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Dose-response associations of the American Heart Association's new 'Life's essential 8' metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States

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Title: Dose-response associations of the American Heart Association's new 'Life's essential 8' metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States
Authors: López-Bueno, Rubén, Calatayud, Joaquín, Pozo Cruz, Jesús del, Yang, Lin, Pozo Cruz, Borja del
Contributors: Universidad de Sevilla. Departamento de Educación Física y Deporte, Universidad de Sevilla. HUM1055: Epidemiology of Physical Activity and Fitness Across Lifespan
Source: Zaguán. Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Publisher Information: Elsevier BV, 2024.
Publication Year: 2024
Subject Terms: Male, Adult, Time Factors, Epidemiology, Health Status, Risk Assessment, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Cause of Death, Humans, Healthy Lifestyle, Prospective Studies, Cardiovascular Diseases/mortality, Aged, Preventive medicine, Public health, American Heart Association, Middle Aged, Protective Factors, United States/epidemiology, Lifestyle, Nutrition Surveys, Prognosis, United States, 3. Good health, Risk factors, Cardiovascular Diseases, Heart Disease Risk Factors, Female, Risk Reduction Behavior
Description: Our aim was to examine the prospective dose-response associations of American Heart Association's (AHA) LIFE's Essential 8 (LE8) score and number of cardiovascular health (CVH) factors with high score with all-cause and cardiovascular disease (CVD) related mortality.We pooled 6 consecutive waves of the National Health and Nutrition Examination Survey (NHANES) comprising rounds between 2007 and 2008 and 2017-2018. We calculated hazard ratios (HRs) and conducted restricted cubic splines models to assess the dose-response association of LE8 score and CVH factors with all-cause and CVD mortality.Analyses included 23,531 adults aged 18 years and over (mean [SD] age, 43.6 [16.7] years; 11,979 [51%] female; 8960 [38.1%] non-Hispanic white individuals) with a median follow-up of 7.3 years (IQR 4.3-10.1), corresponding to 168,033 person-years. The dose-response analyses showed a significant inverse curvilinear trend for the association between LE8 score with all-cause and CVD mortality. The optimal risk reduction for all-cause mortality was found at 100 points of the LE8 Score (HR, 0.50; 95% CI, 0.27-0.93) compared to the reference (median LE8 score [62.5 points]). Moreover, the dose-response association between LE8 and CVD mortality also exhibited a significant inverse curvilinear association up to 90 points (HR, 0.41; 95% CI, 0.17-0.99). Optimal levels of LE8 score may be able to avert around 40% of the annual all-cause and CVD deaths among the US adult population.Best-case scenario of CVH may reduce around 40% of the all-cause and CVD annual mortality among adults in the United States.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 0033-0620
DOI: 10.1016/j.pcad.2024.06.001
Access URL: https://pubmed.ncbi.nlm.nih.gov/38925257
http://zaguan.unizar.es/record/145046
https://hdl.handle.net/11441/161257
https://portal.findresearcher.sdu.dk/da/publications/485cdda9-1469-4247-99f9-5e55f23de9ae
https://doi.org/10.1016/j.pcad.2024.06.001
https://idus.us.es/handle//11441/161257
Rights: Elsevier TDM
CC BY NC ND
Accession Number: edsair.doi.dedup.....4bb3269bbff08b8b3b79a6daeca85f72
Database: OpenAIRE
Description
Abstract:Our aim was to examine the prospective dose-response associations of American Heart Association's (AHA) LIFE's Essential 8 (LE8) score and number of cardiovascular health (CVH) factors with high score with all-cause and cardiovascular disease (CVD) related mortality.We pooled 6 consecutive waves of the National Health and Nutrition Examination Survey (NHANES) comprising rounds between 2007 and 2008 and 2017-2018. We calculated hazard ratios (HRs) and conducted restricted cubic splines models to assess the dose-response association of LE8 score and CVH factors with all-cause and CVD mortality.Analyses included 23,531 adults aged 18 years and over (mean [SD] age, 43.6 [16.7] years; 11,979 [51%] female; 8960 [38.1%] non-Hispanic white individuals) with a median follow-up of 7.3 years (IQR 4.3-10.1), corresponding to 168,033 person-years. The dose-response analyses showed a significant inverse curvilinear trend for the association between LE8 score with all-cause and CVD mortality. The optimal risk reduction for all-cause mortality was found at 100 points of the LE8 Score (HR, 0.50; 95% CI, 0.27-0.93) compared to the reference (median LE8 score [62.5 points]). Moreover, the dose-response association between LE8 and CVD mortality also exhibited a significant inverse curvilinear association up to 90 points (HR, 0.41; 95% CI, 0.17-0.99). Optimal levels of LE8 score may be able to avert around 40% of the annual all-cause and CVD deaths among the US adult population.Best-case scenario of CVH may reduce around 40% of the all-cause and CVD annual mortality among adults in the United States.
ISSN:00330620
DOI:10.1016/j.pcad.2024.06.001