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Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

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Názov: Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
Autori: Guintivano J, Byrne EM, Kiewa J, Yao S, Bauer AE, Aberg KA, Adams MJ, Campbell A, Campbell ML, Choi KW, Corfield EC, Havdahl A, Hucks D, Koen N, Lu Y, Mægbæk ML, Mullaert J, Peterson RE, Raffield LM, Sallis HM, Sealock JM, Walker A, Watson HJ, Xiong Y, Yang JMK, Anney RJL, Gordon-Smith K, Hubbard L, Jones LA, Mihaescu R, Nyegaard M, Pardiñas AF, Perry A, Saquib N, Shadyab AH, Viktorin A, Andreassen OA, Bigdeli TB, Davis LK, Dennis CL, Di Florio A, Dubertret C, Feng YA, Frey BN, Grigoriadis S, Gloaguen E, Jones I, Kennedy JL, Krohn H, Kunovac Kallak T, Li Y, Martin NG, McIntosh AM, Milgrom J, Munk-Olsen T, Oberlander T, Olsen CM, Ramoz N, Reichborn-Kjennerud T, Robertson Blackmore E, Rubinow D, Skalkidou A, Smoller JW, Stein DJ, Stowe ZN, Taylor V, Tebeka S, Tesli M, Van Lieshout RJ, van den Oord EJCG, Vigod SN, Werge T, Westlye LT, Whiteman DC, Zar HJ, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray N, Meltzer-Brody S, Sullivan P
Zdroj: Guintivano, J, Byrne, E M, Kiewa, J, Yao, S, Bauer, A E, Aberg, K A, Adams, M J, Campbell, A, Campbell, M L, Choi, K W, Corfield, E C, Havdahl, A, Hucks, D, Koen, N, Lu, Y, Mægbæk, M L, Mullaert, J, Peterson, R E, Raffield, L M, Sallis, H M, Sealock, J M, Walker, A, Watson, H J, Xiong, Y, Yang, J M K, Anney, R J L, Gordon-Smith, K, Hubbard, L, Jones, L A, Mihaescu, R, Nyegaard, M, Pardiñas, A F, Perry, A, Saquib, N, Shadyab, A H, Viktorin, A, Andreassen, O A, Bigdeli, T B, Davis, L K, Dennis, C-L, Di Florio, A, Dubertret, C, Feng, Y-C A, Frey, B N, Grigoriadis, S, Gloaguen, E, Jones, I, Kennedy, J L, Krohn, H, Kunovac Kallak, T, Li, Y, Martin, N G, McIntosh, A M, Milgrom, J, Munk-Olsen, T, Oberlander, T, Olsen, C M, Ramoz, N, Reichborn-Kjennerud, T, Robertson Blackmore, E, Rubinow, D, Skalkidou, A, Smoller, J W, Stein, D J, Stowe, Z N, Taylor, V, Tebeka, S, Tesli, M, Van Lieshout, R J, van den Oord, E J C G, Vigod, S N, Werge, T, Westlye, L T, Whiteman, D C, Zar, H J, Wray, N, Meltzer-Brody, S, Sullivan, P & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2023, 'Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression', The American Journal of Psychiatry, vol. 180, no. 12, pp. 884-895. https://doi.org/10.1176/appi.ajp.20230053
Guintivano, J, Byrne, E M, Kiewa, J, Yao, S, Bauer, A E, Aberg, K A, Adams, M J, Campbell, A, Campbell, M L, Choi, K W, Corfield, E C, Havdahl, A, Hucks, D, Koen, N, Lu, Y, Mægbæk, M L, Mullaert, J, Peterson, R E, Raffield, L M, Sallis, H M, Sealock, J M, Walker, A, Watson, H J, Xiong, Y, Yang, J M K, Anney, R J L, Gordon-Smith, K, Hubbard, L, Jones, L A, Mihaescu, R, Nyegaard, M, Pardiñas, A F, Perry, A, Saquib, N, Shadyab, A H, Viktorin, A, Andreassen, O A, Bigdeli, T B, Davis, L K, Dennis, C-L, Di Florio, A, Dubertret, C, Feng, Y-C A, Frey, B N, Grigoriadis, S, Gloaguen, E, Jones, I, Kennedy, J L, Krohn, H, Kunovac Kallak, T, Li, Y, Martin, N G, McIntosh, A M, Milgrom, J, Munk-Olsen, T, Oberlander, T, Olsen, C M, Ramoz, N, Reichborn-Kjennerud, T, Robertson Blackmore, E, Rubinow, D, Skalkidou, A, Smoller, J W, Stein, D J, Stowe, Z N, Taylor, V, Tebeka, S, Tesli, M, Van Lieshout, R J, van den Oord, E J C G, Vigod, S N, Werge, T, Westlye, L T, Whiteman, D C, Zar, H J, Wray, N, Meltzer-Brody, S, Sullivan, P & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression ', The American Journal of Psychiatry, vol. 180, no. 12, pp. 884-895 . https://doi.org/10.1176/appi.ajp.20230053
