Evidence‐based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology
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| Název: | Evidence‐based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology |
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| Autoři: | Ilaria Girolami, Ersilia Lucenteforte, Albino Eccher, Stefano Marletta, Matteo Brunelli, Paolo Graziano, Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone, Aldo Scarpa, Tao Huang, Liron Pantanowitz |
| Zdroj: | Cancer Cytopathology. 130:96-109 |
| Informace o vydavateli: | Wiley, 2021. |
| Rok vydání: | 2021 |
| Témata: | Mesothelioma, Lung Neoplasms, diagnostic specificity and sensitivity, Pleural Neoplasms, Oncology and Hematology, 03 medical and health sciences, 0302 clinical medicine, systematic review, Health Sciences, effusion, Biomarkers, Tumor, Humans, In Situ Hybridization, Fluorescence, Sequence Deletion, Glucose Transporter Type 1, Homozygote, Mesothelioma, Malignant, 3. Good health, meta-analysis, pleura, meta‐analysis, biomarker, cytology, immunohistochemistry, mesothelioma |
| Popis: | Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and cytology samples preclude an assessment for pleural tissue invasion. Accordingly, immunohistochemical, soluble, and molecular biomarkers have been developed. The aim of this study is to provide quantitative evidence regarding the diagnostic performance of novel biomarkers. To that end, a systematic literature review was performed of articles dealing with a loss of BRCA1‐associated protein 1 (BAP1), methylthioadenosine (MTAP), 5‐hydroxymethylcitosine (5‐hmC), glucose transporter 1 (GLUT1), insulin like‐growth factor II messenger RNA–binding protein 3 (IMP3), enhanced zeste homologue 2 (EZH2) staining, cyclin‐dependent kinase inhibitor 2A (CDKN2A) homozygous deletion (HD) testing, soluble mesothelin, and microRNA quantification in cytological samples for the diagnosis of MPM versus reactive atypical mesothelial cells. Sensitivity and specificity were extracted, and a meta‐analysis was performed. The quality of the studies was assessed with Quality Assessment of Diagnostic Accuracy Studies 2, and the quality of the evidence was evaluated with the Grading of Recommendations Assessment, Development, and Evaluation approach. Seventy‐one studies were included. BAP1 loss showed a sensitivity of 0.65 (confidence interval [CI], 0.59‐0.71) and a specificity of 0.99 (CI, 0.93‐1.00). MTAP loss and p16 HD showed 100% specificity with sensitivities of 0.47 (CI, 0.38‐0.57) and 0.62 (CI, 0.53‐0.71), respectively. BAP1 loss and CDKN2A HD combined showed maximal specificity and a sensitivity of 0.83 (CI, 0.78‐0.89). GLUT1 and IMP3 showed sensitivities of 0.82 (CI, 0.70‐0.90) and 0.65 (CI, 0.41‐0.90), respectively, with comparable specificity. Mesothelin showed a sensitivity of 0.73 (CI, 0.68‐0.77) and a specificity of 0.90 (CI, 0.84‐0.93). In conclusion, some of the recently emerging biomarkers are close to 1.00 specificity. Their moderate sensitivity on their own, however, can be significantly improved by the use of 2 biomarkers, such as a combination of BAP1 and CDKN2A with fluorescence in situ hybridization or a combination of BAP1 and MTAP immunohistochemistry. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1934-6638 1934-662X |
| DOI: | 10.1002/cncy.22509 |
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| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/34478240 http://hdl.handle.net/11588/856741 https://iris.univr.it/handle/11562/1048321 https://pubmed.ncbi.nlm.nih.gov/34478240/ https://moh-it.pure.elsevier.com/en/publications/evidence-based-diagnostic-performance-of-novel-biomarkers-for-the http://www.ncbi.nlm.nih.gov/pubmed/34478240 https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncy.22509 |
| Rights: | Wiley Online Library User Agreement CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....5ddd401f01d98c7af04ac19efc0f5130 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and cytology samples preclude an assessment for pleural tissue invasion. Accordingly, immunohistochemical, soluble, and molecular biomarkers have been developed. The aim of this study is to provide quantitative evidence regarding the diagnostic performance of novel biomarkers. To that end, a systematic literature review was performed of articles dealing with a loss of BRCA1‐associated protein 1 (BAP1), methylthioadenosine (MTAP), 5‐hydroxymethylcitosine (5‐hmC), glucose transporter 1 (GLUT1), insulin like‐growth factor II messenger RNA–binding protein 3 (IMP3), enhanced zeste homologue 2 (EZH2) staining, cyclin‐dependent kinase inhibitor 2A (CDKN2A) homozygous deletion (HD) testing, soluble mesothelin, and microRNA quantification in cytological samples for the diagnosis of MPM versus reactive atypical mesothelial cells. Sensitivity and specificity were extracted, and a meta‐analysis was performed. The quality of the studies was assessed with Quality Assessment of Diagnostic Accuracy Studies 2, and the quality of the evidence was evaluated with the Grading of Recommendations Assessment, Development, and Evaluation approach. Seventy‐one studies were included. BAP1 loss showed a sensitivity of 0.65 (confidence interval [CI], 0.59‐0.71) and a specificity of 0.99 (CI, 0.93‐1.00). MTAP loss and p16 HD showed 100% specificity with sensitivities of 0.47 (CI, 0.38‐0.57) and 0.62 (CI, 0.53‐0.71), respectively. BAP1 loss and CDKN2A HD combined showed maximal specificity and a sensitivity of 0.83 (CI, 0.78‐0.89). GLUT1 and IMP3 showed sensitivities of 0.82 (CI, 0.70‐0.90) and 0.65 (CI, 0.41‐0.90), respectively, with comparable specificity. Mesothelin showed a sensitivity of 0.73 (CI, 0.68‐0.77) and a specificity of 0.90 (CI, 0.84‐0.93). In conclusion, some of the recently emerging biomarkers are close to 1.00 specificity. Their moderate sensitivity on their own, however, can be significantly improved by the use of 2 biomarkers, such as a combination of BAP1 and CDKN2A with fluorescence in situ hybridization or a combination of BAP1 and MTAP immunohistochemistry. |
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| ISSN: | 19346638 1934662X |
| DOI: | 10.1002/cncy.22509 |