Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission
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| Titel: | Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission |
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| Autoren: | Stockbauer, Anna, Beyer, Leonie, Huber, Maria, Kreuzer, Annika, Palleis, Carla, Katzdobler, Sabrina, Rauchmann, Boris-Stephan, Morbelli, Silvia, Chincarini, Andrea, Bruffaerts, Rose, Vandenberghe, Rik, Kramberger, Milica G., Trost, Maja, Garibotto, Valentina, Nicastro, Nicolas, Lathuiliere, Aurelien, Lemstra, Afina W., van Berckel, Bart N.M., Pilotto, Andrea, Padovani, Alessandro, Ochoa-Figueroa, Miguel A., Davidsson, Anette, Camacho, Valle, Peira, Enrico, Bauckneht, Matteo, Pardini, Matteo, Sambuceti, Gianmario, Aarsland, Dag, Nobili, Flavio, Gross, Mattes, Voeglein, Jonathan, Perneczky, Robert, Pogarell, Oliver, Buerger, Katharina, Franzmeier, Nicolai, Danek, Adrian, Levin, Johannes, Hoeglinger, Guenter U., Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Brendel, Matthias |
| Weitere Verfasser: | Universitat Autònoma de Barcelona, Levin, Johannes/0000-0001-5092-4306, Stockbauer, Anna, Beyer, Leonie, Huber , Maria, Kreuzer, Annika, Palleis, Carla, Katzdobler, Sabrina, Rauchmann, Boris-Stephan, Morbelli, Silvia, Chincarini, Andrea, BRUFFAERTS, Rose, Vandenberghe, Rik, Kramberger, Milica G., Trost, Maja, Garibotto, Valentina, Nicastro, Nicolas, Lathuiliere, Aurelien, Lemstra, Afina W., van Berckel, Bart N. M., Pilotto, Andrea, Padovani, Alessandro, Ochoa-Figueroa, Miguel A., Davidsson, Anette, Camacho, Valle, Peira, Enrico, Bauckneht, Matteo, Pardini, Matteo, Sambuceti, Gianmario, Aarsland, Dag, Nobili, Flavio, Gross, Mattes, Voeglein, Jonathan, Perneczky, Robert, Pogarell, Oliver, Buerger, Katharina, Franzmeier, Nicolai, Danek, Adrian, Levin, Johannes, Hoeglinger, Guenter U., Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Brendel, Matthias |
| Quelle: | Eur J Nucl Med Mol Imaging Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Stockbauer, A, Beyer, L, Huber, M, Kreuzer, A, Palleis, C, Katzdobler, S, Rauchmann, B-S, Morbelli, S, Chincarini, A, Bruffaerts, R, Vandenberghe, R, Kramberger, M G, Trost, M, Garibotto, V, Nicastro, N, Lathuilière, A, Lemstra, A W, van Berckel, B N M, Pilotto, A, Padovani, A, Ochoa-Figueroa, M A, Davidsson, A, Camacho, V, Peira, E, Bauckneht, M, Pardini, M, Sambuceti, G, Aarsland, D, Nobili, F, Gross, M, Vöglein, J, Perneczky, R, Pogarell, O, Buerger, K, Franzmeier, N, Danek, A, Levin, J, Höglinger, G N U, Bartenstein, P, Cumming, P, Rominger, A & Brendel, M 2023, 'Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission', European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-023-06493-w European journal of nuclear medicine and molecular imaging 51(4), 1023-1034 (2024). doi:10.1007/s00259-023-06493-w European journal of nuclear medicine and molecular imaging Stockbauer, Anna; Beyer, Leonie; Huber, Maria; Kreuzer, Annika; Palleis, Carla; Katzdobler, Sabrina; Rauchmann, Boris-Stephan; Morbelli, Silvia; Chincarini, Andrea; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Lathuilière, Aurélien; Lemstra, Afina W; van Berckel, Bart N M; Pilotto, Andrea; Padovani, Alessandro; ... (2024). Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. European journal of nuclear medicine and molecular imaging, 51(4), pp. 1023-1034. Springer 10.1007/s00259-023-06493-w <http://dx.doi.org/10.1007/s00259-023-06493-w> |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2023. |
| Publikationsjahr: | 2023 |
| Schlagwörter: | EXPRESSION, Lewy Body Disease, 616.8, DIAGNOSTIC-CRITERIA, 0299 Other Physical Sciences, Dopamine, Dementia with Lewy bodies, 610 Medicine & health, 618.97, Metabolic connectivity, Fluorodeoxyglucose F18, Alzheimer Disease, Humans, ddc:610, metabolism [Dopamine], FDG-PET, Biology, Science & Technology, 616.0757, diagnostic imaging [Lewy Body Disease], Radiology, Nuclear Medicine & Medical Imaging, Neurosciences, 1103 Clinical Sciences, DaT-Scan, 3. Good health, ALZHEIMERS-DISEASE, Nuclear Medicine & Medical Imaging, PET, metabolism [Glucose], Glucose, PRODROMAL DEMENTIA, 616.89, Positron-Emission Tomography, Original Article, Humans [MeSH], Lewy Body Disease/diagnostic imaging [MeSH], Fluorodeoxyglucose F18 [MeSH], Dopamine/metabolism [MeSH], Metabolic Networks and Pathways [MeSH], Positron-Emission Tomography [MeSH], Alzheimer Disease/metabolism [MeSH], Glucose/metabolism [MeSH], Human medicine, Life Sciences & Biomedicine, Neurovetenskaper, metabolism [Alzheimer Disease], Metabolic Networks and Pathways |
| Beschreibung: | Purpose Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease, multiple system atrophy) at individual patient level via principal component analysis (PCA). Methods FDG-PETs of subjects with probable or possible DLB (n = 22) without significant dopamine deficiency (z-score n = 23) and against DLB subjects with significant dopamine deficiency (n = 86). PCA was applied to test discrimination of patients with DLB from disease controls (n = 101) at individual patient level. Results Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (R2 = 0.597, p Conclusion Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-023-06493-w |
| DOI: | 10.48350/189129 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/37971501 https://research.vumc.nl/en/publications/d816c8f4-6fd1-4b58-80ce-02c42dffd2c0 https://pub.dzne.de/record/268317 https://pure.amsterdamumc.nl/en/publications/0ca7faf0-c686-499f-b16f-8d066ed4a724 https://doi.org/10.1007/s00259-023-06493-w https://archive-ouverte.unige.ch/unige:174082 https://doi.org/10.1007/s00259-023-06493-w https://hdl.handle.net/10067/2028590151162165141 https://repository.uantwerpen.be/docstore/d:irua:21845 https://boris.unibe.ch/189129/ https://repository.publisso.de/resource/frl:6524430 http://hdl.handle.net/1942/42290 http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200526 https://epub.ub.uni-muenchen.de/116446/ |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....593afe2d8aee17a3a29d0669c5bfe73c |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Purpose Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease, multiple system atrophy) at individual patient level via principal component analysis (PCA). Methods FDG-PETs of subjects with probable or possible DLB (n = 22) without significant dopamine deficiency (z-score n = 23) and against DLB subjects with significant dopamine deficiency (n = 86). PCA was applied to test discrimination of patients with DLB from disease controls (n = 101) at individual patient level. Results Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (R2 = 0.597, p Conclusion Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset. |
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| ISSN: | 16197089 16197070 |
| DOI: | 10.1007/s00259-023-06493-w |