Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
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| Název: | Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats |
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| Autoři: | Han, Xiao, Li, Nanxin, Xue, Xiaofang, Shao, Feng, Wang, Weiwen, Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| Zdroj: | Brain Research. 1447:38-43 |
| Informace o vydavateli: | Elsevier BV, 2012. |
| Rok vydání: | 2012 |
| Témata: | Male, Social isolation, Receptors, Dopamine D2, Age Factors, Prefrontal Cortex, Neural Inhibition, Dopamine D2 receptor, Medial prefrontal cortex, Physiological Psychology/biological Psychology, Nucleus Accumbens, Adolescence, Rats, 3. Good health, Rats, Sprague-Dawley, Inhibition, Psychological, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Gene Expression Regulation, Social Isolation, Latent inhibition, Nucleus accumbens, Animals, 10. No inequality |
| Popis: | Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (LI) and dopamine D2 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2012.01.058 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/22341870 https://www.ncbi.nlm.nih.gov/pubmed/22341870 https://core.ac.uk/display/155435701 https://pubmed.ncbi.nlm.nih.gov/22341870/ https://www.sciencedirect.com/science/article/pii/S0006899312001618 http://ir.psych.ac.cn/handle/311026/11481 |
| Rights: | Elsevier TDM |
| Přístupové číslo: | edsair.doi.dedup.....5fff14ac73ff7dad6a5b593da32daab0 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (LI) and dopamine D2 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. |
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| ISSN: | 00068993 |
| DOI: | 10.1016/j.brainres.2012.01.058 |