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Analysis of temporal survival trends: considerations and best practice: considerations and best practice

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Titel: Analysis of temporal survival trends: considerations and best practice: considerations and best practice
Autoren: Mikkel Runason Simonsen, Lars Klingen Gjærde, Lars Hernández Nielsen, Jan Brink Valentin, Rasmus Plenge Waagepetersen, Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen
Quelle: BMC Med Res Methodol
BMC Medical Research Methodology, Vol 25, Iss 1, Pp 1-11 (2025)
Simonsen, M R, Gjærde, L K, Nielsen, L H, Valentin, J B, Waagepetersen, R P, El-Galaly, T C & Jakobsen, L H 2025, 'Analysis of temporal survival trends: considerations and best practice', BMC Medical Research Methodology, vol. 25, no. 1, 51. https://doi.org/10.1186/s12874-025-02505-5
Verlagsinformationen: Springer Science and Business Media LLC, 2025.
Publikationsjahr: 2025
Schlagwörter: Medicine (General), Lymphoma, Large B-Cell, Diffuse/mortality, Lymphoma, Research, Denmark, Registries/statistics & numerical data, Diffuse large B-cell lymphoma, Survival Analysis, Denmark/epidemiology, Causality, R5-920, Diffuse/mortality, Healthcare monitoring, Large B-Cell, Mediation analysis, Humans, Lymphoma, Large B-Cell, Diffuse, Registries
Beschreibung: Monitoring quality of healthcare is vital to ensure that changes made to clinical practice achieve the intended goals. Assessing temporal trends due to the accumulated effect of all changes in clinical practice in a given period is essential in quality monitoring. However, this assesment is compplicated by the fact that numerous of changes might occour over time unrelated to the clinical practice. Furthermore, the methods used to assess temporal trends in patient outcomes in the medical literature are heterogeneous, making it difficult to compare results between studies. In this paper, we describe methods that enable researchers to investigate temporal trends in survival data and we discuss their pros and cons. Numerous unrelated changes may occur over time which must be taken into account and disentangled when assessing the improvement in clinical management. The methods and interpretation thereof are exemplified on patients with diffuse large B-cell lymphoma from the Danish lymphoma registry.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1471-2288
DOI: 10.1186/s12874-025-02505-5
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39987028
https://doaj.org/article/d1fec8bb46b346eeac2165277aa6b2d7
https://vbn.aau.dk/ws/files/773345240/Simonsen_et_al._2025_._Analysis_of_temporal_survival_trends_-_considerations_and_best_practice.pdf
https://vbn.aau.dk/da/publications/77443bab-b480-46b4-92f6-5a7444ebc058
https://doi.org/10.1186/s12874-025-02505-5
http://www.scopus.com/inward/record.url?scp=85218693409&partnerID=8YFLogxK
Rights: CC BY NC ND
Dokumentencode: edsair.doi.dedup.....52d67fe99368b8fe7e6039208f5d2495
Datenbank: OpenAIRE
Beschreibung
Abstract:Monitoring quality of healthcare is vital to ensure that changes made to clinical practice achieve the intended goals. Assessing temporal trends due to the accumulated effect of all changes in clinical practice in a given period is essential in quality monitoring. However, this assesment is compplicated by the fact that numerous of changes might occour over time unrelated to the clinical practice. Furthermore, the methods used to assess temporal trends in patient outcomes in the medical literature are heterogeneous, making it difficult to compare results between studies. In this paper, we describe methods that enable researchers to investigate temporal trends in survival data and we discuss their pros and cons. Numerous unrelated changes may occur over time which must be taken into account and disentangled when assessing the improvement in clinical management. The methods and interpretation thereof are exemplified on patients with diffuse large B-cell lymphoma from the Danish lymphoma registry.
ISSN:14712288
DOI:10.1186/s12874-025-02505-5