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Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders

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Název: Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders
Autoři: Jairo M. González-Díaz, Bernardo Sánchez Dalmau, Anna Camós-Carreras, Salut Alba-Arbalat, Silvia Amoretti, Maria Florencia Forte, Maria Serra-Navarro, Sergi Salmerón, Anaid Pérez-Ramos, Eduard Vieta, Carla Torrent, Miquel Bernardo
Přispěvatelé: Institut Català de la Salut, [González-Díaz JM] UR Center for Mental Health, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Clinica Nuestra Señora de la Paz – OHSJD, Bogota, Colombia. Barcelona Clinic Schizophrenia Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain. Department of Medicine, School of Medicine, Institute of Neurosciences – UBNeuro, University of Barcelona, Barcelona, Spain. [Sánchez Dalmau B] Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. [Camós-Carreras A] Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. [Alba-Arbalat S] Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Department of Neurology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. [Amoretti S] Barcelona Clinic Schizophrenia Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Forte MF] Institut d'Investigacions Mèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic, Barcelona, Spain. Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Zdroj: Articles publicats en revistes (Medicina)
Dipòsit Digital de la UB
instname
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Informace o vydavateli: Elsevier BV, 2025.
Rok vydání: 2025
Témata: Retina - Imatgeria, Male, Adult, Tomografia, Psicosi, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::espectro de la esquizofrenia y otros trastornos psicóticos::esquizofrenia, Retina, Young Adult, Cognition, ANATOMÍA::órganos de los sentidos::ojo::retina, Tomografia de coherència òptica, Humans, ANATOMY::Sense Organs::Eye::Retina, Tomography, Schizophrenia spectrum and other psychotic disorders, Àrees temàtiques de la UPC::Ciències de la visió, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Schizophrenia Spectrum and Other Psychotic Disorders::Schizophrenia, Optical coherence, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Psychoses, Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia, Early Diagnosis, Cross-Sectional Studies, Mental illness, Spain, Esquizofrènia - Imatgeria, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica, Schizophrenia, Esquizofrènia, Female, Schizophrenic Psychology, Malalties mentals, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence, Biomarkers, Tomography, Optical Coherence
Popis: Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included. Retinal structure was evaluated using Spectral-Domain Optical Coherence Tomography (SD-OCT), focusing on the peripapillary retinal nerve fiber layer (pRNFL), macular volume/thickness, and ganglion cell-inner plexiform layer (GCL+IPL) thickness. Although SSD cases showed increased peripapillary retinal nerve fiber layer (pRNFL) thickness in specific quadrants, most retinal parameters did not differ significantly between groups. Preliminary associations were observed between retinal measures, premorbid adjustment, DUP, and cognitive performance. These findings, while suggesting the potential of retinal imaging as a tool for early detection and monitoring of psychotic disorders, must be interpreted with caution. Further longitudinal and multimodal research is warranted to explore the association between these retinal changes and neuroinflammation, neurodegeneration, and overall brain health in SSD patients.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2024.12.006
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39718075
https://hdl.handle.net/2445/220088
http://hdl.handle.net/11351/12747
Rights: CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....5ceb0892a7aa4c74668eb80821d929f7
Databáze: OpenAIRE
Popis
Abstrakt:Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included. Retinal structure was evaluated using Spectral-Domain Optical Coherence Tomography (SD-OCT), focusing on the peripapillary retinal nerve fiber layer (pRNFL), macular volume/thickness, and ganglion cell-inner plexiform layer (GCL+IPL) thickness. Although SSD cases showed increased peripapillary retinal nerve fiber layer (pRNFL) thickness in specific quadrants, most retinal parameters did not differ significantly between groups. Preliminary associations were observed between retinal measures, premorbid adjustment, DUP, and cognitive performance. These findings, while suggesting the potential of retinal imaging as a tool for early detection and monitoring of psychotic disorders, must be interpreted with caution. Further longitudinal and multimodal research is warranted to explore the association between these retinal changes and neuroinflammation, neurodegeneration, and overall brain health in SSD patients.
ISSN:0924977X
DOI:10.1016/j.euroneuro.2024.12.006