Optic nerve integrity as a visuospatial cognitive predictor in Parkinson’s disease
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| Názov: | Optic nerve integrity as a visuospatial cognitive predictor in Parkinson’s disease |
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| Autori: | Jae Jung Lee, Na-Young Shin, Yoonju Lee, Seung-Koo Lee, Young H. Sohn, Phil Hyu Lee |
| Prispievatelia: | College of Medicine, Dept. of Neurology, Jae Jung Lee, Na-Young Shin, Yoonju Lee, Seung-Koo Lee, Young H. Sohn, Phil Hyu Lee, Sohn, Young Ho, Lee, Seung Koo, Lee, Yoon Ju, Lee, Phil Hyu |
| Zdroj: | Parkinsonism & Related Disorders. 31:41-45 |
| Informácie o vydavateľovi: | Elsevier BV, 2016. |
| Rok vydania: | 2016 |
| Predmety: | Male, Cognition Disorders/etiology, Optic nerve, Statistics as Topic, Neuropsychological Tests, Parkinson Disease/pathology, Imaging, 03 medical and health sciences, Cognition, Imaging, Three-Dimensional, Spatial Processing, 0302 clinical medicine, Parkinson Disease/complications, Optic Nerve/diagnostic imaging, Humans, Optic Nerve/pathology, Aged, Retrospective Studies, Diffusion tensor image, Optic Nerve, Parkinson Disease, Middle Aged, Spatial Processing/physiology, 3. Good health, Diffusion Tensor Imaging, Positron-Emission Tomography, Three-Dimensional, Parkinson's disease, Anisotropy, Female, Cognition Disorders, Follow-Up Studies, Tropanes |
| Popis: | To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans.We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), and 36 controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured on the mid-portion of the intraorbital optic nerve. Using a multivariate analysis of variance with repeated measures, longitudinal changes in cognitive subscores of a comprehensive neuropsychological test were evaluated in PD patients according to optic nerve integrity.The mean FA value in PD was significantly lower (0.552 ± 0.103, p |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2016.06.020 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/27394650 https://www.ncbi.nlm.nih.gov/pubmed/27394650 https://yonsei.pure.elsevier.com/en/publications/optic-nerve-integrity-as-a-visuospatial-cognitive-predictor-in-pa https://www.sciencedirect.com/science/article/pii/S1353802016302401 https://dspace.ewha.ac.kr/handle/2015.oak/231805 https://pubmed.ncbi.nlm.nih.gov/27394650/ https://ir.ymlib.yonsei.ac.kr/handle/22282913/152245 |
| Rights: | Elsevier TDM CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....4c9afdb0eff62e84812dc2f9cc99b831 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans.We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), and 36 controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured on the mid-portion of the intraorbital optic nerve. Using a multivariate analysis of variance with repeated measures, longitudinal changes in cognitive subscores of a comprehensive neuropsychological test were evaluated in PD patients according to optic nerve integrity.The mean FA value in PD was significantly lower (0.552 ± 0.103, p |
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| ISSN: | 13538020 |
| DOI: | 10.1016/j.parkreldis.2016.06.020 |