodnij Endokrinologìčnij Žurnal, Vol 21, Iss 3, Pp 259-264 (2025) |
| Informace o vydavateli: | Publishing House Zaslavsky, 2025. |
| Rok vydání: | 2025 |
| Témata: | systemic inflammation, type 2 diabetes mellitus, diagnosis, systemic inflammatory indices, prediabetes, RC648-665, Diseases of the endocrine glands. Clinical endocrinology |
| Popis: | Background. Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation, which significantly contributes to the development of insulin resistance and progressive metabolic dysfunction. Inflammatory indices derived from complete blood count parameters may serve as accessible and cost-effective tools for assessing meta-inflammation. Objective: to determine the levels of systemic immune-inflammation index (SII) and systemic immune-inflammation response index (SIRI) in patients with prediabetes and T2DM in order to assess their diagnostic and prognostic value. Materials and methods. This study included 60 participants divided into three groups: type 2 diabetes, prediabetes, and a control group. The levels of SII, SIRI, HbA1c, arginase, inducible nitric oxide synthase, and other metabolic markers were measured. Statistical methods included Kruskal-Wallis test, receiver operating characteristic (ROC) analysis, principal component analysis (PCA), and Spearman correlation. Results. SII was significantly elevated in the T2DM group compared to both the control (p = 0.008) and the prediabetes group (p = 0.2414), indicating the progression of systemic inflammation alongside glycemic dysregulation. Although SIRI did not demonstrate significant between-group differences, it showed a strong correlation with SII in the T2DM group (R = 0.72; p |
| Druh dokumentu: | Article |
| ISSN: | 2307-1427 2224-0721 |
| DOI: | 10.22141/2224-0721.21.3.2025.1536 |
| Přístupová URL adresa: | https://doaj.org/article/e84aa485dfb047b2a743c22b61394406 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....62858cb8b1cd1a455fe23d6c3347dba2 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background. Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation, which significantly contributes to the development of insulin resistance and progressive metabolic dysfunction. Inflammatory indices derived from complete blood count parameters may serve as accessible and cost-effective tools for assessing meta-inflammation. Objective: to determine the levels of systemic immune-inflammation index (SII) and systemic immune-inflammation response index (SIRI) in patients with prediabetes and T2DM in order to assess their diagnostic and prognostic value. Materials and methods. This study included 60 participants divided into three groups: type 2 diabetes, prediabetes, and a control group. The levels of SII, SIRI, HbA1c, arginase, inducible nitric oxide synthase, and other metabolic markers were measured. Statistical methods included Kruskal-Wallis test, receiver operating characteristic (ROC) analysis, principal component analysis (PCA), and Spearman correlation. Results. SII was significantly elevated in the T2DM group compared to both the control (p = 0.008) and the prediabetes group (p = 0.2414), indicating the progression of systemic inflammation alongside glycemic dysregulation. Although SIRI did not demonstrate significant between-group differences, it showed a strong correlation with SII in the T2DM group (R = 0.72; p |
|---|---|
| ISSN: | 23071427 22240721 |
| DOI: | 10.22141/2224-0721.21.3.2025.1536 |