Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database
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| Titel: | Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database |
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| Autoren: | Davies, Elin Mitford, Buckley, Benjamin J. R., Austin, Philip, Lip, Gregory Y. H., Oni, Louise, McDowell, Garry, Rao, Anirudh |
| Quelle: | BMC Nephrol BMC Nephrology, Vol 25, Iss 1, Pp 1-16 (2024) Davies, E M, Buckley, B J R, Austin, P, Lip, G Y H, Oni, L, McDowell, G & Rao, A 2024, 'Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database', BMC Nephrology, vol. 25, no. 1, 233. https://doi.org/10.1186/s12882-024-03667-y |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Male, Adult, Databases, Factual, Cardiovascular Diseases/blood, MACE, Cardiovascular, Cohort Studies, 03 medical and health sciences, Glomerulonephritis, 0302 clinical medicine, Predictive Value of Tests, Natriuretic Peptide, Brain, Humans, Glomerulonephritis/blood, Mortality, Retrospective Studies, Aged, Research, Incidence, Troponin I, Biomarker, Middle Aged, Prognosis, Diseases of the genitourinary system. Urology, Peptide Fragments, 3. Good health, Troponin I/blood, Cardiovascular Diseases, Female, RC870-923, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Biomarkers/blood, Biomarkers |
| Beschreibung: | Rationale & objective Glomerulonephritis (GN) is a leading cause of chronic kidney disease (CKD). Major adverse cardiovascular events (MACE) are prolific in CKD. The risk of MACE in GN cohorts is multifactorial. We investigated the prognostic significance of routine cardiac biomarkers, Troponin I and N-terminal pro-BNP (NT-proBNP) in predicting MACE within 5 years of GN diagnosis. Study Design Retrospective cohort study. Setting & participants Data were obtained from TriNetX, a global federated health research network of electronic health records (EHR). Exposure or predictor Biomarker thresholds: Troponin I: 18 ng/L, NT-proBNP: 400 pg/mL. Outcomes Primary outcome: Incidence of major adverse cardiovascular events (MACE). Secondary outcome: was the risk for each individual component of the composite outcome. Analytical Approach 1:1 propensity score matching using logistic regression. Cox proportional hazard models were used to assess the association of cardiac biomarkers with the primary and secondary outcomes, reported as Hazard Ratio (HR) and 95% confidence intervals (CI). Survival analysis was performed which estimates the probability of an outcome over a 5-year follow-up from the index event. Results Following PSM, 34,974 and 18,218 patients were analysed in the Troponin I and NTproBNP cohorts, respectively. In the Troponin I all cause GN cohort, 3,222 (9%) developed composite MACE outcome HR 1.79; (95% CI, 1.70, 1.88, p p Limitations The data are derived from EHR for administrative purposes; therefore, there is the potential for data errors or missing data. Conclusions In GN, routinely available cardiac biomarkers can predict incident MACE. The results suggest the clinical need for cardiovascular and mortality risk profiling in glomerular disease using a combination of clinical and laboratory variables. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/s12882-024-03667-y |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39039475 https://doaj.org/article/f3c3dcddc4b24ad09589815d8cf81b5e https://vbn.aau.dk/ws/files/738886430/Davies_et_al._2024_._Routine_cardiac_biomarkers_for_the_prediction_of_incident_major_adverse_cardiac_events_in_patients_with_glomerulonephritis_-_a_real-world_analysis_using_a_global_federated_database.pdf https://doi.org/10.1186/s12882-024-03667-y http://www.scopus.com/inward/record.url?scp=85199184215&partnerID=8YFLogxK https://vbn.aau.dk/da/publications/696a37e4-b863-4a98-b3ac-8694b5a8db0b |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Dokumentencode: | edsair.doi.dedup.....5671be4c6dc7a28090aba216f2c7926f |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Rationale & objective Glomerulonephritis (GN) is a leading cause of chronic kidney disease (CKD). Major adverse cardiovascular events (MACE) are prolific in CKD. The risk of MACE in GN cohorts is multifactorial. We investigated the prognostic significance of routine cardiac biomarkers, Troponin I and N-terminal pro-BNP (NT-proBNP) in predicting MACE within 5 years of GN diagnosis. Study Design Retrospective cohort study. Setting & participants Data were obtained from TriNetX, a global federated health research network of electronic health records (EHR). Exposure or predictor Biomarker thresholds: Troponin I: 18 ng/L, NT-proBNP: 400 pg/mL. Outcomes Primary outcome: Incidence of major adverse cardiovascular events (MACE). Secondary outcome: was the risk for each individual component of the composite outcome. Analytical Approach 1:1 propensity score matching using logistic regression. Cox proportional hazard models were used to assess the association of cardiac biomarkers with the primary and secondary outcomes, reported as Hazard Ratio (HR) and 95% confidence intervals (CI). Survival analysis was performed which estimates the probability of an outcome over a 5-year follow-up from the index event. Results Following PSM, 34,974 and 18,218 patients were analysed in the Troponin I and NTproBNP cohorts, respectively. In the Troponin I all cause GN cohort, 3,222 (9%) developed composite MACE outcome HR 1.79; (95% CI, 1.70, 1.88, p p Limitations The data are derived from EHR for administrative purposes; therefore, there is the potential for data errors or missing data. Conclusions In GN, routinely available cardiac biomarkers can predict incident MACE. The results suggest the clinical need for cardiovascular and mortality risk profiling in glomerular disease using a combination of clinical and laboratory variables. |
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| ISSN: | 14712369 |
| DOI: | 10.1186/s12882-024-03667-y |