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Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls

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Název: Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls
Autoři: Franziska van den Bongard, Julia Kristin Gowik, Jessica Coenen, Rasmus Jakobsmeyer, Claus Reinsberger
Zdroj: Exp Brain Res
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, Adult, Epilepsy, Sympathetic Nervous System, Brain, Electroencephalography, Galvanic Skin Response, Middle Aged, Young Adult, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Exercise Test, Humans, Exercise Test [MeSH], Female [MeSH], Adult [MeSH], Electroencephalography/methods [MeSH], Humans [MeSH], Middle Aged [MeSH], Seizure-free, Galvanic Skin Response/physiology [MeSH], Autonomic nervous system, Sympathetic Nervous System/physiopathology [MeSH], Exercise/physiology [MeSH], Brain/physiopathology [MeSH], Epilepsy/physiopathology [MeSH], Male [MeSH], Young Adult [MeSH], Heart Rate/physiology [MeSH], Research Article, Exhaustive exercise, Electrocardiography [MeSH], Functional connectivity, Female, Exercise
Popis: Ictal and interictal activity within the autonomic nervous system is characterized by a sympathetic overshoot in people with epilepsy. This autonomic dysfunction is assumed to be driven by alterations in the central autonomic network. In this study, exercise-induced changes of the interrelation of central and peripheral autonomic activity in patients with epilepsy was assessed. 21 patients with epilepsy (16 seizure-free), and 21 healthy matched controls performed an exhaustive bicycle ergometer test. Immediately before and after the exercise test, resting state electroencephalography measurements (Brain Products GmbH, 128-channel actiCHamp) of 5 min were carried out to investigate functional connectivity assessed by phase locking value in source space for whole brain, central autonomic network and visual network. Additionally, 1-lead ECG (Brain products GmbH) was performed to analyze parasympathetic (root mean square of successive differences (RMSSD) of the heart rate variability) and sympathetic activity (electrodermal activity (meanEDA)). MeanEDA increased (p p p = 0.004) after exercise. Both patients with epilepsy and normal control subjects revealed the expected physiological peripheral autonomic responses to acute exhaustive exercise, but alterations of the correlation between central autonomic and peripheral sympathetic activity may indicate a different sympathetic reactivity after exercise in patients with epilepsy. The clinical relevance of this finding and its modulators (seizures, anti-seizure medication, etc.) still needs to be elucidated.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-1106
0014-4819
DOI: 10.1007/s00221-024-06792-0
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38551692
https://repository.publisso.de/resource/frl:6523274
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....4fbfd0245e3b67a5dc6f550b7cb9fcf6
Databáze: OpenAIRE
Popis
Abstrakt:Ictal and interictal activity within the autonomic nervous system is characterized by a sympathetic overshoot in people with epilepsy. This autonomic dysfunction is assumed to be driven by alterations in the central autonomic network. In this study, exercise-induced changes of the interrelation of central and peripheral autonomic activity in patients with epilepsy was assessed. 21 patients with epilepsy (16 seizure-free), and 21 healthy matched controls performed an exhaustive bicycle ergometer test. Immediately before and after the exercise test, resting state electroencephalography measurements (Brain Products GmbH, 128-channel actiCHamp) of 5 min were carried out to investigate functional connectivity assessed by phase locking value in source space for whole brain, central autonomic network and visual network. Additionally, 1-lead ECG (Brain products GmbH) was performed to analyze parasympathetic (root mean square of successive differences (RMSSD) of the heart rate variability) and sympathetic activity (electrodermal activity (meanEDA)). MeanEDA increased (p p p = 0.004) after exercise. Both patients with epilepsy and normal control subjects revealed the expected physiological peripheral autonomic responses to acute exhaustive exercise, but alterations of the correlation between central autonomic and peripheral sympathetic activity may indicate a different sympathetic reactivity after exercise in patients with epilepsy. The clinical relevance of this finding and its modulators (seizures, anti-seizure medication, etc.) still needs to be elucidated.
ISSN:14321106
00144819
DOI:10.1007/s00221-024-06792-0