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Effect of a 6-Month Controlled Lifestyle Intervention on Common Carotid Intima-Media Thickness

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Název: Effect of a 6-Month Controlled Lifestyle Intervention on Common Carotid Intima-Media Thickness
Autoři: Koeder, Christian, Hahn, Andreas (Prof. Dr.), Englert, Heike (Prof. Dr.)
Zdroj: J Nutr Health Aging
Informace o vydavateli: Elsevier BV, 2021.
Rok vydání: 2021
Témata: Male, Carotid Artery, Common, Dewey Decimal Classification::600 | Technik::630 | Landwirtschaft, Veterinärmedizin, preventive medicine, Carotid Intima-Media Thickness, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, cardiovascular disease, Humans, Healthy Lifestyle, Life Style, Dewey Decimal Classification::600 | Technik::640 | Hauswirtschaft und Familienleben, Original Research, Aged, Ultrasonography, cardiovascular health, Middle Aged, 16. Peace & justice, Plant-based diet, 3. Good health, healthy aging, Female [MeSH], Aged [MeSH], Carotid Intima-Media Thickness [MeSH], Healthy Lifestyle [MeSH], Ultrasonography [MeSH], Humans [MeSH], Life Style [MeSH], Middle Aged [MeSH], Risk Factors [MeSH], Carotid Artery, Common/diagnostic imaging [MeSH], Cardiovascular Diseases/prevention, Male [MeSH], Cardiovascular Diseases/diagnostic imaging [MeSH], Cardiovascular Diseases, Female, Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
Popis: Objectives: The intima-media thickness of the common carotid artery (ccIMT) is an established risk marker for cardiovascular disease (CVD). However, it is unclear whether lifestyle interventions can easily demonstrate an improvement in ccIMT. The objective was to test if our intervention would beneficially affect ccIMT (among other CVD markers). Design: Non-randomized controlled trial Setting: Rural northwest Germany Participants: Middle-aged and elderly participants from the general population (intervention: n = 114; control: n = 87) Intervention: A community-based, 6-month controlled lifestyle intervention focusing on four areas of lifestyle change: a plant-based diet, physical activity, stress management, and an improved social life. A strong emphasis was on dietary change. Measurements: We tested whether ccIMT change from baseline to 6 months was different between groups. Results: With all participants included, no significant difference in mean ccIMT change between groups was observed (p = 0.708). However, in a subgroup analysis with participants with high baseline mean ccIMT (≥0.800 mm) a significant difference in mean ccIMT change between intervention (−0.023 [95% CI −0.052, 0.007] mm; n = 22; baseline mean ccIMT: 0.884 ± 0.015 mm) and control (0.041 [95% CI 0.009, 0.073] mm; n = 13; baseline mean ccIMT: 0.881 ± 0.022 mm) was observed (p = 0.004). Adjusting for potential confounders did not substantially alter the results. Conclusion: The results indicate that healthy lifestyle changes can beneficially affect ccIMT within 6 months and that such a beneficial effect may be more easily demonstrated if participants with high baseline ccIMT are recruited. The observed effect is of relevance for the prevention of CVD events, including myocardial infarction and stroke.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1279-7707
DOI: 10.1007/s12603-021-1628-0
DOI: 10.15488/15149
Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s12603-021-1628-0.pdf
https://pubmed.ncbi.nlm.nih.gov/34409964
https://pubmed.ncbi.nlm.nih.gov/34409964/
https://link.springer.com/content/pdf/10.1007/s12603-021-1628-0.pdf
https://link.springer.com/article/10.1007/s12603-021-1628-0
https://repository.publisso.de/resource/frl:6444216
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....48209ac525c88618c63a2c7cd8f576c9
Databáze: OpenAIRE
Popis
Abstrakt:Objectives: The intima-media thickness of the common carotid artery (ccIMT) is an established risk marker for cardiovascular disease (CVD). However, it is unclear whether lifestyle interventions can easily demonstrate an improvement in ccIMT. The objective was to test if our intervention would beneficially affect ccIMT (among other CVD markers). Design: Non-randomized controlled trial Setting: Rural northwest Germany Participants: Middle-aged and elderly participants from the general population (intervention: n = 114; control: n = 87) Intervention: A community-based, 6-month controlled lifestyle intervention focusing on four areas of lifestyle change: a plant-based diet, physical activity, stress management, and an improved social life. A strong emphasis was on dietary change. Measurements: We tested whether ccIMT change from baseline to 6 months was different between groups. Results: With all participants included, no significant difference in mean ccIMT change between groups was observed (p = 0.708). However, in a subgroup analysis with participants with high baseline mean ccIMT (≥0.800 mm) a significant difference in mean ccIMT change between intervention (−0.023 [95% CI −0.052, 0.007] mm; n = 22; baseline mean ccIMT: 0.884 ± 0.015 mm) and control (0.041 [95% CI 0.009, 0.073] mm; n = 13; baseline mean ccIMT: 0.881 ± 0.022 mm) was observed (p = 0.004). Adjusting for potential confounders did not substantially alter the results. Conclusion: The results indicate that healthy lifestyle changes can beneficially affect ccIMT within 6 months and that such a beneficial effect may be more easily demonstrated if participants with high baseline ccIMT are recruited. The observed effect is of relevance for the prevention of CVD events, including myocardial infarction and stroke.
ISSN:12797707
DOI:10.1007/s12603-021-1628-0