Guintivano, J, Byrne, E M, Kiewa, J, Yao, S, Bauer, A E, Aberg, K A, Adams, M J, Campbell, A, Campbell, M L, Choi, K W, Corfield, E C, Havdahl, A, Hucks, D, Koen, N, Lu, Y, Mægbæk, M L, Mullaert, J, Peterson, R E, Raffield, L M, Sallis, H M, Sealock, J M, Walker, A, Watson, H J, Xiong, Y, Yang, J M K, Anney, R J L, Gordon-Smith, K, Hubbard, L, Jones, L A, Mihaescu, R, Nyegaard, M, Pardiñas, A F, Perry, A, Saquib, N, Shadyab, A H, Viktorin, A, Andreassen, O A, Bigdeli, T B, Davis, L K, Dennis, C-L, Di Florio, A, Dubertret, C, Feng, Y-C A, Frey, B N, Grigoriadis, S, Gloaguen, E, Jones, I, Kennedy, J L, Krohn, H, Kallak, T K, Li, Y, Martin, N G, McIntosh, A M, Milgrom, J, Munk-Olsen, T, Oberlander, T, Olsen, C M, Ramoz, N, Reichborn-Kjennerud, T, Blackmore, E R, Rubinow, D, Skalkidou, A, Smoller, J W, Stein, D J, Stowe, Z N, Taylor, V, Tebeka, S, Tesli, M, Van Lieshout, R J, van den Oord, E J C G, Vigod, S N, Werge, T, Westlye, L T, Whiteman, D C, Zar, H J, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, N, Meltzer-Brody, S & Sullivan, P 2023, ' Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression ', The American Journal of Psychiatry, vol. 180, no. 12, pp. 884-895 . https://doi.org/10.1176/appi.ajp.20230053
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2023, 'Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression', The American Journal of Psychiatry (Spanish Edition), vol. 180, no. 12, pp. 884-895. https://doi.org/10.1176/appi.ajp.20230053
American Journal of Psychiatry
Informácie o vydavateľovi: American Psychiatric Association Publishing, 2023.
Rok vydania: 2023
Predmety: Depressive Disorder, Depressive Disorder, Major, Bipolar Disorder, Depression, Bipolar Disorder/genetics, Major/genetics, Polymorphism, Single Nucleotide/genetics, Polymorphism, Single Nucleotide, 3. Good health, Depression, Postpartum, Mice, Depression, Postpartum/genetics, Humans, Animals, Female, Genetic Predisposition to Disease, Polymorphism, Depressive Disorder, Major/genetics, Single Nucleotide/genetics, Postpartum/genetics, Genome-Wide Association Study
Popis: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS findings in 27 human tissues and 265 cell types from the mouse central and peripheral nervous system.No SNP achieved genome-wide significance in the European or the trans-ancestry meta-analyses. The [Formula: see text] of PPD was 0.14 (SE=0.02). Significant genetic correlations were estimated for PPD with MDD, bipolar disorder, anxiety disorders, posttraumatic stress disorder, insomnia, age at menarche, and polycystic ovary syndrome. Cell-type enrichment analyses implicate inhibitory neurons in the thalamus and cholinergic neurons within septal nuclei of the hypothalamus, a pattern that differs from MDD.While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
Druh dokumentu: Article
Popis súboru: application/pdf
Jazyk: English
ISSN: 1535-7228
0002-953X
DOI: 10.1176/appi.ajp.20230053
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37849304
https://vbn.aau.dk/ws/files/748913695/ppd_gwas_20230627_2_.pdf
https://doi.org/10.1176/appi.ajp.20230053
https://vbn.aau.dk/da/publications/feb2ef31-4d1d-459c-94c3-26351d1659ec
https://curis.ku.dk/ws/files/385232389/ppd_gwas_20230627_2_.pdf
https://pure.au.dk/portal/en/publications/0523c611-f9ce-4b87-af4a-d7b181601cae
https://doi.org/10.1176/appi.ajp.20230053
https://pmc.ncbi.nlm.nih.gov/articles/PMC11163373/pdf/nihms-1987810.pdf
https://publications.scilifelab.se/publication/81b93732cab9499a9aa99d87d2b3d294
Prístupové číslo: edsair.doi.dedup.....5d6f0f27ce70d62324aa417e7c3f3997
Databáza: OpenAIRE
Popis
Abstrakt:Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS findings in 27 human tissues and 265 cell types from the mouse central and peripheral nervous system.No SNP achieved genome-wide significance in the European or the trans-ancestry meta-analyses. The [Formula: see text] of PPD was 0.14 (SE=0.02). Significant genetic correlations were estimated for PPD with MDD, bipolar disorder, anxiety disorders, posttraumatic stress disorder, insomnia, age at menarche, and polycystic ovary syndrome. Cell-type enrichment analyses implicate inhibitory neurons in the thalamus and cholinergic neurons within septal nuclei of the hypothalamus, a pattern that differs from MDD.While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
ISSN:15357228
0002953X
DOI:10.1176/appi.ajp.20230053