PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities
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| Název: | PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities |
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| Autoři: | Natalia Gorbokon, Sarah Baltruschat, Maximilian Lennartz, Andreas M. Luebke, Doris Höflmayer, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Christoph Fraune, Patrick Lebok, Christian Bernreuther, Guido Sauter, Andreas H. Marx, Ronald Simon, Till Krech, Till S. Clauditz, Frank Jacobsen, Eike Burandt, Stefan Steurer, Sarah Minner |
| Zdroj: | Virchows Arch |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2024. |
| Rok vydání: | 2024 |
| Témata: | 0301 basic medicine, PAX8 Transcription Factor, 03 medical and health sciences, 0302 clinical medicine, Female [MeSH], Immunohistochemistry, Cancer, Humans [MeSH], Diagnostic marker, Neoplasms/diagnosis [MeSH], Tissue Array Analysis [MeSH], Tissue microarray, Neoplasms/metabolism [MeSH], Immunohistochemistry [MeSH], Original Article, Neoplasms/pathology [MeSH], PAX8, Cadherins/analysis [MeSH], Biomarkers, Tumor/analysis [MeSH], PAX8 Transcription Factor/analysis [MeSH], Cadherins/metabolism [MeSH], Tissue Array Analysis, Neoplasms, Biomarkers, Tumor, Humans, Female, Cadherins |
| Popis: | PAX8 plays a role in development of the thyroid, kidney, and the Wolffian and Mullerian tract. In surgical pathology, PAX8 immunohistochemistry is used to determine tumors of renal and ovarian origin, but data on its expression in other tumors are conflicting. To evaluate PAX8 expression in normal and tumor tissues, a tissue microarray containing 17,386 samples from 149 different tumor types and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. PAX8 results were compared with previously collected data on cadherin 16 (CDH16). PAX8 positivity was found in 40 different tumor types. The highest rate of PAX8 positivity was found in thyroidal neoplasms of follicular origin (98.6–100%), gynecological carcinomas (up to 100%), renal tumors (82.6–97.8%), and urothelial neoplasms (2.3–23.7%). Important tumors with near complete absence of PAX8 staining (p |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-024-03872-y |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39105782 https://repository.publisso.de/resource/frl:6518168 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....4734641e7145a9dfd072c93765845134 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | PAX8 plays a role in development of the thyroid, kidney, and the Wolffian and Mullerian tract. In surgical pathology, PAX8 immunohistochemistry is used to determine tumors of renal and ovarian origin, but data on its expression in other tumors are conflicting. To evaluate PAX8 expression in normal and tumor tissues, a tissue microarray containing 17,386 samples from 149 different tumor types and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. PAX8 results were compared with previously collected data on cadherin 16 (CDH16). PAX8 positivity was found in 40 different tumor types. The highest rate of PAX8 positivity was found in thyroidal neoplasms of follicular origin (98.6–100%), gynecological carcinomas (up to 100%), renal tumors (82.6–97.8%), and urothelial neoplasms (2.3–23.7%). Important tumors with near complete absence of PAX8 staining (p |
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| ISSN: | 14322307 09456317 |
| DOI: | 10.1007/s00428-024-03872-y |