Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial
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| Titel: | Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial |
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| Autoren: | Okutani, Hiroai, Lo Vecchio, Silvia, Ammitzbøll, Nadia, Drewes, Asbjørn Mohr, Arendt-Nielsen, Lars |
| Quelle: | Okutani, H, Lo Vecchio, S, Ammitzbøll, N, Drewes, A M & Arendt-Nielsen, L 2023, 'Effects of oral morphine on experimentally evoked itch and pain : a randomized, double-blind, placebo-controlled trial', Scandinavian Journal of Pain, vol. 23, no. 4, pp. 743-750. https://doi.org/10.1515/sjpain-2023-0034 |
| Verlagsinformationen: | Walter de Gruyter GmbH, 2023. |
| Publikationsjahr: | 2023 |
| Schlagwörter: | Morphine, Analgesics, Opioid/adverse effects, opioid-induced itch, Pruritus, Pain, analgesia, experimentally evoked itch, Histamine/adverse effects, histamine, Analgesics, Opioid, Pain/drug therapy, Neurogenic Inflammation/complications, Pruritus/chemically induced, Humans, Morphine/adverse effects, pain, cowhage, Neurogenic Inflammation, Histamine |
| Beschreibung: | Objectives Pain and itch share similar neuronal networks; hence, it is difficult to explain why opioids can relieve pain but provoke itching. The present human volunteer study aimed to investigate the similarities and differences in responses to experimentally provoked pain and itching to explore the underlying fundamental mechanisms. Methods Twenty-four healthy volunteers were enrolled in this single-center, randomized, double-blind, placebo-controlled, parallel-group trial. Three volar forearms and two mandibular areas were marked, and participants randomly received morphine (20 mg) or identical placebo tablets. Heat, cold, and pressure pain thresholds, and vasomotor responses were assessed at baseline and after oral morphine administration. Itch provocations were induced by intradermal application of 1 % histamine or a topical cowhage (non-histaminergic itch) to a marked area of the skin. The participants were subsequently asked to rate their itching and pain intensities. The assessments were repeated for all marked areas. Results Morphine caused analgesia, as assessed by the significant modulation of cold and pressure pain thresholds (p Conclusions Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation. |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1877-8879 1877-8860 |
| DOI: | 10.1515/sjpain-2023-0034 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/37709368 http://www.scopus.com/inward/record.url?scp=85174417987&partnerID=8YFLogxK https://vbn.aau.dk/da/publications/5a8389e2-def7-4120-9d09-1b7dceebd42c https://vbn.aau.dk/ws/files/559430231/10.1515_sjpain-2023-0034.pdf https://doi.org/10.1515/sjpain-2023-0034 |
| Dokumentencode: | edsair.doi.dedup.....4b86e4f93caad4bcc221b4d72308c250 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Objectives Pain and itch share similar neuronal networks; hence, it is difficult to explain why opioids can relieve pain but provoke itching. The present human volunteer study aimed to investigate the similarities and differences in responses to experimentally provoked pain and itching to explore the underlying fundamental mechanisms. Methods Twenty-four healthy volunteers were enrolled in this single-center, randomized, double-blind, placebo-controlled, parallel-group trial. Three volar forearms and two mandibular areas were marked, and participants randomly received morphine (20 mg) or identical placebo tablets. Heat, cold, and pressure pain thresholds, and vasomotor responses were assessed at baseline and after oral morphine administration. Itch provocations were induced by intradermal application of 1 % histamine or a topical cowhage (non-histaminergic itch) to a marked area of the skin. The participants were subsequently asked to rate their itching and pain intensities. The assessments were repeated for all marked areas. Results Morphine caused analgesia, as assessed by the significant modulation of cold and pressure pain thresholds (p Conclusions Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation. |
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| ISSN: | 18778879 18778860 |
| DOI: | 10.1515/sjpain-2023-0034 |