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Lasting effects of transcranial direct current stimulation on the inducibility of synaptic plasticity by paired-associative stimulation in humans

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Názov: Lasting effects of transcranial direct current stimulation on the inducibility of synaptic plasticity by paired-associative stimulation in humans
Autori: Vestring, Stefan, Wolf, Elias, Dinkelacker, Johanna, Frase, Sibylle, Hessling-Zeinen, Carolin, Insan, Shrabon, Kumlehn, Maral M., Feige, Bernd, Domschke, Katharina, Normann, Claus, Frase, Lukas
Zdroj: J Neuroeng Rehabil
Journal of NeuroEngineering and Rehabilitation, Vol 21, Iss 1, Pp 1-12 (2024)
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2024.
Rok vydania: 2024
Predmety: Female [MeSH], Transcranial magnetic stimulation, Adult [MeSH], Humans [MeSH], Neuronal Plasticity/physiology [MeSH], Evoked Potentials, Motor/physiology [MeSH], Transcranial Direct Current Stimulation/methods [MeSH], Anodal, Cathodal, Brain stimulation, Long-Term Potentiation/physiology [MeSH], Motor Cortex/physiology [MeSH], Male [MeSH], Research, Young Adult [MeSH], Transcranial Magnetic Stimulation/methods [MeSH], Long-term potentiation, Male, Adult, Neuronal Plasticity, Long-Term Potentiation, Motor Cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, Transcranial Direct Current Stimulation, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Young Adult, Humans, Female, RC321-571
Popis: Background Transcranial direct current stimulation (tDCS) is capable of eliciting changes in cortical neuroplasticity. Increasing duration or repetition of tDCS during the after-effects of a first stimulation has been hypothesized to enhance efficacy. Computational models suggest sequential stimulation patterns with changing polarities to further enhance effects. Lasting tDCS effects on neural plasticity are of great importance for clinical applications. Objective The study systematically examined the influence of different tDCS paradigms on long term potentiation (LTP)-like plasticity in humans, focusing on stimulation duration, repetition frequency and sequential combinations of changing polarities as the underlying characteristics. Methods Amplitude changes of motor evoked potentials (MEP) were measured in response to paired associative stimulation (PAS) 6 h after application of different tDCS protocols. In total, 36 healthy participants completed the study, randomised into three groups with different stimulation protocols (N = 12 each). Results tDCS was able to display lasting modulatory effects on the inducibility of LTP-like plasticity in the human motor cortex 6 h after stimulation. TDCS with the anode on primary motor cortex significantly increased MEP amplitudes following PAS induction. Further analyses highlighted single stimulation block duration to be of higher importance than repetitive protocols for efficacy of effects. Conclusions tDCS is capable of inducing lasting changes in the brain’s capability to interact with future stimuli. Especially, effects on the inducibility of LTP-like plasticity might only be detectable with specific tests such as PAS and might otherwise be overlooked. Refined tDCS protocols should focus on higher current and duration of single stimulations instead of implementing complex repetitive schedules.
Druh dokumentu: Article
Other literature type
Popis súboru: pdf
Jazyk: English
ISSN: 1743-0003
DOI: 10.1186/s12984-024-01459-x
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39289746
https://doaj.org/article/7dbdb7c9646e40fa8d70a63867b98eab
https://repository.publisso.de/resource/frl:6493250
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....49e7129af4670258a94972a2805e65cf
Databáza: OpenAIRE
Popis
Abstrakt:Background Transcranial direct current stimulation (tDCS) is capable of eliciting changes in cortical neuroplasticity. Increasing duration or repetition of tDCS during the after-effects of a first stimulation has been hypothesized to enhance efficacy. Computational models suggest sequential stimulation patterns with changing polarities to further enhance effects. Lasting tDCS effects on neural plasticity are of great importance for clinical applications. Objective The study systematically examined the influence of different tDCS paradigms on long term potentiation (LTP)-like plasticity in humans, focusing on stimulation duration, repetition frequency and sequential combinations of changing polarities as the underlying characteristics. Methods Amplitude changes of motor evoked potentials (MEP) were measured in response to paired associative stimulation (PAS) 6 h after application of different tDCS protocols. In total, 36 healthy participants completed the study, randomised into three groups with different stimulation protocols (N = 12 each). Results tDCS was able to display lasting modulatory effects on the inducibility of LTP-like plasticity in the human motor cortex 6 h after stimulation. TDCS with the anode on primary motor cortex significantly increased MEP amplitudes following PAS induction. Further analyses highlighted single stimulation block duration to be of higher importance than repetitive protocols for efficacy of effects. Conclusions tDCS is capable of inducing lasting changes in the brain’s capability to interact with future stimuli. Especially, effects on the inducibility of LTP-like plasticity might only be detectable with specific tests such as PAS and might otherwise be overlooked. Refined tDCS protocols should focus on higher current and duration of single stimulations instead of implementing complex repetitive schedules.
ISSN:17430003
DOI:10.1186/s12984-024-01459-x