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Vitamin-mineral supplements and cognition among adults aged 65 and older: multiple cross-sectional population-based studies

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Title: Vitamin-mineral supplements and cognition among adults aged 65 and older: multiple cross-sectional population-based studies
Authors: Daniela Marques, Martin Preisig, Pedro Marques-Vidal
Source: Eur J Nutr
European journal of nutrition, vol. 64, no. 5, pp. 184
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Aged, 80 and over, Minerals, Humans, Female, Dietary Supplements, Aged, Cognition/drug effects, Cross-Sectional Studies, Vitamins/administration & dosage, Minerals/administration & dosage, Follow-Up Studies, Cohort Studies, Cognition, Cross-sectional study, Elderly people, Vitamin supplements, Original Contribution, Vitamins
Description: Purpose Many people consume vitamin-mineral supplements (VMS), to prevent cognitive decline or enhance cognition. We assessed the association between VMS intake and cognition. Methods Data from three follow-ups of the population-based CoLaus|PsyColaus cohort. Participants aged ≥ 65 years were included and categorized as VMS consumers or non-consumers. Cognitive tests included the Mini-Mental State Examination (MMSE), Stroop colour test, the CERAD praxis items, lexical and semantic fluency tasks, and the Grober and Buschke episodic memory test. Results There were 925 (64.5% women), 836 (41.1%), and 516 (29.4%) participants from the first (2009–2013), second (2014–2018) and third (2019–2021) follow-ups, respectively. After multivariable adjustment, no significant differences were found between VMS non-consumers and consumers regarding almost all cognitive tests. The multivariable-adjusted mean ± SEM of MMSE for VMS non-consumers vs. consumers were 29.27 ± 0.06 vs. 29.28 ± 0.09, 29.21 ± 0.06 vs. 29.28 ± 0.07 and 29.32 ± 0.08 vs. 29.21 ± 0.09 for the first, second, and third follow-ups, all p > 0.05. The exceptions were Stroop C, where non-consumers had a statistically better but clinically irrelevant performance than consumers at the third follow-up: effect size 0.30 (0.01; 0.58) p = 0.042 and the Grober and Buschke test in the first follow-up, where VMS consumers scored better than non-consumers in free recall: 9.11 ± 0.15 vs. 8.55 ± 0.10 (p = 0.003), with opposite findings in cued recall: 5.99 ± 0.14 vs. 6.48 ± 0.09 (p = 0.004). Conclusion We found no clinically significant association between VMS use and cognitive performance. Graphical Abstract
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1436-6215
1436-6207
DOI: 10.1007/s00394-025-03700-2
Access URL: https://pubmed.ncbi.nlm.nih.gov/40411557
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_76CFA0AA80B61
https://serval.unil.ch/notice/serval:BIB_76CFA0AA80B6
https://serval.unil.ch/resource/serval:BIB_76CFA0AA80B6.P001/REF.pdf
Rights: CC BY
Accession Number: edsair.doi.dedup.....568b566d6ac789a57c5532421f0ba40f
Database: OpenAIRE
Description
Abstract:Purpose Many people consume vitamin-mineral supplements (VMS), to prevent cognitive decline or enhance cognition. We assessed the association between VMS intake and cognition. Methods Data from three follow-ups of the population-based CoLaus|PsyColaus cohort. Participants aged ≥ 65 years were included and categorized as VMS consumers or non-consumers. Cognitive tests included the Mini-Mental State Examination (MMSE), Stroop colour test, the CERAD praxis items, lexical and semantic fluency tasks, and the Grober and Buschke episodic memory test. Results There were 925 (64.5% women), 836 (41.1%), and 516 (29.4%) participants from the first (2009–2013), second (2014–2018) and third (2019–2021) follow-ups, respectively. After multivariable adjustment, no significant differences were found between VMS non-consumers and consumers regarding almost all cognitive tests. The multivariable-adjusted mean ± SEM of MMSE for VMS non-consumers vs. consumers were 29.27 ± 0.06 vs. 29.28 ± 0.09, 29.21 ± 0.06 vs. 29.28 ± 0.07 and 29.32 ± 0.08 vs. 29.21 ± 0.09 for the first, second, and third follow-ups, all p > 0.05. The exceptions were Stroop C, where non-consumers had a statistically better but clinically irrelevant performance than consumers at the third follow-up: effect size 0.30 (0.01; 0.58) p = 0.042 and the Grober and Buschke test in the first follow-up, where VMS consumers scored better than non-consumers in free recall: 9.11 ± 0.15 vs. 8.55 ± 0.10 (p = 0.003), with opposite findings in cued recall: 5.99 ± 0.14 vs. 6.48 ± 0.09 (p = 0.004). Conclusion We found no clinically significant association between VMS use and cognitive performance. Graphical Abstract
ISSN:14366215
14366207
DOI:10.1007/s00394-025-03700-2