In EDS ansehen

Expression of estrogen-related receptors in ovarian cancer and impact on survival

Gespeichert in:
Bibliographische Detailangaben
Titel: Expression of estrogen-related receptors in ovarian cancer and impact on survival
Autoren: Schüler-Toprak, Susanne, Weber, Florian, Skrzypczak, Maciej, Ortmann, Olaf, Treeck, Oliver
Quelle: J Cancer Res Clin Oncol
Verlagsinformationen: Springer Science and Business Media LLC, 2021.
Publikationsjahr: 2021
Schlagwörter: Ovarian Neoplasms, ERRalpha Estrogen-Related Receptor, ddc:610, 610 Medizin, Prognosis, Adenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Endometrial Neoplasms, 3. Good health, Survival Rate, 03 medical and health sciences, 0302 clinical medicine, Receptors, Estrogen, Cystadenocarcinoma, Serous/pathology [MeSH], Ovarian Neoplasms/mortality [MeSH], Cystadenocarcinoma, Serous/metabolism [MeSH], Adenocarcinoma, Mucinous/mortality [MeSH], Endometrial Neoplasms/mortality [MeSH], Tissue microarray, Ovarian Neoplasms/metabolism [MeSH], Estrogen-related receptors, Adenocarcinoma, Clear Cell/metabolism [MeSH], Ovarian Neoplasms/pathology [MeSH], Adenocarcinoma, Mucinous/metabolism [MeSH], Female [MeSH], Endometrial Neoplasms/metabolism [MeSH], Follow-Up Studies [MeSH], Original Article – Cancer Research, Receptors, Estrogen/metabolism [MeSH], Ovarian cancer, Humans [MeSH], Overall survival, Retrospective Studies [MeSH], Cystadenocarcinoma, Serous/mortality [MeSH], Adenocarcinoma, Clear Cell/mortality [MeSH], Survival Rate [MeSH], Endometrial Neoplasms/pathology [MeSH], Adenocarcinoma, Clear Cell/pathology [MeSH], Biomarkers, Tumor/metabolism [MeSH], Adenocarcinoma, Mucinous/pathology [MeSH], Prognosis [MeSH], Progression-free survival, Estrogen-related receptors, Ovarian cancer, Overall survival, Progression-free survival, Tissue microarray, Biomarkers, Tumor, Humans, Female, Adenocarcinoma, Clear Cell, Follow-Up Studies, Retrospective Studies
Beschreibung: Purpose This study further approaches the role of estrogen-related receptors (ERRs) in ovarian cancer. Protein expression of ERRα, ERRβ and ERRγ in ovarian cancer was assessed and was correlated with ovarian cancer markers, steroid hormone receptors and cancer-associated genes. Additionally, we examined to what extent expression of ERRs affects survival of ovarian cancer patients. Methods For this purpose, we established a tissue microarray from 208 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins. Results ERRα and ERRγ protein could be detected at different levels in more than 90% of all ovarian cancer tissues, whereas expression of ERRβ was observed in 82.2% of the cases. ERRα was found to positively correlate with ovarian cancer marker CEA (p p p p Conclusion Our data demonstrating that ERR proteins are frequently expressed in ovarian cancer and high levels of ERRβ and ERRγ significantly decreased OS of serous ovarian cancer patients suggest that these proteins might be interesting therapy targets in this cancer entity.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-021-03673-9
DOI: 10.5283/epub.45989
DOI: 10.5283/epub.4598910.1007/s00432-021-03673-9
Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00432-021-03673-9.pdf
https://pubmed.ncbi.nlm.nih.gov/34089362
https://link.springer.com/content/pdf/10.1007/s00432-021-03673-9.pdf
https://www.ncbi.nlm.nih.gov/pubmed/34089362
https://epub.uni-regensburg.de/45989/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310835
https://link.springer.com/article/10.1007/s00432-021-03673-9
https://pubmed.ncbi.nlm.nih.gov/34089362/
https://link.springer.com/article/10.1007/s00432-021-03673-9
https://doi.org/10.1007/s00432-021-03673-9
https://repository.publisso.de/resource/frl:6449854
https://epub.uni-regensburg.de/45989/
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Dokumentencode: edsair.doi.dedup.....52b9ae61255a0bd711b288b846761ceb
Datenbank: OpenAIRE
Beschreibung
Abstract:Purpose This study further approaches the role of estrogen-related receptors (ERRs) in ovarian cancer. Protein expression of ERRα, ERRβ and ERRγ in ovarian cancer was assessed and was correlated with ovarian cancer markers, steroid hormone receptors and cancer-associated genes. Additionally, we examined to what extent expression of ERRs affects survival of ovarian cancer patients. Methods For this purpose, we established a tissue microarray from 208 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins. Results ERRα and ERRγ protein could be detected at different levels in more than 90% of all ovarian cancer tissues, whereas expression of ERRβ was observed in 82.2% of the cases. ERRα was found to positively correlate with ovarian cancer marker CEA (p p p p Conclusion Our data demonstrating that ERR proteins are frequently expressed in ovarian cancer and high levels of ERRβ and ERRγ significantly decreased OS of serous ovarian cancer patients suggest that these proteins might be interesting therapy targets in this cancer entity.
ISSN:14321335
01715216
DOI:10.1007/s00432-021-03673-9