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Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation

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Titel: Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation
Autoren: Yumei Huo, Beibei Chen, Xiaoyu Ren, Chao Wang, Rupeng Qi, Zhaoqing Xu
Quelle: Green Synthesis and Catalysis, Vol 6, Iss 1, Pp 114-118 (2025)
Verlagsinformationen: Elsevier BV, 2025.
Publikationsjahr: 2025
Schlagwörter: Photo reaction, Chemical technology, Asymmetric catalysis, Heterobenzylic amines, C(sp3)-H alkylation, TP1-1185, QD415-436, Biochemistry
Beschreibung: The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities. The enantioselective C(sp3)-H alkylation of heterobenzylic amines is an important strategy for the synthesis of α-alkylate chiral heterobenzylic amines. Herein, we disclose the first example of photoinduced and Cu-catalyzed enantioselective decarboxylative C(sp3)-H alkylation of oxadiazole methylamines.
Publikationsart: Article
Sprache: English
ISSN: 2666-5549
DOI: 10.1016/j.gresc.2023.11.004
Zugangs-URL: https://doaj.org/article/3ce38186a5b3452f99d930b7ed2be2b8
Rights: CC BY NC ND
Dokumentencode: edsair.doi.dedup.....5f0b2d89c63d8d70cf13ea0a5db8a03b
Datenbank: OpenAIRE
Beschreibung
Abstract:The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities. The enantioselective C(sp3)-H alkylation of heterobenzylic amines is an important strategy for the synthesis of α-alkylate chiral heterobenzylic amines. Herein, we disclose the first example of photoinduced and Cu-catalyzed enantioselective decarboxylative C(sp3)-H alkylation of oxadiazole methylamines.
ISSN:26665549
DOI:10.1016/j.gresc.2023.11.004