Clinical and pathological characteristics of peripheral T‐cell lymphomas in a Spanish population: a retrospective study
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| Název: | Clinical and pathological characteristics of peripheral T‐cell lymphomas in a Spanish population: a retrospective study |
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| Autoři: | Socorro Maria Rodriguez‐Pinilla, Eva Domingo‐Domenech, Fina Climent, Joaquin Sanchez, Carlos Perez Seoane, Javier Lopez Jimenez, Monica Garcia‐Cosio, Dolores Caballero, Oscar Javier Blanco Muñez, Cecilia Carpio, Josep Castellvi, Antonio Martinez Pozo, Blanca Gonzalez Farre, Angeles Bendaña, Carlos Aliste, Ana Julia Gonzalez, Sonia Gonzalez de Villambrosia, Miguel A. Piris, Jose Gomez Codina, Empar Mayordomo‐Aranda, Belen Navarro, Carmen Bellas, Guillermo Rodriguez, Juan Jose Borrero, Ana Ruiz‐Zorrilla, Marta Grande, Carmen Montoto, Raul Cordoba |
| Přispěvatelé: | UAM. Departamento de Anatomía Patológica, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Takeda, Takeda Pharmaceutical Company, Institut Català de la Salut, [Rodriguez-Pinilla SM] Pathology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, CIBERONC, Madrid, Spain. [Domingo-Domenech E] Hematology Department, Institut Català d'Oncologia L'Hospitalet de Llobregat (Barcelona), Barcelona, Spain. [Climent F] Pathology Department, Hospital Universitari de Bellvitge. IDIBELL, L'Hospitalet de Llobregat (Barcelona), Barcelona, Spain. [Sanchez J, Perez Seoane C] Hematology Department and Pathology Department, Hospital Universitario Reina Sofía, Cordoba, Spain. [Lopez Jimenez J] Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Carpio C, Castellvi J] Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Servei de Patologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) |
| Zdroj: | Br J Haematol BRITISH JOURNAL OF HAEMATOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe Instituto de Investigación Sanitaria La Fe (IIS La Fe) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Biblos-e Archivo. Repositorio Institucional de la UAM instname RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía Digital.CSIC. Repositorio Institucional del CSIC Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Dipòsit Digital de la UB Universidad de Barcelona Consejo Superior de Investigaciones Científicas (CSIC) Biblos-e Archivo: Repositorio Institucional de la UAM Universidad Autónoma de Madrid |
| Informace o vydavateli: | Wiley, 2020. |
| Rok vydání: | 2020 |
| Témata: | Male, Limfomes, DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, T-Cell::Lymphoma, T-Cell, Peripheral, Anaplastic lymphoma kinase, 0302 clinical medicine, Otros calificadores::Otros calificadores::/diagnóstico, PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Prognosis, Overall survival, anaplastic large-cell lymphoma, peripheral T-cell lymphoma, Aged, 80 and over, Pronóstico, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células T::linfoma de células T periféricas, Progression-free survival, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::análisis de supervivencia, Haematological Malignancy ‐ Clinical, Complete response, anaplastic lymphoma kinase, Middle Aged, Prognosis, 3. Good health, Cèl·lules T, Lymphomas, Pacientes, Female, Adult, Adolescent, Medicina, overall survival, T cells, Ki-1 Antigen, Clasificación, Quinasa de Linfoma Anaplásico, Other subheadings::Other subheadings::/diagnosis, complete response, SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::pronóstico, Young Adult, 03 medical and health sciences, Anàlisi de supervivència (Biometria), Anaplastic large-cell lymphoma, Sobrevida, Humans, Aged, Retrospective Studies, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis, Carcinoma, Peripheral T-cell lymphoma, Lymphoma, T-Cell, Peripheral, Survival Analysis, Hodgkin, Malaltia de - Prognosi, anaplastic large-cell lymphoma, anaplastic lymphoma kinase, complete response, overall survival, peripheral T-cell lymphoma, progression-free survival, Spain, Virosis, Linfoma Anaplásico de Células Grandes, progression-free survival |
| Popis: | We investigated the clinicopathological features and prognostic factors of patients with peripheral T‐cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune‐related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy‐treated carcinomas 19%). The median progression‐free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P P P 15% of cells were positive in anaplastic lymphoma kinase‐positive and ‐negative anaplastic large‐cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re‐evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub‐classification, and response level to first‐line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Jazyk: | English |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.16741 |
| DOI: | 10.13039/100008373 |
| Přístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.16741 https://pubmed.ncbi.nlm.nih.gov/32426847 https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13288 https://hdl.handle.net/20.500.12530/58264 http://hdl.handle.net/10486/693948 http://hdl.handle.net/10668/15594 http://hdl.handle.net/10261/265101 https://hdl.handle.net/11351/7679 https://hdl.handle.net/2445/174243 http://hdl.handle.net/2445/174243 http://diposit.ub.edu/dspace/handle/2445/174243 https://pubmed.ncbi.nlm.nih.gov/32426847/ https://onlinelibrary.wiley.com/doi/10.1111/bjh.16741 https://europepmc.org/article/PMC/PMC7818499 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818499 https://www.ncbi.nlm.nih.gov/pubmed/32426847 https://hdl.handle.net/10486/693948 https://doi.org/10.1111/bjh.16741 https://hdl.handle.net/10668/15594 |
| Rights: | CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....5b0ee5d4df1db1c08677e8e93184f52c |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | We investigated the clinicopathological features and prognostic factors of patients with peripheral T‐cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune‐related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy‐treated carcinomas 19%). The median progression‐free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P P P 15% of cells were positive in anaplastic lymphoma kinase‐positive and ‐negative anaplastic large‐cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re‐evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub‐classification, and response level to first‐line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors. |
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| ISSN: | 13652141 00071048 |
| DOI: | 10.1111/bjh.16741 |