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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus

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Title: Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus
Authors: Low, Chan Yew, Gan, Wei Ling, Lai, Su Jeat, Tam, Rachel Su-May, Tan, Jie Fei, Dietl, Stefanie, Chuah, Lay Hong, Voelcker, Nicolas, Bakhtiar, Athirah
Source: J Nanobiotechnology
Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-25 (2025)
Low, C Y, Gan, W L, Lai, S J, Tam, R S-M, Tan, J F, Dietl, S, Chuah, L H, Voelcker, N & Bakhtiar, A 2025, ' Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus ', Journal of Nanobiotechnology, vol. 23, no. 1, 16 . https://doi.org/10.1186/s12951-024-03062-7
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Oral, Blood Glucose, Diabetes Mellitus, Type 2/drug therapy, Oral insulin, Administration, Oral, Hypoglycemic Agents/therapeutic use, Review, Clinical, Blood Glucose/drug effects, Drug Delivery Systems, Type 2 diabetes mellitus, Diabetes Mellitus, Drug Delivery Systems/methods, Medical technology, Humans, Insulin, Hypoglycemic Agents, Animals, R855-855.5, Preclinical, Type 2/drug therapy, Diabetes Mellitus, Type 2, Administration, Insulin/administration & dosage, Advance drug delivery, TP248.13-248.65, Biotechnology
Description: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related complications. However, given the injectable nature of exogenous insulin, apprehensions regarding its safety and the difficulties associated with its administration have hindered its widespread and prompt utilization. In this context, advanced oral insulin formulations can improve medication adherence in patients with diabetes and enhance their quality of life. Over the last 20 years, sophisticated pharmaceutical technologies have been utilized to provide insulin through oral formulations. Despite the limited absorption of oral insulin, these studies have demonstrated encouraging outcomes in translating clinical discoveries into commercialization. This review examines the advancements of several oral insulin formulations in preclinical and clinical trials, their effectiveness and safety characteristics, and potential implications for future treatment options. Graphical Abstract
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1477-3155
DOI: 10.1186/s12951-024-03062-7
Access URL: https://pubmed.ncbi.nlm.nih.gov/39815320
https://doaj.org/article/ed2b8a6d82d54c719b59f5d89f53fc08
https://curis.ku.dk/ws/files/422452217/s12951_024_03062_7.pdf
Rights: CC BY
Accession Number: edsair.doi.dedup.....56204e4b1de2d13f4791870a60f37361
Database: OpenAIRE
Description
Abstract:Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related complications. However, given the injectable nature of exogenous insulin, apprehensions regarding its safety and the difficulties associated with its administration have hindered its widespread and prompt utilization. In this context, advanced oral insulin formulations can improve medication adherence in patients with diabetes and enhance their quality of life. Over the last 20 years, sophisticated pharmaceutical technologies have been utilized to provide insulin through oral formulations. Despite the limited absorption of oral insulin, these studies have demonstrated encouraging outcomes in translating clinical discoveries into commercialization. This review examines the advancements of several oral insulin formulations in preclinical and clinical trials, their effectiveness and safety characteristics, and potential implications for future treatment options. Graphical Abstract
ISSN:14773155
DOI:10.1186/s12951-024-03062-7