In EDS ansehen

Micro- and nanoplastics concepts for particle and fibre toxicologists

Gespeichert in:
Bibliographische Detailangaben
Titel: Micro- and nanoplastics concepts for particle and fibre toxicologists
Autoren: Wright, Stephanie, Cassee, Flemming R, Erdely, Aaron, Campen, Matthew J
Weitere Verfasser: IRAS OH Toxicology, IRAS – One Health Toxicology, RIVM Publications Repository, Open Repository DS7.6 Demo
Quelle: Part Fibre Toxicol
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-6 (2024)
Verlagsinformationen: Springer Science and Business Media LLC, 2024.
Publikationsjahr: 2024
Schlagwörter: Particulate Matter/toxicity, 0301 basic medicine, 0303 health sciences, Health, Toxicology and Mutagenesis, Microplastics, Comment, HD7260-7780.8, Toxicology, Microplastics/toxicity, Plastics/toxicity, Nanostructures, 03 medical and health sciences, RA1190-1270, Toxicology. Poisons, Humans, Polystyrenes, Industrial hygiene. Industrial welfare, Particulate Matter, Plastics
Beschreibung: Micro- and nanoplastic particles (MNP) are omnipresent as either pollution or intentionally used in consumer products, released from packaging or even food. There is an exponential increase in the production of plastics. With the realization of bioaccumulation in humans, toxicity research is quickly expanding. There is a rapid increase in the number of papers published on the potential implications of exposure to MNP which necessitates a call for quality criteria to be applied when doing the research. At present, most papers on MNP describe the effects of commercially available polymer (mostly polystyrene) beads that are typically not the MNP of greatest concern. This is not a fault of the research community, necessarily, as the MNPs to which humans are exposed are usually not available in the quantities needed for toxicological research and innovations are needed to supply environmentally-relevant MNP models. In addition, like we have learned from decades of research with particulate matter and engineered nanomaterials, sample physicochemical characteristics and preparation can have major impacts on the biological responses and interpretation of the research findings. Lastly, MNP dosimetry may pose challenges as (1) we are seeing early evidence that plastics are already in the human body at quite high levels that may be difficult to achieve in acute in vitro studies and (2) plastics are already in the diets fed to preclinical models. This commentary highlights the pitfalls and recommendations for particle and fibre toxicologists that should be considered when performing and disseminating the research.
Publikationsart: Article
Other literature type
Report
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1743-8977
DOI: 10.1186/s12989-024-00581-x
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38566142
https://doaj.org/article/1cc4cdd8ca4a418b887b52ab3780e2c7
https://research-portal.uu.nl/en/publications/3dc918ae-6e9b-4681-8c75-e31eaa6ac889
https://doi.org/10.1186/s12989-024-00581-x
https://dspace.library.uu.nl/handle/1874/438341
https://rivm.openrepository.com/handle/10029/655036
https://hdl.handle.net/10029/627507
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Dokumentencode: edsair.doi.dedup.....60e0b49911d4baa29a47f30f42886eb4
Datenbank: OpenAIRE
Beschreibung
Abstract:Micro- and nanoplastic particles (MNP) are omnipresent as either pollution or intentionally used in consumer products, released from packaging or even food. There is an exponential increase in the production of plastics. With the realization of bioaccumulation in humans, toxicity research is quickly expanding. There is a rapid increase in the number of papers published on the potential implications of exposure to MNP which necessitates a call for quality criteria to be applied when doing the research. At present, most papers on MNP describe the effects of commercially available polymer (mostly polystyrene) beads that are typically not the MNP of greatest concern. This is not a fault of the research community, necessarily, as the MNPs to which humans are exposed are usually not available in the quantities needed for toxicological research and innovations are needed to supply environmentally-relevant MNP models. In addition, like we have learned from decades of research with particulate matter and engineered nanomaterials, sample physicochemical characteristics and preparation can have major impacts on the biological responses and interpretation of the research findings. Lastly, MNP dosimetry may pose challenges as (1) we are seeing early evidence that plastics are already in the human body at quite high levels that may be difficult to achieve in acute in vitro studies and (2) plastics are already in the diets fed to preclinical models. This commentary highlights the pitfalls and recommendations for particle and fibre toxicologists that should be considered when performing and disseminating the research.
ISSN:17438977
DOI:10.1186/s12989-024-00581-x