The epidemiology of bloodstream infections and antimicrobial susceptibility patterns in Thuringia, Germany: a five-year prospective, state-wide surveillance study (AlertsNet)
Uloženo v:
| Název: | The epidemiology of bloodstream infections and antimicrobial susceptibility patterns in Thuringia, Germany: a five-year prospective, state-wide surveillance study (AlertsNet) |
|---|---|
| Autoři: | Franziska Schöneweck, Roland P. H. Schmitz, Florian Rißner, André Scherag, Bettina Löffler, Mathias W. Pletz, Sebastian Weis, Frank M. Brunkhorst, Stefan Hagel |
| Zdroj: | Antimicrob Resist Infect Control Antimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-9 (2021) |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2021. |
| Rok vydání: | 2021 |
| Témata: | Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, Epidemiology, Enterococcus faecium, MRSA, Infectious and parasitic diseases, RC109-216, 03 medical and health sciences, Germany, Sepsis, Escherichia coli, Staphylococcus epidermidis, Humans, Prospective Studies, Aged, Candida, Aged, 80 and over, 0303 health sciences, Surveillance, Research, Drug Resistance, Microbial, Vancomycin Resistance, Middle Aged, 16. Peace & justice, 3. Good health, Sepsis/microbiology [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Vancomycin Resistance [MeSH], Germany/epidemiology [MeSH], Sepsis/epidemiology [MeSH], Klebsiella pneumoniae/drug effects [MeSH], Methicillin-Resistant Staphylococcus aureus/physiology [MeSH], Methicillin Resistance [MeSH], Escherichia coli/drug effects [MeSH], Humans [MeSH], Prospective Studies [MeSH], Candida/drug effects [MeSH], Middle Aged [MeSH], Bloodstream infections, Carbapenems/pharmacology [MeSH], Sepsis/drug therapy [MeSH], Drug Resistance, Microbial [MeSH], Staphylococcus epidermidis/drug effects [MeSH], Enterococcus faecium/drug effects [MeSH], ESBL, Klebsiella pneumoniae, Carbapenems, Methicillin Resistance |
| Popis: | Background Monitoring pathogens of bloodstream infections (BSI) and their antibiotic susceptibility is important to guide empiric antibiotic treatment strategies and prevention programs. This study assessed the epidemiology of BSI and antibiotic resistance patterns at the German Federal State of Thuringia longitudinally. Methods A surveillance network consisting of 26 hospitals was established to monitor BSIs from 01/2015 to 12/2019. All blood culture results, without restriction of age of patients, of the participating hospitals were reported by the respective microbiological laboratory. A single detection of obligate pathogens and a repeated detection of coagulase-negative staphylococci, Bacillus spp., Corynebacterium spp., Micrococcus spp. and Propionibacterium spp., within 96 h were regarded as a relevant positive blood culture. If one of the aforementioned non-obligate pathogens has been detected only once within 96 h, contamination has been assumed. Logistic regression models were applied to analyse the relationship between resistance, year of BSI and hospital size. Generalized estimating equations were used to address potential clustering. Results A total of 343,284 blood cultures (BC) of 82,527 patients were recorded. Overall, 2.8% (n = 9571) of all BCs were classified as contaminated. At least one relevant pathogen was identified in 13.2% (n = 45,346) of BCs. Escherichia coli (25.4%) was the most commonly detected pathogen, followed by Staphylococcus aureus (15.2%), Staphylococcus epidermidis (8.1%) and Klebsiella pneumoniae (4.6%). In S. aureus, we observed a decline of methicillin resistance (MRSA) from 10.4% in 2015 to 2.5% in 2019 (p Enterococcus faecium (VRE) has increased from 16.7% in 2015 to 26.9% in 2019 (p E. coli from 10.7% in 2015 to 14.5% in 2019 (p = 0.007) whereas 3GC resistance in K. pneumoniae was stable (2015: 9.9%; 2019: 7.4%, p = 0.35). Carbapenem resistance was less than 1% for both pathogens. These patterns were robustly observed across sensitivity analyses. Conclusions We observed evidence for a decline in MRSA, an increase in VRE and a very low rate of carbapenem resistance in gram-negative bacteria. 3GC resistance in E. coli increased constantly over time. |
| Druh dokumentu: | Article Conference object Other literature type |
| Jazyk: | English |
| ISSN: | 2047-2994 |
| DOI: | 10.1186/s13756-021-00997-6 |
| Přístupová URL adresa: | https://aricjournal.biomedcentral.com/track/pdf/10.1186/s13756-021-00997-6 https://pubmed.ncbi.nlm.nih.gov/34493334 https://doaj.org/article/253796cf50f44dd78a758e672ec33c19 https://link.springer.com/content/pdf/10.1186/s13756-021-00997-6.pdf https://pubmed.ncbi.nlm.nih.gov/34493334/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424790 https://aricjournal.biomedcentral.com/articles/10.1186/s13756-021-00997-6 https://repository.publisso.de/resource/frl:6464393 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....5bc11470ee4bb52b9d78f265c3b305d8 |
| Databáze: | OpenAIRE |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Background Monitoring pathogens of bloodstream infections (BSI) and their antibiotic susceptibility is important to guide empiric antibiotic treatment strategies and prevention programs. This study assessed the epidemiology of BSI and antibiotic resistance patterns at the German Federal State of Thuringia longitudinally. Methods A surveillance network consisting of 26 hospitals was established to monitor BSIs from 01/2015 to 12/2019. All blood culture results, without restriction of age of patients, of the participating hospitals were reported by the respective microbiological laboratory. A single detection of obligate pathogens and a repeated detection of coagulase-negative staphylococci, Bacillus spp., Corynebacterium spp., Micrococcus spp. and Propionibacterium spp., within 96 h were regarded as a relevant positive blood culture. If one of the aforementioned non-obligate pathogens has been detected only once within 96 h, contamination has been assumed. Logistic regression models were applied to analyse the relationship between resistance, year of BSI and hospital size. Generalized estimating equations were used to address potential clustering. Results A total of 343,284 blood cultures (BC) of 82,527 patients were recorded. Overall, 2.8% (n = 9571) of all BCs were classified as contaminated. At least one relevant pathogen was identified in 13.2% (n = 45,346) of BCs. Escherichia coli (25.4%) was the most commonly detected pathogen, followed by Staphylococcus aureus (15.2%), Staphylococcus epidermidis (8.1%) and Klebsiella pneumoniae (4.6%). In S. aureus, we observed a decline of methicillin resistance (MRSA) from 10.4% in 2015 to 2.5% in 2019 (p Enterococcus faecium (VRE) has increased from 16.7% in 2015 to 26.9% in 2019 (p E. coli from 10.7% in 2015 to 14.5% in 2019 (p = 0.007) whereas 3GC resistance in K. pneumoniae was stable (2015: 9.9%; 2019: 7.4%, p = 0.35). Carbapenem resistance was less than 1% for both pathogens. These patterns were robustly observed across sensitivity analyses. Conclusions We observed evidence for a decline in MRSA, an increase in VRE and a very low rate of carbapenem resistance in gram-negative bacteria. 3GC resistance in E. coli increased constantly over time. |
|---|---|
| ISSN: | 20472994 |
| DOI: | 10.1186/s13756-021-00997-6 |