Urinary Cadmium and Incident Heart Failure: A Case–Cohort Analysis Among Never-Smokers in Denmark
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| Title: | Urinary Cadmium and Incident Heart Failure: A Case–Cohort Analysis Among Never-Smokers in Denmark |
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| Authors: | Sears, Clara G, Eliot, Melissa, Raaschou-Nielsen, Ole, Poulsen, Aslak Harbo, Harrington, James M, Howe, Chanelle J, James, Katherine A, Roswall, Nina, Overvad, Kim, Tjønneland, Anne, Meliker, Jaymie, Wellenius, Gregory A |
| Source: | Sears, C G, Eliot, M, Raaschou-Nielsen, O, Poulsen, A H, Harrington, J M, Howe, C J, James, K A, Roswall, N, Overvad, K, Tjønneland, A, Meliker, J & Wellenius, G A 2022, 'Urinary cadmium and incident heart failure : A case-cohort analysis among never-smokers in Denmark', Epidemiology, vol. 33, no. 2, pp. 185-192. https://doi.org/10.1097/EDE.0000000000001446 Sears, C G, Eliot, M, Raaschou-Nielsen, O, Poulsen, A H, Harrington, J M, James, K A, Roswall, N, Overvad, K, Tjønneland, A, Meliker, J & Wellenius, G A 2022, ' Urinary Cadmium and Incident Heart Failure A Case-Cohort Analysis Among Never-Smokers in Denmark ', Epidemiology, vol. 33, no. 2, pp. 185-192 . https://doi.org/10.1097/EDE.0000000000001446 |
| Publisher Information: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Male, Cadmium/analysis, SEX-DIFFERENCES, cadmium, Incident heart failure, Denmark, UNITED-STATES, Urine biomarker, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, EPIDEMIOLOGY, Humans, EXPOSURE, RISK, Heart Failure, GENDER-DIFFERENCES, Case–cohort study design, Smokers, MORTALITY, Environmental Exposure, Middle Aged, incident heart failure, Denmark/epidemiology, VASCULAR ENDOTHELIAL-CELLS, 3. Good health, case-cohort study design, ATHEROSCLEROSIS, urine biomarker, Female, HEALTH, Heart Failure/epidemiology, Environmental Exposure/analysis, Cadmium |
| Description: | Background: Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked. Methods: Between 1993 and 1997, 19,394 never-smoking participants (ages 50–64 years) enrolled and provided a urine sample. From this sample, we randomly selected a subcohort of 600 men and 600 women and identified 958 incident heart failure cases occurring between baseline and 2015. Using a case–cohort approach, we estimated adjusted hazard ratios (aHR) for heart failure in Cox proportional hazards models with age as the time scale. Results: Participants had relatively low concentrations of urinary cadmium, as expected for never smokers (median = 0.20; 25th, 75th = 0.13, 0.32 μg cadmium/g creatinine). In adjusted models, we found that higher urinary cadmium was associated with a higher rate of incident heart failure overall (aHR = 1.1 per interquartile range difference [95% CI = 1.0, 1.2). In sex-stratified analyses, the association seemed restricted to men (aHR = 1.5 [95% CI = 1.2, 1.9]). Conclusions: In this cohort of people who never smoked tobacco, environmental cadmium was positively associated with incident heart failure, especially among men. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1044-3983 |
| DOI: | 10.1097/ede.0000000000001446 |
| Access URL: | https://journals.lww.com/epidem/Abstract/9000/Urinary_cadmium_and_incident_heart_failure__A.98197.aspx https://pubmed.ncbi.nlm.nih.gov/34860726 https://vbn.aau.dk/da/publications/5af29982-0714-4855-99fd-15361d4e2a9c https://vbn.aau.dk/ws/files/461704256/Sears_et_al._2022_._Urinary_Cadmium_and_Incident_Heart_Failure_A_Case_Cohort_Analysis_Among_Never_Smokers_in_Denmark.pdf https://doi.org/10.1097/EDE.0000000000001446 http://www.scopus.com/inward/record.url?scp=85123969317&partnerID=8YFLogxK https://www.ncbi.nlm.nih.gov/pubmed/34860726 https://pure.au.dk/portal/en/publications/abc05a51-c582-45dd-bde2-c35f6d6d06dc https://curis.ku.dk/ws/files/359733590/nihms_1758604.pdf https://pure.au.dk/portal/en/publications/abc05a51-c582-45dd-bde2-c35f6d6d06dc https://doi.org/10.1097/EDE.0000000000001446 https://pure.au.dk/ws/files/332741259/Urinary_Cadmium_and_Incident_Heart_Failure_A.5.pdf |
| Rights: | CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....48844734e215b644f23de865b9e6cde6 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background: Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked. Methods: Between 1993 and 1997, 19,394 never-smoking participants (ages 50–64 years) enrolled and provided a urine sample. From this sample, we randomly selected a subcohort of 600 men and 600 women and identified 958 incident heart failure cases occurring between baseline and 2015. Using a case–cohort approach, we estimated adjusted hazard ratios (aHR) for heart failure in Cox proportional hazards models with age as the time scale. Results: Participants had relatively low concentrations of urinary cadmium, as expected for never smokers (median = 0.20; 25th, 75th = 0.13, 0.32 μg cadmium/g creatinine). In adjusted models, we found that higher urinary cadmium was associated with a higher rate of incident heart failure overall (aHR = 1.1 per interquartile range difference [95% CI = 1.0, 1.2). In sex-stratified analyses, the association seemed restricted to men (aHR = 1.5 [95% CI = 1.2, 1.9]). Conclusions: In this cohort of people who never smoked tobacco, environmental cadmium was positively associated with incident heart failure, especially among men. |
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| ISSN: | 10443983 |
| DOI: | 10.1097/ede.0000000000001446 |