Zobrazit v EDS

Obesity increases the odds of intervertebral disc herniation and spinal stenosis; an MRI study of 1634 low back pain patients

Uloženo v:
Podrobná bibliografie
Název: Obesity increases the odds of intervertebral disc herniation and spinal stenosis; an MRI study of 1634 low back pain patients
Autoři: Anand H. Segar, Alice Baroncini, Jocelyn P. G. Urban, Jeremy Fairbank, Andrew Judge, Iain McCall
Zdroj: European Spine Journal. 33:915-923
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Lumbar Vertebrae, Lumbar Vertebrae/diagnostic imaging, Spinal Stenosis/complications, Intervertebral Disc Displacement/complications, Intervertebral Disc Degeneration/complications, Intervertebral Disc Degeneration, Middle Aged, Magnetic Resonance Imaging, Magnetic Resonance Imaging/methods, Spinal Stenosis, Intervertebral Disc/pathology, Child, Preschool, Humans, Low Back Pain/etiology, Obesity, Obesity/complications, Child, Preschool, Intervertebral Disc, Low Back Pain, Intervertebral Disc Displacement
Popis: The objective of this study was to examine the relationships between BMI and intervertebral disc degeneration (DD), disc herniation (DH) and spinal stenosis (SS) using a large, prospectively recruited and heterogeneous patient population.Patients were recruited through the European Genodisc Study. An experienced radiologist scored MRI images for DD, DH and SS. Multivariate linear and logistic regression analyses were used to model the relationship between these variables and BMI with adjustment for patient and MRI confounders.We analysed 1684 patients with a mean age of 51 years and BMI of 27.2 kg/m2. The mean DD score was 2.6 (out of 5) with greater DD severity with increasing age (R2 = 0.44). In the fully adjusted model, a 10-year increase in age and a 5 kg/m2 increase in BMI were associated, respectively, with a 0.31-unit [95% CI 0.29,0.34] and 0.04-unit [CI 0.01,0.07] increase in degeneration. Age (OR 1.23 [CI 1.06,1.43]) and BMI (OR 2.60 [CI 2.28,2.96]) were positively associated with SS. For DH, age was a negative predictor (OR 0.70 [CI 0.64,0.76]) but for BMI (OR 1.19 [CI 1.07,1.33]), the association was positive. BMI was the strongest predictor of all three features in the upper lumbar spine.While an increase in BMI was associated with only a slight increase in DD, it was a stronger predictor for DH and SS, particularly in the upper lumbar discs, suggesting weight loss could be a useful strategy for helping prevent disorders associated with these pathologies.
Druh dokumentu: Article
Jazyk: English
ISSN: 1432-0932
0940-6719
DOI: 10.1007/s00586-024-08154-4
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38363366
Rights: Springer Nature TDM
Přístupové číslo: edsair.doi.dedup.....567537fb99042883b7ac9b4bd9617b13
Databáze: OpenAIRE
Popis
Abstrakt:The objective of this study was to examine the relationships between BMI and intervertebral disc degeneration (DD), disc herniation (DH) and spinal stenosis (SS) using a large, prospectively recruited and heterogeneous patient population.Patients were recruited through the European Genodisc Study. An experienced radiologist scored MRI images for DD, DH and SS. Multivariate linear and logistic regression analyses were used to model the relationship between these variables and BMI with adjustment for patient and MRI confounders.We analysed 1684 patients with a mean age of 51 years and BMI of 27.2 kg/m2. The mean DD score was 2.6 (out of 5) with greater DD severity with increasing age (R2 = 0.44). In the fully adjusted model, a 10-year increase in age and a 5 kg/m2 increase in BMI were associated, respectively, with a 0.31-unit [95% CI 0.29,0.34] and 0.04-unit [CI 0.01,0.07] increase in degeneration. Age (OR 1.23 [CI 1.06,1.43]) and BMI (OR 2.60 [CI 2.28,2.96]) were positively associated with SS. For DH, age was a negative predictor (OR 0.70 [CI 0.64,0.76]) but for BMI (OR 1.19 [CI 1.07,1.33]), the association was positive. BMI was the strongest predictor of all three features in the upper lumbar spine.While an increase in BMI was associated with only a slight increase in DD, it was a stronger predictor for DH and SS, particularly in the upper lumbar discs, suggesting weight loss could be a useful strategy for helping prevent disorders associated with these pathologies.
ISSN:14320932
09406719
DOI:10.1007/s00586-024-08154-4