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Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease

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Názov: Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease
Autori: David Steinbart, Siti N. Yaakub, Mirja Steinbrenner, Lynn S. Guldin, Martin Holtkamp, Simon S. Keller, Bernd Weber, Theodor Rüber, Rolf A. Heckemann, Maria Ilyas‐Feldmann, Alexander Hammers
Zdroj: Hum Brain Mapp
Informácie o vydavateľovi: Wiley, 2023.
Rok vydania: 2023
Predmety: Epilepsy, Alzheimer Disease/diagnostic imaging, Piriform Cortex, Hippocampus, Magnetic Resonance Imaging, Temporal Lobe/diagnostic imaging, Magnetic Resonance Imaging/methods, Atrophy/pathology, 3. Good health, Epilepsy, Temporal Lobe, Alzheimer Disease, Humans, Atrophy, Hippocampus/diagnostic imaging, Research Articles
Popis: The piriform cortex (PC) is located at the junction of the temporal and frontal lobes. It is involved physiologically in olfaction as well as memory and plays an important role in epilepsy. Its study at scale is held back by the absence of automatic segmentation methods on MRI. We devised a manual segmentation protocol for PC volumes, integrated those manually derived images into the Hammers Atlas Database (n = 30) and used an extensively validated method (multi‐atlas propagation with enhanced registration, MAPER) for automatic PC segmentation. We applied automated PC volumetry to patients with unilateral temporal lobe epilepsy with hippocampal sclerosis (TLE; n = 174 including n = 58 controls) and to the Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n = 151, of whom with mild cognitive impairment (MCI), n = 71; Alzheimer's disease (AD), n = 33; controls, n = 47). In controls, mean PC volume was 485 mm3 on the right and 461 mm3 on the left. Automatic and manual segmentations overlapped with a Jaccard coefficient (intersection/union) of ~0.5 and a mean absolute volume difference of ~22 mm3 in healthy controls, ~0.40/ ~28 mm3 in patients with TLE, and ~ 0.34/~29 mm3 in patients with AD. In patients with TLE, PC atrophy lateralised to the side of hippocampal sclerosis (p p
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1097-0193
1065-9471
DOI: 10.1002/hbm.26274
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37052063
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....48f662837f77cde9937c2adfde15eb8e
Databáza: OpenAIRE
Popis
Abstrakt:The piriform cortex (PC) is located at the junction of the temporal and frontal lobes. It is involved physiologically in olfaction as well as memory and plays an important role in epilepsy. Its study at scale is held back by the absence of automatic segmentation methods on MRI. We devised a manual segmentation protocol for PC volumes, integrated those manually derived images into the Hammers Atlas Database (n = 30) and used an extensively validated method (multi‐atlas propagation with enhanced registration, MAPER) for automatic PC segmentation. We applied automated PC volumetry to patients with unilateral temporal lobe epilepsy with hippocampal sclerosis (TLE; n = 174 including n = 58 controls) and to the Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n = 151, of whom with mild cognitive impairment (MCI), n = 71; Alzheimer's disease (AD), n = 33; controls, n = 47). In controls, mean PC volume was 485 mm3 on the right and 461 mm3 on the left. Automatic and manual segmentations overlapped with a Jaccard coefficient (intersection/union) of ~0.5 and a mean absolute volume difference of ~22 mm3 in healthy controls, ~0.40/ ~28 mm3 in patients with TLE, and ~ 0.34/~29 mm3 in patients with AD. In patients with TLE, PC atrophy lateralised to the side of hippocampal sclerosis (p p
ISSN:10970193
10659471
DOI:10.1002/hbm.26274