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Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients

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Title: Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients
Authors: Yaqubi, Kaneschka, Kostev, Karel, Klein, Isabel, Schüssler, Sofia, May, Petra, Luedde, Tom, Roderburg, Christoph, Loosen, Sven H.
Source: Eur J Med Res
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-7 (2024)
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Crohn's disease, Male, 0301 basic medicine, Multiple Sclerosis, Research, Incidence, IBD, MS, Inflammatory Bowel Diseases, CD, 3. Good health, 03 medical and health sciences, UC, 0302 clinical medicine, Ulcerative colitis, Crohn Disease, Quality of Life, Medicine, Humans, Colitis, Ulcerative, Colitis, Ulcerative/diagnosis [MeSH], Inflammatory Bowel Diseases/epidemiology [MeSH], Colitis, Ulcerative/epidemiology [MeSH], Humans [MeSH], Neurodegenerative disease, Crohn Disease/complications [MeSH], Crohn Disease/diagnosis [MeSH], Crohn Disease/epidemiology [MeSH], Incidence [MeSH], Retrospective Studies [MeSH], Multiple Sclerosis/complications [MeSH], Male [MeSH], Quality of Life [MeSH], Multiple Sclerosis/epidemiology [MeSH], Colitis, Ulcerative/complications [MeSH], Inflammatory Bowel Diseases/complications [MeSH], Retrospective Studies
Description: Background Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have a significant impact on patients' quality of life. In the present manuscript, we investigate the association between IBD and MS in a German cohort of general practice patients. These results may have important implications for the screening and management of patients with IBD, as well as for further research into the pathophysiological mechanisms underlying both disorders. Methods 4,934 individuals with IBD (11,140 with Crohn’s disease (CD) and 13,794 with ulcerative colitis (UC)) as well as 24,934 propensity score matched individuals without IBD were identified from the Disease Analyzer database (IQVIA). A subsequent diagnosis of MS was analyzed as a function of IBD using Cox regression models. Results After 10 years of follow-up, 0.9% and 0.7% of CD and UC patients but only 0.5% and 0.3% of matched non-IBD pairs were diagnosed with MS, respectively (pCD = 0.002 and pUC Conclusion The results of our analysis suggest a notable association between IBD and a subsequent MS diagnosis. These findings warrant further pathophysiological investigation and may have clinical implications for the screening of IBD patients in the future.
Document Type: Article
Other literature type
File Description: Text
Language: English
ISSN: 2047-783X
DOI: 10.1186/s40001-024-01776-w
Access URL: https://pubmed.ncbi.nlm.nih.gov/38504334
https://doaj.org/article/40ddeff5a8e44339be69c1c14e54a6aa
https://repository.publisso.de/resource/frl:6491050
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Accession Number: edsair.doi.dedup.....4fe90edd1057cbefa847995b2d2c6a73
Database: OpenAIRE
Description
Abstract:Background Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have a significant impact on patients' quality of life. In the present manuscript, we investigate the association between IBD and MS in a German cohort of general practice patients. These results may have important implications for the screening and management of patients with IBD, as well as for further research into the pathophysiological mechanisms underlying both disorders. Methods 4,934 individuals with IBD (11,140 with Crohn’s disease (CD) and 13,794 with ulcerative colitis (UC)) as well as 24,934 propensity score matched individuals without IBD were identified from the Disease Analyzer database (IQVIA). A subsequent diagnosis of MS was analyzed as a function of IBD using Cox regression models. Results After 10 years of follow-up, 0.9% and 0.7% of CD and UC patients but only 0.5% and 0.3% of matched non-IBD pairs were diagnosed with MS, respectively (pCD = 0.002 and pUC Conclusion The results of our analysis suggest a notable association between IBD and a subsequent MS diagnosis. These findings warrant further pathophysiological investigation and may have clinical implications for the screening of IBD patients in the future.
ISSN:2047783X
DOI:10.1186/s40001-024-01776-w