Antidiabetic Activity of Mung Bean Extracts in Diabetic KK-Ay Mice
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| Titel: | Antidiabetic Activity of Mung Bean Extracts in Diabetic KK-Ay Mice |
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| Autoren: | Wang, M, Wang, J, Ren, G, Yao, Y, Chen, F |
| Quelle: | Journal of Agricultural and Food Chemistry. 56:8869-8873 |
| Verlagsinformationen: | American Chemical Society (ACS), 2008. |
| Publikationsjahr: | 2008 |
| Schlagwörter: | Blood Glucose, Male, 0301 basic medicine, Inbred C57bl, Islets of Langerhans, Mice, 03 medical and health sciences, Plant Extracts - Therapeutic Use, Diabetes Mellitus - Blood - Drug Therapy, Diabetes Mellitus, Animals, Hypoglycemic Agents, Insulin, Islets Of Langerhans - Chemistry, Seeds - Chemistry, 0303 health sciences, Plant Extracts, Hypoglycemic Agents - Analysis, Fabaceae, Glucose Tolerance Test, Immunohistochemistry, Mice, Inbred C57bl, Mice, Inbred C57BL, Blood Glucose - Analysis, Insulin - Analysis, Seeds, Fabaceae - Chemistry, Phytotherapy |
| Beschreibung: | The antidiabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-A (y) mice and C57BL/6 mice were used in this study. In KK-A (y) mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice ( P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-A (y) mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-A (y) mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly improved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf8009238 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/18767859 https://pubag.nal.usda.gov/catalog/740407 https://www.ncbi.nlm.nih.gov/pubmed/18767859 https://pubs.acs.org/doi/abs/10.1021/jf8009238 http://hub.hku.hk/handle/10722/179092 https://pubmed.ncbi.nlm.nih.gov/18767859/ http://hdl.handle.net/10722/179092 |
| Dokumentencode: | edsair.doi.dedup.....59b1e138ffd82be68616638a4c459ddc |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | The antidiabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-A (y) mice and C57BL/6 mice were used in this study. In KK-A (y) mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice ( P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-A (y) mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-A (y) mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly improved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice. |
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| ISSN: | 15205118 00218561 |
| DOI: | 10.1021/jf8009238 |