Circulation of hypervirulent carbapenem-resistant Klebsiella pneumoniae in humans and fish in Djibouti
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| Názov: | Circulation of hypervirulent carbapenem-resistant Klebsiella pneumoniae in humans and fish in Djibouti |
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| Autori: | Lokman Galal, Hasna Saïd Mohamed, Chloé Dupont, Guilhem Conquet, Christian Carriere, Mohamed Houmed Aboubaker, Sylvain Godreuil |
| Prispievatelia: | Du gène à l'écosystème (MIVEGEC-GeneSys), Pathogènes, Environnement, Santé Humaine (EPATH), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Général Peltier, Laboratoire de Diagnostic, Caisse Nationale de Sécurité Sociale (CNSS), Djibouti, Republic of Djibouti., Laboratoire de Biologie Médicale de la Mer Rouge (Djibouti) (LBM Mer Rouge), French National Research Institute for Sustainable Development, Centre Hospitalier Universitaire de Montpellier |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 79:2068-2071 |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2024. |
| Rok vydania: | 2024 |
| Predmety: | Carbapenem resistance, [SDV]Life Sciences [q-bio], MESH: Klebsiella pneumoniae* / drug effects, MESH: Carbapenem-Resistant Enterobacteriaceae* / genetics, MESH: Djibouti / epidemiology, Microbial Sensitivity Tests, MESH: Virulence, MESH: Fish Diseases / microbiology, MESH: Klebsiella pneumoniae* / genetics, MESH: Anti-Bacterial Agents* / pharmacology, MESH: Klebsiella pneumoniae* / isolation & purification, Fish Diseases, Humans, Animals, MESH: Animals, MESH: Carbapenems* / pharmacology, MESH: Fishes / microbiology, MESH: Microbial Sensitivity Tests, MESH: Humans, Virulence, MESH: Klebsiella Infections* / drug therapy, Fishes, MESH: Anti-Bacterial Agents* / therapeutic use, MESH: Carbapenem-Resistant Enterobacteriaceae* / isolation & purification, Klebsiella Infections, Anti-Bacterial Agents, 3. Good health, Klebsiella pneumoniae, Carbapenem-Resistant Enterobacteriaceae, MESH: Carbapenem-Resistant Enterobacteriaceae* / drug effects, Carbapenems, Djibouti, MESH: Klebsiella Infections* / microbiology |
| Popis: | International audience ; Carbapenem-resistant (CR) hypervirulent Klebsiella pneumoniae (hvKP) is associated with poor clinical outcome and high death rates. Besides resistance to last-resort antibiotics, CR enterobacteria often exhibit multidrug-resistance phenotypes that greatly reduce the therapeutic options. Moreover, hypervirulent bacteria are highly invasive and spread rapidly. Until the early 2010s, these two phenotypes were not concomitantly observed in the same bacterial cell. Since then, carbapenem resistance and hypervirulence genetic determinants have been co-detected in many K. pneumoniae lineages.4 CR-hvKP were first reported in China, then in the Middle East and Europe and recently in sub-Saharan Africa.Here, we performed a retrospective analysis of whole genome sequencing data of CR-K. pneumoniae (CR-KP) isolates from Djibouti city, Djibouti, East Africa. The objectives of the present studies were to: (i) identify hvKP isolates; (ii) assess how hypervirulence intersects with carbapenem resistance and (iii) evaluate the possibility of their dissemination in the environment. The CR-KP isolates and sequencing data were from a previous One Health-based study on carbapenemase-producing Gram-negative bacilli (CP-GNB) in human (nosocomial and community-acquired infections), livestock, wildlife (fish) and water samples. In this previous study, 32 CP-GNB isolates, including five CR-KP isolates, were identified among the 1650 samples collected. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkae144 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38775735 |
| Rights: | OUP Standard Publication Reuse |
| Prístupové číslo: | edsair.doi.dedup.....4e275bbd7d58bb8c3c33a6513be1e379 |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | International audience ; Carbapenem-resistant (CR) hypervirulent Klebsiella pneumoniae (hvKP) is associated with poor clinical outcome and high death rates. Besides resistance to last-resort antibiotics, CR enterobacteria often exhibit multidrug-resistance phenotypes that greatly reduce the therapeutic options. Moreover, hypervirulent bacteria are highly invasive and spread rapidly. Until the early 2010s, these two phenotypes were not concomitantly observed in the same bacterial cell. Since then, carbapenem resistance and hypervirulence genetic determinants have been co-detected in many K. pneumoniae lineages.4 CR-hvKP were first reported in China, then in the Middle East and Europe and recently in sub-Saharan Africa.Here, we performed a retrospective analysis of whole genome sequencing data of CR-K. pneumoniae (CR-KP) isolates from Djibouti city, Djibouti, East Africa. The objectives of the present studies were to: (i) identify hvKP isolates; (ii) assess how hypervirulence intersects with carbapenem resistance and (iii) evaluate the possibility of their dissemination in the environment. The CR-KP isolates and sequencing data were from a previous One Health-based study on carbapenemase-producing Gram-negative bacilli (CP-GNB) in human (nosocomial and community-acquired infections), livestock, wildlife (fish) and water samples. In this previous study, 32 CP-GNB isolates, including five CR-KP isolates, were identified among the 1650 samples collected. |
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| ISSN: | 14602091 03057453 |
| DOI: | 10.1093/jac/dkae144 |