The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition
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| Názov: | The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition |
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| Autori: | Rizzo, Alessio, Morbelli, Silvia, Albano, Domenico, Fornarini, Giuseppe, Cioffi, Martina, Laudicella, Riccardo, Dondi, Francesco, Grimaldi, Serena, Bertagna, Francesco, Racca, Manuela, Treglia, Giorgio, Bauckneht, Matteo |
| Zdroj: | Eur J Nucl Med Mol Imaging European journal of nuclear medicine and molecular imaging, vol. 51, no. 12, pp. 3753-3764 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Male, Glutamate Carboxypeptidase II, Humans, Glutamate Carboxypeptidase II/metabolism, Antigens, Surface/metabolism, Prostatic Neoplasms/diagnostic imaging, Prostatic Neoplasms/metabolism, Bone and Bones/diagnostic imaging, Bone and Bones/metabolism, Positron-Emission Tomography/methods, Biological Transport, Radioactive Tracers, Radiopharmaceuticals/pharmacokinetics, Bone metastastes, PET, Positron Emission Tomography, Prostate cancer, Prostate specific membrane Antigen, UBU, Prostatic Neoplasms, Review Article, Bone and Bones, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Positron-Emission Tomography, Antigens, Surface, Radiopharmaceuticals |
| Popis: | Purpose Prostate-Specific Membrane Antigen (PSMA)-targeted Positron Emission Tomography (PET) has revolutionised prostate cancer (PCa) diagnosis and treatment, offering superior diagnostic accuracy over traditional methods and enabling theragnostic applications. However, a significant diagnostic challenge has emerged with identifying unspecific bone uptakes (UBUs), which could lead to over-staging and inappropriate treatment decisions if misinterpreted. This systematic review explores the phenomenon of UBUs in PCa patients undergoing PSMA-PET imaging. Methods Studies assessing the prevalence, topographical distribution, and potential clinical implications of UBUs were selected according to the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) method and evaluated with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Results The percentage of PCa patients with UBUs on PSMA-PET scans ranged from 0 to 71.7%, depending on the radiopharmaceutical used, with [18F]PSMA-1007 showing the highest incidence. The ribs are the primary site of UBUs across all PSMA-targeted radiopharmaceuticals. The spine is the second most frequent UBU site for [68Ga]Ga-PSMA-11, [18F]DCFPyL, [18F]rhPSMA-7, while the pelvic girdle represents the second most frequent site for [18F]PSMA-1007. The average maximum Standardized Uptake Value (SUVmax) of UBUs varied from 3.4 to 7.7 and was generally lower than that of bone metastases. Conclusions Our findings underscore the need for heightened awareness and precise interpretation of UBUs to avoid potential over-staging and subsequent inappropriate treatment decisions. Considering the radiopharmaceutical used, PET-derived semiquantitative parameters, the topographical distribution of UBUs, and accurately evaluating the pre-test probability based on clinical and laboratory parameters may aid nuclear medicine physicians in interpreting PSMA-PET findings. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-024-06797-5 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38884773 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F504C36535AF4 https://serval.unil.ch/resource/serval:BIB_F504C36535AF.P001/REF.pdf https://serval.unil.ch/notice/serval:BIB_F504C36535AF https://hdl.handle.net/11570/3319216 https://doi.org/10.1007/s00259-024-06797-5 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....56b0eaaec6a0edf2a2ff187845924ab8 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Purpose Prostate-Specific Membrane Antigen (PSMA)-targeted Positron Emission Tomography (PET) has revolutionised prostate cancer (PCa) diagnosis and treatment, offering superior diagnostic accuracy over traditional methods and enabling theragnostic applications. However, a significant diagnostic challenge has emerged with identifying unspecific bone uptakes (UBUs), which could lead to over-staging and inappropriate treatment decisions if misinterpreted. This systematic review explores the phenomenon of UBUs in PCa patients undergoing PSMA-PET imaging. Methods Studies assessing the prevalence, topographical distribution, and potential clinical implications of UBUs were selected according to the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) method and evaluated with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Results The percentage of PCa patients with UBUs on PSMA-PET scans ranged from 0 to 71.7%, depending on the radiopharmaceutical used, with [18F]PSMA-1007 showing the highest incidence. The ribs are the primary site of UBUs across all PSMA-targeted radiopharmaceuticals. The spine is the second most frequent UBU site for [68Ga]Ga-PSMA-11, [18F]DCFPyL, [18F]rhPSMA-7, while the pelvic girdle represents the second most frequent site for [18F]PSMA-1007. The average maximum Standardized Uptake Value (SUVmax) of UBUs varied from 3.4 to 7.7 and was generally lower than that of bone metastases. Conclusions Our findings underscore the need for heightened awareness and precise interpretation of UBUs to avoid potential over-staging and subsequent inappropriate treatment decisions. Considering the radiopharmaceutical used, PET-derived semiquantitative parameters, the topographical distribution of UBUs, and accurately evaluating the pre-test probability based on clinical and laboratory parameters may aid nuclear medicine physicians in interpreting PSMA-PET findings. |
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| ISSN: | 16197089 16197070 |
| DOI: | 10.1007/s00259-024-06797-5 |